Dan 🐟 C

We can now properly credit to @swinburnelab.bsky.social 🤩 Welcome to Bluesky! 🧪

JCS Cover: Cyri-b-knockout Cos-7 cells spread wide with actin-driven lamellipodia (blue), while microtubules (orange) do not always reach the cell edge, capturing the dynamic interplay of cytoskeletal systems. See article by J. A. Whitelaw et al. (jcs263646).

Issue 22 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows Cyri-b-knockout cells with actin-driven lamellipodia in blue and microtubules in orange. See article by Whitelaw, et al.
journals.biologists.com/jcs/article/...

Thanks Mathieu! We enjoyed your gill development paper, very nice work! and congratulations on the cover 🎉

Thanks Jason! 😊

Yup, they do.

Thanks 😊

Thanks Kevin! That’s very kind. 😊

Thanks Philipp!

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park!
“Specialized gas-exchange endothelium of the zebrafish gill” —

www.biorxiv.org/content/10.6...

Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

Soliciting recommendations for 3D printers and lab supply blue prints. Please share and RT.

Zebrafish are an excellent model for studying the development and function of blood and lymphatic vessels. Research in zebrafish has even led to treatments for lymphatic disorders in people. This image, taken using a powerful microscope that uses lasers to illuminate the fish, shows blood vessels (magenta) and lymphatic vessels (green) in the eye and head of an anesthetized, 6-week-old, transgenic zebrafish. Credit: Daniel Castranova, National Institute of Child Health and Human Development, NIH

#KnowYourZDM: In 2019, a 10-year-old patient w/ a life-threatening lymphatic disorder was losing hope. Zebrafish to the rescue! Scientists created zebrafish with the same gene mutation and found a melanoma drug that fixed the fish. Then, doctors used the same drug on the patient to save his life! 🧪

Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!

Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."

lnkd.in/gN7z6th4

Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish https://www.biorxiv.org/content/10.1101/2025.11.14.688311v1

“By performing longitudinal live imaging of intubated adult fish we observe vascular regrowth and immune responses to [meningeal cerebrovascular injuries] over time in the same animal with unprecedented resolution”

New work from #WeinsteinLab at NIH

Image of an adult zebrafish using discarded film slides. There are stripes of dark brown and blue capturing the essence of adult zebrafish

#ZebrafishFunFacts: Using the discarded slide film from his doctoral research, Professor and amateur artist Michael Barresi created a mosaic of an adult #zebrafish.

Learn about his upcoming art installation on human embryos called 'Using Art to Demystify Science': www.smith.edu/news-events/... 🧪

MDI Bio Lab’s Hannah Somers’ Image Wins International Recognition

Big congratulations to Hannah Somers, Digital Image Analyst at MDI Bio Lab, whose striking visualization of a zebrafish’s brain was named an Image of Distinction in the Nikon Small World competition — and featured by #NationalGeographic!

#researchmatters #microscopymonday #lightsheet 🧪 🤝 🐟🎸 👩‍🔬

Slow-mo video of zebrafish mating. Credit to
@zebrafish007.bsky.social. #ZebrafishZunday 🧪

Y’all saw it here on Bluesky FIRST.

Trailer for #GarWeek 2025.
JOIN US November 3-7!!!

Humans bearing mutations in vascular endothelial growth factor C (VEGFC) or its receptor tyrosine kinase (FLT4) have defects in the formation of their lymphatic system, which is important for draining interstitial fluid back into the circulatory system. As a consequence, these patients display severe lymphedema (bottom left). In zebrafish, we have generated mutations in vegfc and flt4, both of which are conserved between zebrafish and humans. Like humans, zebrafish larvae also display lymphedema due to a failure to form a complete lymphatic system (bottom right). Credit image and text to Prof. Nathan Lawson @LawsonZFLab https://www.umassmed.edu/lawson-lab/zebrafishmodel/disease-models/

#KnowYourZDM: Humans and #zebrafish carrying mutations in VEGFC or its receptor (FLT4) have defects in the formation of their lymphatic systems, which are important for draining lymph back into the circulation system.  As a result, these individuals display severe #lymphedema. 🧪

Endocardium, cells lining the heart chambers, in the beating heart of a two-day-old transgenic #zebrafish. Credit to @anjaliesch.bsky.social & Nikon Small World Competition. #ZebrafishZunday 🧪

Wow!! Looks awesome 😎

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

You’re not ready for gar slime:

@scadsai.bsky.social training coordinator @haesleinhuepf.bsky.social provided insights into his professional career in the podcast series “The Microscopists.”
If you want to know why he'll never ask biologists for better images again, click here:
🍍 themicroscopists.bitesizebio.com/episodes/rob...

Eda overexpression causes precocious tooth differentiation in sticklebacks. (A,B) at 9 dpf, Eda OE fish (n=9) demonstrated precocious oral tooth germs relative to control fish (n=10). Images show eGFP from the dlx2b tooth reporter and mCherry from the OE transgene. A’ and B’ show the fish indicated in A and B in greater detail. Black arrowheads indicate pioneer tooth germs. (C) at 12 dpf in WT, pairs of germs are observed on the premaxilla and dentary (black arrowheads), similar to the condition seen in the 9 dpf Eda OE fish, suggesting these represent accelerated endogenous teeth. Sale bars=100 μm.

Wrong place, right time: Eda drives ectopic teeth formation in fish
This Research Highlight showcases the work from Tyler Square and colleagues: journals.biologists.com/dev/article/...

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

Sure! Enjoy!

Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...