Sanford Burnham Prebys

After comparing proteins in the bloodstreams of normal mice and mice lacking Mrc1, the team found the accumulation of 244 mannosylated blood plasma proteins to double or more of the amounts found in normal mice due to Mrc1 no longer keeping the levels in check. The scientists then took a closer look at the newly identified ligands. They used bioinformatics to review and depict these hundreds of proteins by their functions. Image credit: Jamey Marth and Mayank Saraswat, Sanford Burnham Prebys.

New research from the Marth Lab: Most blood glycoproteins are easy to spot—but finding the rare ones is like searching for Waldo across every book. 🧠🧬

🔗 Read more: sbpdiscovery.org/press/signal...

#Biomedicine #SanfordBurnhamPrebys #NatureCommunications #Science

Q & A with Postdoctoral Researcher Meena Sudhakaran, PhD, from the Kersten Lab - Sanford Burnham Prebys Meet one of our early-career scientists: Meena Sudhakaran, PhD. She studies cancer immunology to improve immunotherapy for breast cancer.

Meet Meena Sudhakaran, PhD, a postdoc in the Kersten Lab at Sanford Burnham Prebys. She’s advancing cancer immunology to improve immunotherapy for breast cancer. Read more about her journey into science: sbpdiscovery.org/q-and-a-with...
#CancerResearch #PostdocLife

Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by significant hepatic fibrosis and inf...

#ArticleinPress: Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis. @ucsandiego.bsky.social and @sbpdiscovery.bsky.social.

#OpenAccess text: ajp.amjpathol.org/article/S000...

A promising advance for pancreatic cancer published Cancer Cell: Blocking macropinocytosis reduces fibrosis around pancreatic tumors, improving immune cell access & boosting response to chemo & immunotherapy in mice. sbpdiscovery.org/press/reshap... @cosimocommisso.bsky.social @yijuan.bsky.social

Aashna Lamba - Lamba is investigating the use of genetic reprogramming to help the heart heal after being injured.

Ashley Neil - Neil is studying a neurotransmitter that influences brain cell inflammation and activity in Alzheimer's disease.

Big congrats to grad students Aashna Lamba & Ashley Neil at @SBPdiscovery—named 2025 CIRM Predoctoral Fellows! 🌟

Lamba’s research could help hearts heal after injury ❤️
Neil is exploring brain inflammation in Alzheimer’s 🧠

#SanfordBurnhamPrebys #RegenerativeMedicine #CIRM #STEM

Leading cancer and metabolic disease expert Michael Karin joins Sanford Burnham Prebys - Sanford Burnham Prebys Karin will direct the Center for Metabolic and Liver Diseases and continue his studies on inflammation and cancer.

📣 Welcome Michael Karin, Ph.D., to Sanford Burnham Prebys!
He joins as director of the new Center for Metabolic and Liver Diseases and will continue his pioneering work on chronic inflammation and cancer.
sbpdiscovery.org/press/leadin...

Opinion: Health database could provide key insights to improve care In every body and in everybody, there is an enormous, diverse and changing array of medical and health information, from longitudinal data like our weight and blood pressure over the years to the b…

What if the key to major medical breakthroughs is already sitting in clinical databases—just waiting to be unlocked?

Sanford Burnham Prebys CEO David Brenner shares why tapping into electronic health records could transform research and care.

Read more: www.sandiegouniontribune.com/2025/06/23/o...

Sanford Burnham Prebys celebrates newest graduate school alumni - Sanford Burnham Prebys The Graduate School of Biomedical Sciences held its 2025 Commencement ceremony to celebrate four recent graduates.

Cheers to the newest grads of the Sanford Burnham Prebys Graduate School of Biomedical Sciences! 🎓🔬♥️ Their hard work, perseverance, and curiosity reflect the spirit of our graduate program's motto: “Knowledge is the power to heal.” Congrats to these rising scientists. More: https://bit.ly/3HFmyEB

🧠 Could HIV drugs help lower #Alzheimer’s risk? New research from Sanford Burnham Prebys, led by Jerold Chun, MD, PhD, found that patients taking #HIV drugs blocking #reversetranscriptase had fewer cases of Alzheimer’s—pointing to a potential drug target. More: https://bit.ly/4kuxvHU

CIAO Study: Lessons learned on living longer and better (with more to come) - Sanford Burnham Prebys A select group of scientists from around the world gathered in the small town of Acciaroli in the Cilento-Salerno region of Italy to review a decade’s worth of research in the ongoing Cilento Initiative on Aging Outcomes (CIAO), a longitudinal study of local residents 100 years and older.

