Dr James Kinross

The Guilty Little Pleasure Agonist Ultra processed weight loss, and why we can't have nice things

The real consequences of mass GLP1 agonist prescribing go for weight loss are not known, but this misuse is troubling. #ultraprocessedweightloss

open.substack.com/pub/drjamesk...
#weightliss #obesity #GLP1 #wegovy #semaglutide #weightlossjourney

I think it’s really cool! The question is how to scale this into a clinical biomarker.

The data on #protein supplements and health outcomes has some big holes. So my son isn’t allowed Creatine powder and he is furious about it. Here’s why. #forthegains

open.substack.com/pub/drjamesk...

Highly multiplexed spatial transcriptomics in bacteria Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈

“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo

Ultra-processed food? Forever chemicals? Declining birth rates? What’s behind rising cancer in the under-50s? Research into the disease has never been more far-reaching, but there is little consensus as to what is causing the rocketing rates of diagnosis in young adults

Why is #bowelcancer in the rise in the under 50s? Well…. It’s not forever chemicals. It’s not red meat. It’s not even UPFs. It’s the generational destruction of the microbiome caused by all of these things. It’s the #internalclimatecrisis obviously.

www.theguardian.com/science/2025...

This week our #XR #AI start up was featured in #NVIDIA CEO'Jensen Huang's #CES2025 key note. Huge congratulations to Philip Pratt and Kyriakos Lobotesis and whole Medical iSight team, and I can't wait to see this technology in clinical practice very soon.
#healthcare #artificialintelligence

Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals - Nature Microbiology Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.

🧵 How does being a #vegan, #vegetarian or omnivore impact your gut #microbiome? 🥦 Find out in our new paper on gut microbiome signatures of vegan, vegetarian & omnivore diets & associated health outcomes across 21,561 individuals in @naturemicrobiol.bsky.social!🎉 1/10

www.nature.com/articles/s41...

Posting it on Bluesky to save the post:
My grandfather built motors that powered big machines. In a lab not so different from his workshop, my colleagues and I uncovered the assembly of the bacterial motor. www.nature.com/articles/s41... @natureportfolio.bsky.social #MolecularNodes #Science #STEM

Ola! I have no idea what they are saying, but fingers crossed.

Portugal Welcomes First Wild Bison in 10,000 Years-the Keystone Species for Rewilding a Quarter-Million Acres Rewilding Europe is thrilled to announce the arrival of a small herd of bison in a large valley in Portugal. Believed to be the key to preventing catastrophic wildfires, invasive species spread, and promoting endemic biodiversity, it’s the first time...

Portugal Welcomes First Wild Bison in 10,000 Years-the Keystone Species for Rewilding a Quarter-Million Acres
->Good News Network | #Biodiversity #Rewilding #KeystoneSpecies | More info from EcoSearch

Dr Hussam Abu Safyia, I bear witness to your detention as if you were a Ukrainian doctor detained in Russian-occupied territory in violation of customary IHL. I wish my U.K. and German colleagues did likewise for there is no difference.

www.nytimes.com/2024/12/02/o...

James Kinross on Substack As I was making my post Christmas sandwiches with my favourite condiment, I wondered what it was doing to my microbiome. I think its doing something very very good, or very very bad… https://open.su...

substack.com/profile/5618...

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - Nature Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.

Rifaximin is handed out like smarties for a range of GI conditions like ‘SIBO’, because it acts locally in the gut and because it’s thought to not influence antibiotic resistance. Turns out… not so much:
#AMR #microbiome #GI #guthealth

www.nature.com/articles/s41...

Steven Bartlett sharing harmful health misinformation on Diary of CEO podcast Disproven health claims are accepted with little challenge by host on number one podcast, BBC investigation finds.

Diary of a serial evidenceless offender. Apparently it’s hard to find balance when discussing basic science (new), translational science (we should try this in patients) and evidence based medicine (it works / doesn’t work) and selling stuff.

https://buff.ly/4fgFe8M

Engaging cancer patients on their attitudes towards microbiome engineering technologies Microbiome engineering aims to develop engineered live biotherapeutic products to diagnose and treat human disease. One of the most active areas is in the engineering of modified bacteria that act as ...

Given the stark warnings on the creation of “mirror microbes” published in @science.org this week, we have asked our cancer patients about their attitudes towards synthetic engineering of microbes. Their response may surprise you.

www.biorxiv.org/content/10.1...

#microbiome #syntheticbiology