FEBS Letters

⚖️ Spinal muscular atrophy is caused by a survival motor neuron protein deficiency, with redox imbalance and oxidative stress also contributing. This study suggests:

📍 S-glutathionylation dysregulation as a #SMA hallmark
💊 Persistent #redox imbalance as a #therapeutic target

🔗 tinyurl.com/2vbsa7ka

🌍The transition of plants to land involved new signaling pathways helping them adapt to terrestrial life 🍃. This review highlights how #InositolPhosphates regulate #Growth, #StressResponses, and phosphate homeostasis, discussing their potential roles in #PlantEvolution. 🌱🪴

doi.org/10.1002/1873...

⌛This perspective on the mammalian circadian clock integrates genomic, structural, and single-molecule data showing that CLOCK:BMAL1 isn’t just a master switch—it shapes #Chromatin, teams with other TFs, and orchestrates enhancer dynamics to control circadian #GeneExpression

doi.org/10.1002/1873...

Today is the deadline for abstract submission for BioMalPar XXII: biology and pathology of the malaria parasite, taking place 27 - 29 May 2026 at EMBL! 🦟
Submit your abstract and register here ▶️ www.embl.org/about/info/c... #malaria @events.embl.org

🔔 Issue 4 of 2026 is live! Featuring:

🩸 Perspective: Aging of haematopoietic stem cells #HSCs
🔬 Review and original research on #genome organization
👨‍🔬 The Scientists' Forum: Effective collaboration in the Life Sciences
📡 Plus #enzymology, #biophysics, and plant biology 🌿

▶️ tinyurl.com/4hd2brwy

🎉🎖️Congratulations going out to ⭐Evaëlle Ferton ⭐ (Laval University, Québec, Canada), winner of the FEBS Letters #PosterPrize at the 18th Laval University #Neuroscience Research Day! 👏👏👏🎊

🎉🎖️We congratulate ⭐Marcell Harhai⭐ (University of Lausanne, Switzerland), on winning the FEBS Letters #PosterPrize at the #LifeSciences Switzerland (LS2) Annual Meeting, held in Zürich, Switzerland! 👏👏👏🎉

@marcellharhai.bsky.social @unil.bsky.social @lifesciswitzerland.bsky.social

#Phosphoinositides show dynamic patterns that shape membrane identity and signaling. This review covers their organization in well-studied and understudied organelles — ER and nucleus — and why spatial control matters for #CellBiology, #SignalTransduction and #Disease. 👨‍🔬🔬

doi.org/10.1002/1873...

There's still time to register to attend the Brain (epi)genome EMBO Workshop, to be held at EMBL Heidelberg 21 - 24 Apr 2026!! 🧠
Register to attend in person or virtually here:
www.embl.org/about/info/c...
#brain #genome #epigenome
@events.embl.org

@embo.org

HtrA’s chaperone and proteolytic activities are crucial for H. pylori survival and infection — making it a promising #DrugTarget. This review summarizes HtrA structure and function, its role in #infection and #pathogenesis, and the challenges of its therapeutic targeting 💊

doi.org/10.1002/1873...

Missed the registration deadline?
Good news-- you can still virtually attend the EMBO | EMBL Symposium "The cellular mechanics of symbiosis: sensing friend from foe"! 😊

Register online here! ▶️
www.embl.org/about/info/c...
#EESSymbiosis #symbiosis #hostmicrobe @events.embl.org @embo.org

Read it here: doi.org/10.1002/1873... 🔗

And find out more here: www.col4a1.net 🔗

#COL4A1 #COL4A2 #Collagen #Collagen4

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In our newest patient advocacy article FEBS Letters managing editor Duncan Wright speaks with Francesca Manodoro, Tom Van Agtmael, and Simona Balestrini about their experiences with Associazione Famiglie COL4A1-A2 and the field of COL4A1-A2 and rare disorder #research.

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Set up in 2021 by families of patients with COL4A1/A2 disorders, Associazione Famiglie COL4A1/A2 aims to support patients and their families, improve access to multidisciplinary management, and to work with #researchers and #clinicians to understand the mechanisms involved in these disorders.

