Johanna Joyce Lab

White text on a black background: For me, the most inspiring part was seeing how many women are now leading the field of cancer research. I’ve attended conferences before, but this time, it felt different; there was a strong presence of women not just as attendees, but as keynote speakers, session chairs, and award recipients. It made me pause and realize how much the landscape is changing. As a young woman in science, it felt both empowering and motivating. It reminded me that we’re not just contributing, we’re also shaping the future of this field in a real and visible way.

As conference organisers, we just love to receive feedback like this anonymous comment from a trainee at our recent #EACR2025 Congress in Lisbon 😊

#WomeninSTEM #WomeninScience 🧪🔬👩🏻‍🔬👩🏼‍💻👩🏾‍⚕️👩‍🔬👩🏿‍🔬

@helloeacr.bsky.social

Truly honored to receive the 'Young Researcher in Basic Sciences Award' from the Faculty of Biology and Medicine, University of Lausanne! 🧠 ✨
Huge thanks to Johanna Joyce for her excellent mentorship, support, and inspiration — I’m incredibly grateful!
And congrats to all the other awardees! 🎉

CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis - Cell Research Cell Research - CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis

🧠 Neuro-immunology is reshaping how we understand the brain - across many diseases, including #cancer

In this research highlight 🧪🔬 we discuss a new study in #Nature by Remsik, Boire et al showing how IFNγ-activated immune cells in the CNS, incl DCs, help constrain leptomeningeal #metastasis

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

Written with @ahernandezb.bsky.social, a wonderful postdoc in my lab!

Many congratulations to @meningojan.bsky.social and @adrienneboire.bsky.social for this amazing publication:

www.nature.com/articles/s41...

Photo of Dr Leire Bejarano (left) receiving her award from Prof Margot Thome-Miazza (right)

Huge congratulations to Dr Leire Bejarano, an amazing postdoc from our lab, who received the "Young Researcher in Basic Sciences Award" from the Faculty of Biology & Medicine UNIL

Super proud of you @lbejarano.bsky.social !! 🎉🥳🤩

@fbm-unil.bsky.social @unil.bsky.social

www.unil.ch/news/1749042...

Excited to share our research highlight on leptomeningeal metastasis and how IFNγ-activated dendritic cells shape CNS immune control—featuring the latest from @adrienneboire.bsky.social and @meningojan.bsky.social—
A privilege to write this with @johannajoyce.bsky.social at @joycelab.bsky.social 🙏🧠🔬

The #career #discovery sessions are one of many great aspects of our #EACR Congress - and one of my favourite ways to chat with early career researchers!

We had a great discussion on "Efficient and caring mentorship: how to make your research team flourish"

#EACR2025
@helloeacr.bsky.social

The EACR Board is gathering this week in Lisbon to review the past year and look ahead to how we can continue benefiting our members and the wider cancer research community 🤩💙

Mini Joyce lab reunion at the #EACR Congress in Lisbon!

We were very happy to have presented our research, to learn about the latest major cancer discoveries, and also to reconnect with several of our alumni!

#EACR2025

Celebrating 2️⃣0️⃣ years of the Joyce Lab 🎉

We had an amazing reunion, bringing together past & present lab members from Lausanne & NYC 🏔️🗽

Huge thanks to everyone who came from around the world, shared science & happy memories and together made this milestone really special 😍

#JoyceLab20 #ProudMentor

Seeing everyone connect across generations, share their science & memories, and reflect on how far we've come - as a lab, and as individuals - was incredible

The diversity of successful career paths, and the lasting friendships that have grown from this lab, are something I feel deeply proud of ☺️

#joycelab20 #proudmentor | Johanna Joyce | 10 comments 20 amazing years of the Joyce Lab 🎉 We just celebrated two decades of the Joyce Lab with a very special reunion in the Swiss mountains, bringing together lab members past and present - from our early ...

Special thanks to the brilliant organising team of Myriam Piccard, Cátia Costa, @ale-matera.bsky.social @juliemmazet.bsky.social 🙏 🙌

20-yr T shirt design by the super talented Michelle Ballabio 🙏

Funding support from the amazing @ludwigcancer.bsky.social 🙏

www.linkedin.com/feed/update/...

And wonderful photos by our in-house photographers/ drone specialists 📷👏 @drspencerwatson.bsky.social @dolfibastien.bsky.social 🙏

This group photo was captured by drone - a J for Joyce lab 😉

My thanks again to ~50 alumni & current lab members who joined over the 3 days of this truly unique event!!

After a memorable journey in the Joyce Lab, it’s time to start a new adventure. I will always be grateful for the extraordinary mentorship and support of @johannajoyce.bsky.social. I'm excited to share that I will start as a #NewPI at the Biogipuzkoa HRI, in the beautiful city of San Sebastián 🙂

Wishing our amazing postdoc @lbejarano.bsky.social continued success and happiness - as she leaves us to start her own lab in Spain 🎉🥳

Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!