Centenarians in Cilento are thriving thanks to a Mediterranean way of life. The CIAO Study 🌿 reveals they’re biologically younger, with resilient immune systems & strong social ties—offering real clues to how we can all age better. More: https://bit.ly/45HjqCf #CIAOstudy #longevity #healthyaging

Evan Snyder named Fellow of the Child Neurology Society - Sanford Burnham Prebys Evan Snyder, MD, PhD, has been named a Fellow of the Child Neurology Society, honoring a distinguished career and significant contributions in the field of child neurology.

Evan Snyder, MD, PhD, professor in the Center for Neurologic Diseases at Sanford Burnham Prebys, was named a Fellow of the Child Neurology Society for his clinical expertise and pioneering research in #pediatricneuroscience and #stemcellbiology. 🧠

Learn more: 🔗 https://bit.ly/4jATHio

From cancer and aging to immunotherapy and AI, these new PhDs are already making an impact—and they’re just getting started.

👏 Learn more about how we’re training tomorrow’s scientists: vist.ly/3n5mjza

#SBPgrad #PhDlife #FutureOfScience #BiomedicalResearch #CancerResearch #Immunotherapy

Prebys Foundation awards $1 million to Sanford Burnham Prebys as part of emergency support to local biomedical research institutions - Sanford Burnham Prebys The Prebys Foundation announced this week an emergency response package totaling $7 million to seven leading research institutions in San Diego — a global hub and leader in biomedical science and innovation.

The Prebys Foundation has announced a $7M emergency funding package for seven top-tier biomedical research institutions in San Diego, a global hub of scientific innovation, including Sanford Burnham Prebys. Learn more: 🔗 https://bit.ly/4kiJ84H

🎙️ Catch Ani Deshpande, PhD, in episode 151 of the @epigeneticspod.bsky.social‬‬ where he discusses his work on epigenetic regulation in #AML, and the use of #CRISPR and high throughput screens for drug discovery.

▶️ YouTube: vist.ly/3n5jemi
ᯤ Spotify: vist.ly/3n5jemj

Scientists and podcasters - Sanford Burnham Prebys Sanford Burnham Prebys scientists Ani Deshpande, PhD, and Pamela Itkin-Ansari, PhD, bring dramatic stories of scientific achievement to life.

Check out our Q&A with scientists and podcasters Ani Deshpande & Pam Itkin-Ansari! Their podcast 𝑇ℎ𝑒 𝐷𝑖𝑠𝑐𝑜𝑣𝑒𝑟𝑦 𝐷𝑖𝑎𝑙𝑜𝑔𝑢𝑒𝑠 is blowing minds—venom, insulin, and Ozempic all in one. 🎧💉 Listen: https://bit.ly/3Fmu4nl

San Diego County supervisor & local researchers make voices heard on preserving NIH funding "We are here today to sound the alarm on the devastating cuts and disruptions to the National Institutes of Health,” Supervisor Terra Lawson-Remer said.

Cutting NIH funding means fewer cures, fewer trials, and slower progress. San Diego researchers are speaking out.
🧬 Dr. Kurt Marek of Sanford Burnham Prebys joined the call to protect science.

🔗 www.10news.com/news/local-n...
#FundScience #NIH

Doctoral-degree candidates visited Sanford Burnham Prebys for the Rising Stars Symposium—great opportunity to explore postdoc life at the Institute—featuring research talks, networking and a keynote from Mark Mercola, PhD, of @StanfordMedicine . Read more: vist.ly/3n4bs6w

Kelly Kersten, PhD, has received a grant from the Melanoma Research Alliance @melanomaresearch.bsky.social to study how to restore the function of exhausted #immunecells in #melanoma tumors. The award is part of MRA’s $9.3M research funding commitment for 2025. Learn more: 🔗 vist.ly/3n3ney9

