Oliver Stegle

Thank you. Looking forward, also to learn more about the HMC approach to metadata!

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Delighted to present Latent Interaction Variational Inference (LIVI), a framework for trans-eQTL mapping at single-cell resolution that I developed during my PhD together with colleagues from @steglelab.bsky.social 1/n

Interpretation, extrapolation and perturbation of single cells Nature Reviews Genetics - Causal and mechanistic modelling strategies, which aim to infer cause–effect relationships, provide insights into cellular responses to perturbations. The authors...

Fresh off the press in 2026! Interested in the challenge of how to advance from descriptive atlases to causal mechanisms and counterfactuals? 🔬
Take a look at our recent perspective: "Interpretation, extrapolation and perturbation of single cells"! (rdcu.be/eXeDY)

With @leopoldparts.bsky.social and @oliverstegle.bsky.social we comprehensively mapped CRISPRi responses in iPSCs identifying protein complexes as nexus for transcriptional changes and made a first step towards population-scale CRISPR screens to dissect genetic modulation of perturbation responses

I'm impressed by how far this model class has taken us—MOFA-FLEX may be the final iteration—a framework geared more towards generating models than being a standalone model itself. User-friendly, probabilistic programming rocks! We look forward to your feedback and experiences trying it out!

Group Leader – AI in Biology Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

If you want more information please contact @oliverstegle.bsky.social who is leading AI @ EMBL and please do forward this thread / websites to anyone who you think might be interested.

Technical Lead for the "Health + Life Science Alliance Data Space"

You are passionate about making data accessible? The Heidelberg Mannheim life science builds a data space - a major step for bridging basic science and translation. Two of more jobs to come. Technical lead and cloud engineer jobs.dkfz.de/en/jobs/1680... jobs.dkfz.de/en/jobs/1680...

Postdoctoral Researcher in Computational Genetics The research group of Oliver Stegle looks for a postdoctoral researcher to join a collaborative project with GSK with the goal to apply computational methods to investigate the effects of rare variant...

Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share!

embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...

Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?

ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.

Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik

#ChooseEurope

Super happy and proud of this one. We and others have developed tools for dimensionality reduction for many years. MOFA (linear) and other non-linear generalisations, space/time. scDORI fuses this with GRN inference. It’s a nice and useful piece of software. Here applied to GBM biology.

Happy birthday! What a trajectory in just 3y. More exciting tools & packages and of course community.

Multiple headlines about the first CRISPR 2.0 personalized genome editing and photo of the baby treated

This week's genome editing triumph is a big deal.
Here's why
erictopol.substack.com/p/the-first-...

The next #ScienceatDKFZ event will take place on Monday, 12 May 2025, at 4 pm. In addition to the keynote lecture by Christoph Plass, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...

Our unit is connecting @dkfz.bsky.social, @uniheidelberg.bsky.social & @embl.org -
@oliverstegle.bsky.social, @lena-maier-hein.bsky.social, @wkhuber.bsky.social, @brittavelten.bsky.social,
Anna Kreshuk, Carsten Rother, Fred Hamprecht, Jan Korbel, Ullrich Köthe, Klaus Maier-Hein, Tilman Plehn, ...

Head of an independent Junior Research Group with Tenure Option at the German Cancer Research Center (DKFZ)

Start your own group at DKFZ! jobs.dkfz.de/en/jobs/1677...

Trump Administration Has Begun a War on Science, Researchers Say (Gift Article) Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.

“We all rely on science.” U.S. scientists are speaking out for scientific integrity and academic freedom. What they’re doing matters. We owe them our solidarity and a clear stand beside them.
www.nytimes.com/2025/03/31/s...

Reverse brain drain? But yes, science in Europe is great!

Are you a young researcher and want to access state-of-the-art technology? The Corporate Partnership Programme is your chance! 💥

CPP cover:
💡 opportunity to build new networks
💰 short-term fellows up to 4.000€
🌍 eligible to stay at EMBL sites

Apply until 31 March: www.embl.org/about/info/s...

YouTube video by DW Deutsch Wie Europa von Trumps Krieg gegen die Wissenschaft profitieren könnte | DW Nachrichten

Interview von Wolfgang Wick mit der Deutschen Welle zum Thema "Brain Drain" von Wissenschaflter*innen in den USA als Chance für Deutschland.
Dieses Video ist nur auf deutsch erhältlich.
youtu.be/0GtZ_lfL8Rc?...

Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?

Funding call with deadline 15 June, decisions in July.

www.embl.org/about/info/s...

We’re thrilled to announce that the EMBL-EBI Thornton Building has been officially opened by Lord Vallance of Balham, the UK’s Minister for Science, Research and Innovation.

We hope it will be a space where collaboration, translation, and science can thrive! 🌱

I could not really motivate myself to start properly on Bluesky following my departure from twitter. Maybe this picture is a good place to start. Antwerpen central station. What a building m!! Looking forward to www.vibconferences.be/events/revol...

Really great collab with @moritzgerstung.bsky.social and Dana Pe’er lab. Excited to hear what you all think. Cell segmentation is just hard… more to
Come! Will also show a bit of it tomorrow at www.vibconferences.be/events/revol....

Next up: Melissa Sanabria on LLMs for genomic data. What is the best vocabulary to tokenise DNA sequences? #EESAIBio.

New Symposium on AI and Biology starting now! #EMBL #EESAIBio. www.embl.org/about/info/c...