#NewPI 🤩
#ProudMentor 😊

Why Are Breast Cancers That Metastasize to the Brain Hard to Treat? Immunosuppressive factors prevent killer T cells from defeating brain tumors that arise from primary breast cancer.

Thanks to "The Scientist" for this great article covering a recent study from our lab where we explored why breast-to-brain metastases resist #immunotherapy — even when the same cancer type responds outside the brain.. 🧠🧪🔬

#brain #cancer #metastasis

www.the-scientist.com/why-are-brea...

We’re very proud of EACR President @yardenasamuels.bsky.social and President-Elect @johannajoyce.bsky.social delivering their fascinating plenary talks at @theaacr.bsky.social #AACR25 this week 👏 and of course our Treasurer Caroline Dive becoming an AACR Fellow. A memorable week in Chicago 🤩

Opening session of #AACR25 annual meeting - with all attendees raising signs in support of cancer research funding #CancerResearchSavesLives

Thanks to all at #AACR25 for an inspiring and impactful annual meeting!

Filled with cutting-edge science 🧪- and the direct impact of those discoveries for patients with #cancer

Special thanks to co-chairs @mvhlab.bsky.social @lilliansiu.bsky.social

#CancerResearchSavesLives

@theaacr.bsky.social

Unifying Cancer Science and Medicine: A Continuum of Innovation for Impact — Presenters discussed KRAS inhibition, ecDNA, the tumor microenvironment, and cancer vaccines in the #AACR25 Opening Plenary on Sunday. Read a recap in AACR Annual Meeting News: www.aacrmeetingnews.org/news/opening...

We all know how much the microenvironment matters!

So grateful that the #TME field has so many fantastic - and supportive - women leaders 🙌

#AACR2025 🧪⚕️
#womeninscience
#payitforward

@theaacr.bsky.social

Impressive opening plenary presentation from @johannajoyce.bsky.social on Unraveling the complexity of cancer ecosystems. She highlighted the importance of the fibrotic niche and potential therapeutic approaches that target it #AACR25

@johannajoyce.bsky.social giving a wonderful presentation about she and her team’s successful discoveries on immunosuppressive myeloid cell infiltration and their contribution to recurrence and progression of brain tumors and at the #aacr2025 Plenary Session

Ludwig @fbm-unil.bsky.social's @johannajoyce.bsky.social gave a plenary talk @ #AACR2025 on exploring the microenvironment of primary and metastatic brain tumors to expose vulnerabilities to target for novel therapies.

Looking forward to an exciting Opening Plenary Session today at #AACR25 - Unifying Cancer Science and Medicine 🧪⚕️

Many thanks to #AACR for the invitation to share our latest research:
"Unraveling the Complexity of Cancer Ecosystems"

@theaacr.bsky.social
@ludwigcancer.bsky.social

brnw.ch/21wRF7R

Wischnewski et al. demonstrated that CD8+ T cells infiltrated breast cancer brain metastases (BC-BrM), but failed to elicit an effective antitumor immune response, in contrast to genetically identical extracranial tumors. bit.ly/4lylK43   ‪@johannajoyce.bsky.social‬

Reprogramming the tumor microenvironment: a turning point in brain cancer research In Nature Medicine, Prof. Johanna A. Joyce reflects on her lab’s 2013 breakthrough showing that reprogramming, rather than eliminating, tumor-associated macrophages can slow glioblastoma—marking a…

🧠 En 2013, une étude révolutionnaire montrait qu’on pouvait reprogrammer les macrophages tumoraux dans le #glioblastome. Dans 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦, @johannajoyce.bsky.social revient sur cette découverte et son impact.

🔗 News: www.unil.ch/news/1744719...

🧬 In @natmedicine.bsky.social Johanna Joyce revisits her landmark 2013 glioblastoma study on #macrophage #reprogramming.

🔗 Original paper: www.nature.com/articles/s41...

@unil.bsky.social @ludwigcancer.bsky.social

Reprogramming the tumor immune microenvironment to treat glioblastoma - Nature Medicine Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.

Thanks to @natmedicine.bsky.social for inviting this 'Turning Point' as part of their 30-yr anniversary 🎉

Back in 2013, we published a Nat Med study that not only impacted the #tumor #microenvironment field, but also the trajectory of our lab 🧪

Led by a great team- Pyonteck, Akkari & Schuhmacher 🙌

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find disti...

New in @cp-immunity.bsky.social: Momentum Fellow Leire Bejarano Bosque of @joycelab.bsky.social maps brain tumor blood vessels to build a "vascular atlas" that highlights important differences between tumor types & will help researchers identify new therapeutic targets.
www.cell.com/immunity/ful...

The unveiling of vascular heterogeneity is depicted as a red pencil coloring in the intricate details of tumor-associated blood vessels within a map of the human brain wherein a tumor is surrounded by diverse immune cells.

New issue online! This beautiful cover depicts work from @johannajoyce.bsky.social @lbejarano.bsky.social
&co who use single-cell RNA sequencing & spatial analysis to construct a vascular atlas of primary & metastatic brain tumors. Art by @joanagcc.bsky.social
www.cell.com/immunity/iss...