bioRxiv Biophysics

Alternative probe chemistries for single-molecule analysis of long non-coding RNA https://www.biorxiv.org/content/10.64898/2025.12.04.691911v1

Sequence-context-aware decoding enables robust reconstruction of protein dynamics from crystallographic B-factors https://www.biorxiv.org/content/10.64898/2025.12.05.692009v1

Chart Builder: An Interactive Tool for User Driven Data Visualization in the Electron Microscopy Data Bank https://www.biorxiv.org/content/10.64898/2025.12.03.691848v1

Structural basis of Retron-Eco8-mediated anti-phage defense https://www.biorxiv.org/content/10.64898/2025.12.04.692459v1

Energetic Constraints in the Enzymatic Depolymerization of Crystalline PET https://www.biorxiv.org/content/10.64898/2025.12.05.692578v1

Prediction of biomolecule kinetics using physics-based Brownian dynamics to data-driven machine learning methods https://www.biorxiv.org/content/10.64898/2025.12.03.692248v1

Information Network Flux interprets the importance of regulatory circuits in the protein and gene spaces https://www.biorxiv.org/content/10.64898/2025.12.03.692218v1

Non-invasive Biomechanical Characterization of Embryos Using Microfluidic Cantilevers https://www.biorxiv.org/content/10.64898/2025.12.02.691595v1

Structural Basis of Inhibition and Desensitization in Heteromeric Kainate Receptors https://www.biorxiv.org/content/10.64898/2025.12.02.691905v1

The Emergence of Novel Versus Known Three-Dimensional Structures from Random Sequences. https://www.biorxiv.org/content/10.64898/2025.12.04.691947v1

Cryo-electron microscopy ensemble optimization using individual particles and physical constraints https://www.biorxiv.org/content/10.64898/2025.12.02.691891v1

Native Mass Spectrometry Analysis of a Cullin RING Ubiquitin E3 Ligase Complex in the Context of Targeted Protein Degradation https://www.biorxiv.org/content/10.64898/2025.12.04.692288v1

Surface phase separation in a confined space https://www.biorxiv.org/content/10.64898/2025.12.03.692075v1

Type III secretion system effector evolved to be mechanically labile and initiate unfolding from the N-terminus. https://www.biorxiv.org/content/10.64898/2025.12.03.691928v1

Emergent simplicities in an individual cell's stochastic response to disruptive change https://www.biorxiv.org/content/10.64898/2025.11.23.690018v1

Solution Structure of the Novel CH-domain zinc finger from the puberty regulator Makorin-3 https://www.biorxiv.org/content/10.64898/2025.12.01.691648v1

Soluble, but not precursor EGF induces intracrine signaling of the EGFR https://www.biorxiv.org/content/10.1101/2025.11.28.691129v1

Determinants of Protein-Level Parameters Governing MS2 VLP Reassembly https://www.biorxiv.org/content/10.64898/2025.12.02.691839v1

Liquid Crystal-like self-organization of Glioblastoma Prevents cell density induced migratory arrest https://www.biorxiv.org/content/10.64898/2025.12.01.691550v1

Robust brain complexity measurement using T2* informed multivariate sample entropy from multi-echo BOLD fMRI https://www.biorxiv.org/content/10.64898/2025.11.29.691196v1

Electrodiffusion active pump model with asymmetric immersed chemical potentials https://www.biorxiv.org/content/10.64898/2025.11.30.691367v1

Imaging Data-based Model Description Combining OptimalTransport and Phase-field Model https://www.biorxiv.org/content/10.64898/2025.11.30.691255v1

IcmX Plug Ejection in L. pneumophila's Type IV Secretion System: Is It Possible? https://www.biorxiv.org/content/10.64898/2025.11.30.691423v1

Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing https://www.biorxiv.org/content/10.1101/2025.11.27.690701v1

The pKa values of buried ionizable amino acids can be determined by the thermodynamic stability of the protein https://www.biorxiv.org/content/10.64898/2025.11.30.690581v1

Glycosylation-Modulated Conformational Diversity in Neurotrophin Receptors https://www.biorxiv.org/content/10.64898/2025.11.29.691319v1

Design of Allosteric Inhibitors for Mutant EGFR by Combined use of Machine Learning and Molecular Dynamics Simulations https://www.biorxiv.org/content/10.64898/2025.12.01.691623v1

Distinguishing near- versus off-critical phase behaviors of intrinsically disordered proteins https://www.biorxiv.org/content/10.64898/2025.12.01.691696v1

Emergent Morphologies, Slow Dynamics, and Phase Behavior in Dps:DNA assemblies https://www.biorxiv.org/content/10.64898/2025.11.28.691232v1

Mechanism underlying the ultralow energy-consumption rapid ion dehydration for the high flux of KcsA potassium channels https://www.biorxiv.org/content/10.1101/2025.11.30.691452v1