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#COL4A1/A2 disorders are a group of rare #geneticdisorders caused by mutations in #collagen 4. Our latest #patientadvocacy article features an in-depth interview on the history of Associazione Famiglie COL4A1/A2 and developments in COL4A1/A2 research.

🧵

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Collaboration is the backbone of modern science – but seldom runs smoothly. In our latest The Scientists’ Forum article, Muhammad Naseem looks at the barriers to effective #collaborations as well as potential personal and institutional solutions. 🤝🔬🦠

#science #lifescience

doi.org/10.1002/1873...

🔗 See the full collection here: tinyurl.com/zfavccjz 🔬👩‍🔬

"Improving gender parity, and diversity more generally, is not only good for business, innovation, creativity and collaboration— it is good for society, the economy, and it is what is fair. Girls should be given equal opportunities to thrive" — Laura Norton

🔗 tinyurl.com/3xbebpf7

"Professor Langenheim dedicated over forty years of her career to studying plant exudates, especially the fossil resins we know as ambers. She approached her study from multiple disciplinary angles, for plant exudates had created a “cosmos” for her" — Rayane da Cruz Albino

🔗 tinyurl.com/2jcj4zmw

"We are getting better. We are out here, writing reviews and publishing, culturing cells, building models, and mentoring. The ‘other women’ are becoming scientists, tenured faculty, achievers—and some, I suspect, may be future Nobel laureates" — Mahaiwon Shadang

🔗 tinyurl.com/vpndy6dy

"We are eager to use the scaffolding more senior women have built for us and effect change to address the root causes of gender inequality in our fields. Strong role models and robust peer groups gave us the permission and confidence to demand better . . . " — Cara Giovanetti

🔗 tinyurl.com/3y3dmsxj

"By highlighting shared barriers and effective solutions, this work underscores the need for structural and cultural reforms to better support mothers in academia and retain talented scientists in STEM fields" — Devanshi Agarwal and Sonya E. Neal

🔗 tinyurl.com/bdcvr2m2

👩‍🔬Wishing everyone a happy International Day of Women and Girls in Science! #WomenInScience #EveryVoiceInScience

🔍Check out the collection linked below, which showcases articles reflecting on the issues and triumphs of women in their fields — plus some excerpts, featuring women in their own words.

The #GTPase #Npa3 plays a key role in RNA Pol II assembly & nuclear import. In a new study, Martín Mora-García et al. reveal crosstalk between Npa3 and #TORC1 signalling, suggesting involvement in translation initiation, TORC1 signaling, and #stress adaptation🧬

Read it here: tinyurl.com/bdau2mp2

☀️🌔How do mammalian cells align their internal clocks with the outside world? This review explores how light, feeding and temperature entrain cellular #CircadianRhythms, and why understanding the molecular mechanisms behind cellular timing matters for our #Health. doi.org/10.1002/1873...

🔔 Issue 3 of 2026 is live! Featuring:

🧫 Review: #Helicobacterpylori pathogenesis
🦠 In a Nutshell: Universal stress proteins in #mycobacteria
👨‍🔬: Highlights from the Susan Lindquist School on #Proteostasis
🔬 Research on #enzymology, structural #biology, and gene expression

▶️ tinyurl.com/3yxe4t9b

Skin wound healing depends on more than structure alone. 🩸This review explores how matricellular proteins fine-tune #ExtracellularMatrix signalling to coordinate cell migration, proliferation and tissue repair, highlighting their central role in #RegenerativeMedicine. doi.org/10.1002/1873...

The Dot/Icm type IV secretion system (#T4SS) is essential for #Legionella pneumophila infection, but the mechanism remains incompletely understood. In a new study, Dutka (@przemekdut.bsky.social) et al. provide insight into the molecular organization of T4SS. #Legionnaires🔎🔬
doi.org/10.1002/1873...

💊 Phosphatidylinositol 4-kinases are central regulators of cellular signaling and membrane trafficking, yet are frequently hijacked by pathogens. This review discusses their dual roles and evaluates their potential as #DrugTargets for #InfectiousDiseases. 🦠 doi.org/10.1002/1873...

What do extrachromosomal DNAs and excised signal circles have in common?⭕
This review highlights how both promote genome instability, pointing to potential #CancerVulnerabilities for #DrugDiscovery in #PrecisionOncology. doi.org/10.1002/1873...