FEBS Letters

#Amyotrophiclateralsclerosis (#ALS) can be caused by repeat expansions in C9orf72. A new study by David Vilchez et al. shows G3BP1 exhibits enhanced interaction with Nup107 in #motorneurons derived from patient iPSCs with C9orf72 mutations. @thevilchezlab.bsky.social
➡️https://tinyurl.com/zm2ujupc

🎉Congratulations to 🌟Selin Pekel🌟 (Leiden University Medical Center, the Netherlands), winner of the FEBS Letters #PosterPrize at the EMBO/EMBL Symposium ‘The human #microbiome’, held in Heidelberg, Germany! 🎉👏👏👏🎊

#EESMicrobiome

@events.embl.org
@selinpekel.bsky.social
@zellerlab.bsky.social

Congratulations! 🎉🌟

Mélanie Lemaire receives the Runner Up Poster Award

Gabriel Pérez-Lara receives the Best Poster Award

Awards were also given for poster presentations.

The Runner Up Poster Award, sponsored by
@natrevgenet.nature.com, went to Mélanie Lemaire (Université de Montréal, Canada), while the Best Talk Award, sponsored by @febsletters.bsky.social, went to Gabriel Pérez-Lara (UNAB, Chile).

🏅We congratulate 🌟Nils Bertram🌟 @lmumuenchen.bsky.social, on winning a FEBS Letters #PosterPrize at the #EMBOFEBSproteostasis meeting, held in Espoo, Finland! 🎉👏👏👏

📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright

From lactation to malignancy: a new study by Pietro Ancona et al. reveals new insights into #breastcancer through comparison of healthy and cancerous breast gland at single-cell resolution.
Read the full article here ➡️ tinyurl.com/bdcd4c7v

Gcn2 phosphorylates #eIF2α in response to amino acid starvation. In a new study published in FEBS Letters, Bianca J. M. Sansom et al. uncover how Yih1/IMPACT inhibits #Gcn2
Read online here➡️ tinyurl.com/ycymxch9
#proteinsynthesis

How does the multispecific #antibody G2 bind to different #peptides? 🤔 Nobutoshi Ito, Masayuki Oda, et al. answer this question in this new article in FEBS Letters➡️ tinyurl.com/jxzefyxd

The #chelatase activity of magnesium dechelatase is associated with #chlorophyll degradation.
Read the full article here ➡️ doi.org/p7td

🧬 Our most recent Editor's Choice article by Andrés D. Klein et al. report genomic modifiers of neurological resilience to #NiemannPick type C disease, a lysosomal storage disorder

➡️ doi.org/10.1002/1873-3468.70091

#Mitochondria #Biomarkers

#ERBIN is a key suppressor of #EMT through coordinated inhibition of TGF-β and EGFR signaling pathways.

Read the full article here ➡️ tinyurl.com/43z64k43

🔔 Issue 18 of FEBS Letters features articles on #photoreceptors, #immunology, and more, including:

👁️ Perspective: cGMP and cAMP systems in #RetinitisPigmentosa
🧬 In a Nutshell: #mRNA metabolism in immune cells
🫧 Editor's Choice: Genomic modifiers of #NiemannPick severity

➡️ bit.ly/4mIaSQE

🌟Elin Zätterman🌟(University of Dundee, Scotland) won a FEBS Letters #PosterPrize at the EMBO/FEBS Lecture Course 'Susan Lindquist School on #Proteostasis, held in Espoo, Finland!

🎉🏅Congratulations, Elin! 🎉👏👏👏

📸Photo: Elin with our Managing Editor, Dr. Duncan Wright.

#EMBOFEBSproteostasis

🎉🏅We congratulate 🌟Megan Lee 🌟 @eawag.bsky.social, winner of the FEBS Letters #PosterPrize at the EMBO/FEBS Lecture Course 'The New #Microbiology', recently held in Spetses, Greece! 🎉👏👏👏

#EMBOnewMicrobiology

Image depicting elements of graphical abstracts discussed in this article, presented as eight segments of a square: layout, colour, text, lines, the "sciency" touches, tools, AI, and proof-reading.

