Roberta Azzarelli

The Possible vs. The Actual: can #GenerativeBiology reveal fundamental design principles of complex life?

@philipcball.bsky.social closes #GenBio25 with a magnificent synthesis of the past two days of discussions, and guides us towards an agenda for the future of the field.

Excited to share our latest work with @jamesbriscoe.bsky.social .

A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord.

Congrats to all authors.

Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1 | Open Biology ASCL1 is a key member of the proneural basic helix-loop-helix (bHLH) transcription factor (TF) family and it plays diverse roles in nervous system development and maintenance. ASCL1 is also one of the...

Glad to share our review on Cell fate acquisition and reprogramming by ASCL1

Big shout out to Jethro Lundie-Brown, Francesca Puletti and Anna Philpott

Collaboration between @scicambridge.bsky.com @ucl.ac.uk @ucllifesciences.bsky.com School of Pharmacy

royalsocietypublishing.org/doi/10.1098/...

A pleasure to host the Jean Banister Prize Lecture @ucl.ac.uk School of Pharmacy
Thank you Sylvia for a fantastic lecture! And many thanks to Annette, Mala Shah and the Physiological Society
@sylviaschroeder.bsky.social @annieneuro.bsky.social @physoc.bsky.social

Thanks to Marreo Carandini for the photo

Great lecture on visual processing given by @sylviaschroeder.bsky.social
She is the winner of 2025 R Jean Banister prize for early career scientists, awarded by @physoc.bsky.social .

Congratulations @sangjokang.bsky.social and #zoulab for this pioneering study on how #microglia shape invasion of brain cancer through cell collision mechanism via Plexin-B2. 축하해요 ! www.nature.com/articles/s43...
@sinaibrain.bsky.social

🧠 ‘How vision is shaped by behaviour and internal states’ 🧠

All welcome! Looking forward to it!

Please mark this in your calendar! 👇🏼
Wed 11th June 4pm @ucllifesciences.bsky.social School of Pharmacy, we host R Jean Banister Prize Lecture @physoc.bsky.social from Dr Sylvia Schroeder
@sylviaschroeder.bsky.social Uni of Sussex

Please join us for the next Pharmacology seminar series @ucl.ac.uk @ucllifesciences.bsky.social School of Pharmacy

Dr Irving Aye will talk on Metabolic control of epigenetics in placenta on 21st of May! Coming very soon!!

And to round off the day, the perfect conclusion to our symposium, a broad exploration and thorough discourse of the history and state of the art in molecular developmental haematology from Prof. @BertieGottgens of Cambridge Stem Cell Institute.

#science #research

Invited speaker Prof. Selina Wray leading Session 2: Stem cell models of health and disease. An exciting journey through her use of, and novel insights from, patient-derived iPSC models of Alzheimer’s Disease.

Symposium kicked off with an energising Flagship Lecture from @inesequeira.bsky.social , presenting work decoding epithelial tissue regeneration and cell type heterogeneity using multi-omic and cellular dynamics data.

Did I say that the Pharmacology seminar series @ucl.ac.uk @ucllifesciences.bsky.social School of Pharmacy is in full swing?

Yes. After the success of @MootazSalman, we will have @MikkoAiravaara 16thApril and @IrvingAye 21stMay (none on bsky yet 😊)

The Pharmacology seminar series @ucl.ac.uk @ucllifesciences.bsky.social School of Pharmacy is in full swing!

Thank you @MootazSalman @ox.ac.uk for a fantastic seminar! Contagious enthusiasm and great science! Thank you for coming!
And thanks to Prof. Afia Ali for bringing him in!

Discover how our researchers are creating real-world impact, developing innovative solutions to tackle humanity's most pressing challenges.
Watch the full video here: shorturl.at/mYLQV

📢Registration for #LSCN2025 is now open! We have a fantastic lineup of speakers and more to be confirmed!

Secure your place today eventbrite.co.uk/e/8th-annual... and submit your abstract for a chance to present your #stemcell work docs.google.com/forms/d/e/1F...

London Stem Cell Network @lscn.bsky.social is on Bsky! Hello! Please follow☝🏻 if interested in stem cells

Confocal microscope image of a mouse embryonic kidney section identifying the metanephric mesenchyme (WT1+, cyan) and the ureteric bud epithelium (CDH1+, magenta) during early renal branching morphogenesis. See Research article by Franks and Allen

Issue 24 is complete!

On the cover: Confocal microscope image of a mouse embryonic kidney section identifying the metanephric mesenchyme (WT1+, cyan) and the ureteric bud epithelium (CDH1+, magenta) during early renal branching morphogenesis. See article by Franks & Allen:
doi.org/10.1242/dev....

😂 so true..

Figure 1 (C) Representative immunostaining images for Tubb3 (green) in ESCs in pluripotency, NE and MS after 48 h of WT or SA ASCL1 induction or in control cells. DAPI nuclear counterstain (blue). Scale bars: 100 μm.

ASCL1 is a better chromatin remodeller when unphosphorylated

Read this Research Highlight showcasing work from Roberta Azzarelli (@robertazzarelli.bsky.social @ucllifesciences.bsky.social), Anna Philpott and colleagues:
https://journals.biologists.com/dev/article/151/24/e151_e2401/363434/

Please add me, thank you!

And I should not forget to thank the Cambridge community at the Stem Cell Institute and the UCL community at the School of Pharmacy for creating supporting and welcoming environments @ucllifesciences.bsky.social

The people behind the papers – Roberta Azzarelli and Anna Philpott ASCL1 is a pioneer factor that can reprogram somatic cells to produce neurons. Preventing ASCL1 from being phosphorylated appears to enhance its reprogramming abilities, but the reason for this is unc...

And the interview here 🫣

journals.biologists.com/dev/article/...

ASCL1 is a better chromatin remodeller when unphosphorylated ASCL1 can reprogram somatic cells into neurons by opening chromatin at inaccessible sites. This reprogramming ability can be enhanced by preventing ASCL1 from being phosphorylated. However, the molecu...

Research highlight summarises it all. Thanks @dev-journal.bsky.social 😍

journals.biologists.com/dev/article/...

Thanks to all the authors, Anna Philpott, the reviewers and the fantastic team at Development!

Could not be happier to share our recent paper in Development @dev-journal.bsky.social @biologists.bsky.social as my first post here!

journals.biologists.com/dev/article/...