Karuna Ganesh karunamdphd - Bluesky Statics

Very excited to have been awarded a Cancer Grand Challenge grant as part of team REWIRE-CAN @cancergrand.bsky.social to develop new approaches to combat cancer #plasticity.
Our goal: to see all #colorectalcancer patients become colorectal cancer survivors.

04.03.2026 15:14 — 👍 36 🔁 2 💬 3 📌 0

Inferring cancer type-specific patterns of metastatic spread using Metient - Nature Methods Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data.

www.nature.com/articles/s41...

29.01.2026 17:45 — 👍 28 🔁 13 💬 3 📌 1

Super proud of all our amazing postdocs and the brilliant ideas and energy you contribute!

19.09.2025 14:43 — 👍 7 🔁 0 💬 0 📌 0

Congratulations Ellie @elliebenitez.bsky.social @mskeducation.bsky.social Tri-I MD/PhD student on being awarded the NIH/NCI F30 award! #proudPI

18.07.2025 18:43 — 👍 15 🔁 1 💬 1 📌 0

This is figure 2, which shows immigrant–native earnings differences after basic adjustments and within industry, occupation, establishment and job by world region of origin.

Immigrant workers, on average, are earning 17.9% less than a country’s native population, according to a paper in Nature. Three-quarters of the pay gap between the two correspond to a lack of accessible high-paying jobs for immigrants. go.nature.com/4nYgb0a #econsky 🧪

17.07.2025 13:41 — 👍 6 🔁 6 💬 0 📌 1

Thank you to all their mentors in the Ganesh lab, committees/programs and beyond for your concerted support and guidance in helping our trainees succeed 🙏

08.07.2025 07:48 — 👍 3 🔁 0 💬 0 📌 0

Congratulations Xiang (Molly), Masters student from @weillcornell.bsky.social - all the best for your PhD at Duke University Computational Bio!

08.07.2025 07:44 — 👍 0 🔁 0 💬 0 📌 0

Congratulations Emilie @emiliedevet.bsky.social, Masters student from @erasmusmc.bsky.social - all the best for your PhD at Harvard/MIT HST @harvard.edu @mit.edu!

08.07.2025 07:44 — 👍 0 🔁 0 💬 1 📌 0

Congratulations Aileen, Bridge Scholar @mskeducation.bsky.social - all the best for your PhD at Scripps/Oxford @scripps.edu @ox.ac.uk!

08.07.2025 07:44 — 👍 0 🔁 0 💬 1 📌 0

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), a gastrointestinal cancer that metastasizes almost exclusively to the peritoneum. Current treatments are extrapolated from colorectal cancer (CRC), yet AC has distinct genomic alterations, mucinous morphology and peritoneum restricted metastatic pattern. Further, no stable preclinical models of AC exist, limiting drug discovery and representing an unmet clinical need. We establish a first-in-class stable biobank of 16 long-term cultured AC patient-derived organoids (PDOs), including 3 matched, simultaneously resected primary AC-peritoneal carcinomatosis (AC-PC) pairs. By enriching for cancer cells, AC PDOs enable accurate genomic characterization relative to paucicellular AC tissue. We establish an organoid orthotopic intraperitoneal xenograft model that recapitulates diffuse peritoneal carcinomatosis and show that PC-organoids retain increased metastatic capacity, decreased growth factor dependency and sensitivity to standard of care chemotherapy relative to matched primary AC organoids. Single cell profiling of AC-PC pairs reveals dedifferentiation from mucinous differentiated states in primary AC into intestinal stem cell and fetal progenitor states in AC-PC, with upregulation of oncogenic signaling pathways. Through hypothesis-driven drug testing, we identify KRASMULTI-ON inhibitor RMC-7977 and Wnt-targeting tyrosine kinase inhibitor WNTinib as novel, clinically actionable strategies to target AC-PC more effectively. ### Competing Interest Statement K.G. is listed as an inventor on US patent 11,464,874, and US provisional patent applications 63/478,809 and 63/478,829 on targeting L1CAM to treat cancer, submitted by MSKCC. J.S. is a consultant for Paige AI.

Ahmed Mahmoud - our first PhD student, NSF GRFP and @hhmi.org Gilliam Fellow @weillcornell.bsky.social - thank you for trusting me to be your thesis advisor! A major milestone for the lab and check out his first preprint www.biorxiv.org/content/10.1...