Looking to create an eye-catching #graphicalabstract to summarise your research? 🎨 Scientist and graphic designer Dr. Matteo Oliverio shares his tips and experience in this new guide published in @febsletters.bsky.social
Read the full article here ➡️ tiny.cc/1pqs001 #sciencecommunication

We're here for Day 3 of the Susan Lindquist School on Proteostasis! This has been a fantastic course, with talks on both the history of the field and the latest research, as well as many animated discussions--and there's much more yet! #ProteostasisSchool #Proteostasis #embofebsproteostasis

🎉🏅We congratulate 🌟Nils Reinhard 🌟 (University of Würzburg, Germany), winner of a FEBS Letters #PosterPrize at the European Biological Rhythms Society meeting #EBRS2025 in Lübeck, Germany! 🎉👏👏👏

@nils-reinhard.bsky.social

🎉🌟Ruoshi Li (University of Tsukuba, Japan) won a FEBS Letters #PosterPrize at the European Biological Rhythms Society meeting #EBRS2025 in Lübeck, Germany!

🏅Congratulations, Ruoshi! 🎉👏👏👏

#circadian

Very excited to be attending the fourth Susan Lindquist School on Proteostasis in Espoo, Finland! We enjoyed fantastic talks by Rick Morimoto, David Balchin, and Anne Bertolotti on the first day, and were happy to contribute to a discussion on academic publishing.
#embofebsproteostasis

Bacterial GES-1 is an extended-spectrum β-#lactamase conferring #AntimicrobialResistance.
Find out how it is inhibited by the β-lactamase inhibitors enmetazobactam and tazobactam

🖊️ Adrian Mulholland, James Spencer (University of Bristol) & colleagues

➡️ bit.ly/4n6AFmw

🎉🎖️We congratulate 🌟Julia Scott🌟(Center for Molecular Medicine, UMC Utrecht, the Netherlands), on winning the FEBS Letters #PosterPrize at the FEBS Advanced Lecture Course 'Functional #genomics of #metabolic diseases', held in Spetses, Greece! 🎉👏👏👏

@juliasscott.bsky.social

⏰ Nobel laureate Aziz Sancar reviews the molecular clock: how protein interactions & modifications drive circadian rhythms, with links to health & disease.
Read more: febs.onlinelibrary.wiley.com/doi/10.1002/...
#CircadianRhythms #MolecularBiology #clock

🔔 New Issue!

🩻 Articles on the #cytoskeleton and more, including:

🥇 Editor's Choice: β-#Actin mutation impairs SETD3-mediated methylation
🖊️ Review: Mechanisms of #GPCR anterograde transport
🧑‍🔬 Scientists' Forum: Building a new research group

➡️ bit.ly/47IrzHP

How do lipid-modified proteins reach the cilium? 🧬 ARL3 and its regulators create spatial control of cargo release—key to signaling & linked to ciliopathies like Joubert syndrome.
Read more: febs.onlinelibrary.wiley.com/doi/10.1002/...
#CellBiology #Cilia #GTPases

🔬 Why does cancer relapse years after treatment? Dormancy, aided by autophagy, helps tumors survive, hide & later reactivate.
Explore the autophagy–dormancy link: febs.onlinelibrary.wiley.com/doi/10.1002/...
#CancerResearch #Autophagy #Metastasis

🎉 We also congratulate two runners-up, whose essays will be published later this year:

Dr. Cara Giovanetti, "It Takes a Village: Preparing #WomenInScience for difficult times"

Mahaiwon Shadang, "The Other Women"

Thank you to every researcher who submitted!

@idontevencara.bsky.social

All aerobic life depends on pyruvate dehydrogenase complexes ⚡ Yet their structures and assembly vary widely across species. Discover the differences: febs.onlinelibrary.wiley.com/doi/10.1002/...
#Biochemistry #Metabolism #MolecularBiology

🥇👩‍🔬 Congratulations to Rayane da Cruz Albino winner of our 2025 Writing Contest: Celebrating #WomenInScience! 🎊

Her essay, “Black Pitch Illuminated: The legacy of Professor Jean H. Langenheim,” celebrates a trailblazer who inspired Albino’s own journey in ethnobotany.

➡️ bit.ly/3I21s3U

#WomenInSTEM

To survive multiple extreme conditions, polyextremophiles produce protective exopolysaccharides 🛡️Learn how these molecules aid adaptation: febs.onlinelibrary.wiley.com/doi/10.1002/...
#Microbiology #Extremophiles #Glycobiology

🔔 New Issue: Focus on #Autophagy and #Cancer, featuring three new Reviews:

🖊️ Transcriptional regulation of autophagy in cancer
🖊️ Autophagy in cancer, liver and brain disorders
🖊️ Autophagy and cancer dormancy

Plus Research articles on both iron #metabolism and #microbiology:

➡️ bit.ly/3VlJBYJ