Mikala Egeblad

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

COVID Infection May Ignite Dormant Cancer in Survivors, Study Says These patients should consider vaccination against respiratory viruses, according to researcher

www.medpagetoday.com/hematologyon...

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

Hidden in the lungs of some breast cancer survivors are tumor cells that can remain dormant for decades — until they one day trigger a relapse.

Now, experiments show for the first time these rogue cells can be roused from their slumber by common respiratory illnesses such as COVID-19 or the flu.

For early career researchers in our community - this is invaluable. Info here:
public.csr.nih.gov/ForReviewers...

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

@megeblad.bsky.social once more revealing significant cancer biology - Congrats!
www.nature.com/articles/s41...

A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.

Our latest review !

Great news! The AACR journals are now on BlueSky! Be sure to follow @aacrjournals.bsky.social!! #FollowFriday

I can confirm the PBS Passport is a very good deal for $5/month or $2.50/month if you do yearly.

Thousands of hours of top notch content. NOVA is great. The new Ken Burns doc on Leonardo da Vinci is excellent.

You can sign up at the link below!

www.pbs.org/passport/lea...

Check out some #CoolScienceImages (with music by Victor Leksell) from a @nature.com paper. In the study, @adrover.bsky.social, @megeblad.bsky.social, et al. found that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis: www.nature.com/articles/s41...
#FluorescenceFriday 🧪

I hear you 😉 We found a type of clot-causing neutrophils in cancer. By blocking tumor vessels, they drive tumor necrosis, which in turn cause metastasis. Key message: Necrosis can be an active process and necrosis can cause metastasis. Free link to article here: www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Exciting new work at @nature.com showing that Neutrophil Extracellular Traps in the vasculature can actively promote necrosis in cancer and that targeting NETs is can reduce necrosis and metastasis. Great work from @adrover.bsky.social @megeblad.bsky.social

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!

EACR-@themarkfdn.bsky.social Postdoctoral Fellowships are awarded for a period of three years and support excellent postdoctoral researchers in laboratories throughout Europe. Is that you?

Apply by 20 August: eacr.org/eacr-fellows...

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation - Nature Cell Biology Arya et al. report that migrating neutrophils resolve acute inflammation by releasing exosomes associated with nuclear DNA. This process is distinct from the release of neutrophil extracellular traps,...

#WeekendRead! #BeyondNETosis! @caroleparentlab.bsky.social @sbarya.bsky.social &co show @natcellbio.nature.com that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but at also favor inflammation resolution via neutrophil retrotransmigration!

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute Add brief description here

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

Rapid Response Bridge Funding Program In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

Very smart, high ROI initiative from the Spencer Foundation.

Providing bridge funding for canceled NSF grants:

1) directs funds to projects already screened by a top-noch review process.
2) avoids imposing proposal prep costs on researchers.
3) ameliorates the disruption from GOP sabotage.

I'm so excited for #ICDB2025, it's looking like such a great meeting and I'm honored to share our work!

Only a few days left before The CheckPoints: Rockin’ for a Cure! Join us on Sunday, June 1 at Buddy Guy’s Legends in Chicago. A suggested donation of $30 at the door will support the #SITCForwardFund. Learn more: www.sitcancer.org/about/the-ch...

Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...

Opening session of #AACR25 annual meeting - with all attendees raising signs in support of cancer research funding #CancerResearchSavesLives

Thanks to all at #AACR25 for an inspiring and impactful annual meeting!

Filled with cutting-edge science 🧪- and the direct impact of those discoveries for patients with #cancer

Special thanks to co-chairs @mvhlab.bsky.social @lilliansiu.bsky.social

#CancerResearchSavesLives

@theaacr.bsky.social

Spring 2009 I opened my lab and accepted two @cshlnews.bsky.social rotation students now reunited at #AACR25: University of Hawaii Cancer Center clinician-scientist Elizabeth Nakasone, and Mount Sinai assistant professor and @theaacr.bsky.social NextGen Star @elvinwag.bsky.social - Made my day!

We all know how much the microenvironment matters!

So grateful that the #TME field has so many fantastic - and supportive - women leaders 🙌

#AACR2025 🧪⚕️
#womeninscience
#payitforward

@theaacr.bsky.social