📢 Calling all advanced graduate students and prospective postdocs! Thinking about your next move after grad school? We're hosting a Postdoc Virtual Open House 🖥️ on May 19, 2025, from 10:00 a.m. to 3:00 p.m. PT. Join us to learn more: 🔗 vist.ly/3n36wva

Researchers from the CIAO (Cilento Initiative on Aging Outcomes) study are gathering in Cilento, Italy📍 to mark 10 years of exploring what drives healthy aging and longevity. When your subjects live past 100, a decade of science is just the beginning. Read more: 🔗 vist.ly/3n3jq33

🚨 Just dropped on Radiolab!

Hudson Freeze, PhD, tells the wild true story of how a search for life in boiling water changed biology—and saved millions.

🎧 Listen here: vist.ly/3m2rymx

#Radiolab #SanfordBurnhamPrebys #ScienceMatters

Sanford Burnham Prebys hosted 𝘈 𝘊𝘰𝘯𝘷𝘦𝘳𝘴𝘢𝘵𝘪𝘰𝘯 𝘈𝘣𝘰𝘶𝘵: 𝘈𝘨𝘪𝘯𝘨 𝘢𝘯𝘥 𝘈𝘭𝘻𝘩𝘦𝘪𝘮𝘦𝘳’𝘴, featuring leading scientists and author Muffy Walker. The event highlighted advances in research and care. Watch the full program here: vist.ly/3m2n2ns

Alternative Thinking: Using Science to Fix Science A letter from David A. Brenner, MD, President and CEO of Sanford Burnham Prebys In a recent letter to Michael Kratsios, President Trump implored his 38-year-old director of the White House Office of Science and Technology Policy to “blaze a trail to the next frontiers of science.

NIH cuts and terminated grants undermine research on infectious diseases, vaccines, public health and more. David A. Brenner, PhD, president and CEO of Sanford Burnham Prebys provides his perspective: less science equals fewer breakthroughs resulting in weaker health outcomes: https://bit.ly/4jnAUaT

Cosimo Commisso, PhD, was featured on the @ProjectPurple Podcast, which includes conversations with pancreatic cancer survivors, physicians and researchers. Project Purple is a nonprofit focused on #pancreaticcancer research and support for patients and their families. More: https://bit.ly/3Y823pH

Our final March #TopRead is from Dr. Carl Ware, @sbpdiscovery.bsky.social, who described the first method to directly quantify the HVEM-BTLA cis-complex. Find it in The JI: ow.ly/nElT50VAjzY.

Episode 309: Unlocking the Science of Pancreatic Cancer with Dr. Cosimo Commisso Podcast Episode · Project Purple Podcast · 03/28/2025 · 55m

I joined the Project Purple Podcast to talk about how pancreatic cancer cells survive, how we can target them, and why research funding matters more than ever. Listen here: podcasts.apple.com/us/podcast/e...

Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities - Nature Reviews Cancer In this Review, Emerling and colleagues summarize the roles of phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) in cancer. They highlight the altered expression of these kinases in tumours and discuss ongoing efforts in developing therapies targeting these lesser-studied phosphoinositide kinase families.

#REVIEW 🚨


Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️

Graduate School of Biomedical Sciences - Sanford Burnham Prebys We are dedicated to educating the next generation of outstanding biomedical scientists who will drive future basic and translational research

This week, we observe #GraduateStudentAppreciationWeek. Our graduate students are integral to the Institute’s mission—to energize, accelerate and reimagine translational research. Join us in expressing gratitude for their outstanding contributions: https://bit.ly/42pzTaU 🧪🔬📚 🧫

The Queer Scientists and Allies Symposium was held at Sanford Burnham Prebys on April 4, 2025, connecting LGBTQIA+ researchers and showcasing their work. Local organizations also supported the event. Read more: 🔗 vist.ly/3mzhra7 🧑🏻‍🔬👨🏽‍🔬👩🏾‍🔬

The NIH's recent grant terminations have canceled hundreds of previously approved research projects, including studies on HIV, vaccine development and public health, posing a serious threat to research: https://bit.ly/42uiw9b

#NIH #publichealth #disease #medicalresearch #biomedicalresearch