08.07.2025 07:44 — 👍 0 🔁 0 💬 1 📌 0

Congratulations to our recent Ganesh lab alumni Ahmed Mahmoud, Emile de Vet @emiliedevet.bsky.social, Aileen Rodriguez, Xiang (Molly Han) @xianghan.bsky.social - we are so proud and wish you all the best for career success! @mskeducation.bsky.social @mskcancercenter.bsky.social

08.07.2025 07:44 — 👍 19 🔁 2 💬 2 📌 0

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social‬
www.nature.com/articles/s41...

04.06.2025 20:09 — 👍 20 🔁 2 💬 0 📌 0

Ready for an amazing educational session on tumor dormancy @theaacr.bsky.social with Drs. Isacke and Ganesh.

26.04.2025 16:50 — 👍 6 🔁 2 💬 0 📌 0

Congratulations Manisha Raghavan on winning both science and service awards at the Gerstner Sloan Kettering Graduate School retreat! #proudPI @mskeducation.bsky.social @mskcancercenter.bsky.social

11.04.2025 22:14 — 👍 20 🔁 2 💬 1 📌 0

Looking forward to sharing our work and learning about GI oncology research @mdanderson.bsky.social this week!

05.04.2025 21:15 — 👍 12 🔁 0 💬 0 📌 0

Congratulations Luke!

08.03.2025 19:11 — 👍 1 🔁 0 💬 0 📌 0

Thank you Mara! This work would not have been possible without bedrock NIH funding to MSKCC and to my lab through research and training grants, as well as the Dalton Family Foundation. This support enables us to work tirelessly to make progress against deadly cancers to benefit our patients.

24.02.2025 13:08 — 👍 3 🔁 0 💬 0 📌 0

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on a...

#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud

www.biorxiv.org/content/10.1...

24.02.2025 00:24 — 👍 36 🔁 3 💬 1 📌 1

Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD, comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy

14.02.2025 22:16 — 👍 23 🔁 1 💬 1 📌 1

📣The Beatson International Cancer Conference #BICC2025 is returning on Tuesday 27th – Thursday 29th May 2025 at the impressive Glasgow Science Centre!

Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science

www.beatsonconference.org

24.01.2025 13:37 — 👍 17 🔁 9 💬 1 📌 2

Thank you Trevor and Freddie for your thoughtful write up!

20.01.2025 18:47 — 👍 2 🔁 0 💬 0 📌 0

Thank you @trevorgraham.bsky.social and Freddie Whiting for this nice commentary on our recent paper on progressive plasticity in colorectal cancer metastasis

20.01.2025 18:18 — 👍 10 🔁 0 💬 0 📌 0

Starting 2025 with gratitude for @damonrunyon.org and all those who support our quest to understand and develop more effective treatments for metastatic cancer.

03.01.2025 04:41 — 👍 14 🔁 1 💬 0 📌 0

Progressive plasticity during colorectal cancer metastasis - Nature Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.

2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes.

@karunamdphd.bsky.social @mskcancercenter.bsky.social

www.nature.com/articles/s41...

23.12.2024 15:55 — 👍 16 🔁 1 💬 1 📌 0

Happy Nearly Holidays from the Ganesh lab!

18.12.2024 03:38 — 👍 19 🔁 0 💬 1 📌 0

Home - Cancer and Metabolism

Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...

05.12.2024 23:18 — 👍 45 🔁 13 💬 1 📌 0

Please add me

04.12.2024 23:10 — 👍 1 🔁 0 💬 0 📌 0

Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!

27.11.2024 21:55 — 👍 11 🔁 1 💬 0 📌 0

I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo

12.11.2024 11:49 — 👍 87 🔁 28 💬 38 📌 7

Non-canonical metastatic colorectal cancer - Nature Reviews Gastroenterology & Hepatology Nature Reviews Gastroenterology & Hepatology - Non-canonical metastatic colorectal cancer

First post on this platform - thank you Elena @natrevgastrohep.bsky.social for this nice highlight of our recent Nature paper 👇🏽

www.nature.com/articles/s41...

rdcu.be/d02rZ

21.11.2024 21:49 — 👍 64 🔁 5 💬 2 📌 0

Posts by Karuna Ganesh (@karunamdphd.bsky.social)