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Tempera_Lab

@itphilly.bsky.social

We’re a virology and chromatin lab digging into how Epstein-Barr Virus (EBV) rewires the host cell to cause cancer. We mix epigenetics, 3D genome biology, and metabolism to figure out how it all works—and how to stop it.

39 Followers  |  74 Following  |  3 Posts  |  Joined: 14.11.2024  |  1.5482

Latest posts by itphilly.bsky.social on Bluesky

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Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV associated gastric cancer Epstein-Barr virus associated gastric cancer (EBVaGC) accounts for ∼9–10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA....

🧬 New from our Lab!
Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling.

#Epigenetics #EBV #CancerResearch
www.biorxiv.org/content/10.1...

21.10.2025 18:05 — 👍 3    🔁 0    💬 0    📌 0

Thank you

13.07.2025 20:49 — 👍 0    🔁 0    💬 0    📌 0
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EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu

We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...

13.07.2025 00:54 — 👍 9    🔁 2    💬 1    📌 0
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RFK Jr. comes ‘home’ to his anti-vaccine group, commits to ‘a break’ for U.S. infectious disease research He has suggested without evidence that researchers and pharmaceutical companies are driven by profit to neglect chronic conditions.

RFK Jr.: “Thank you [to the NIH] for public service. We’re going to give infectious disease a break for about eight years.”

Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles.

www.nbcnews.com/politics/pol...

17.11.2024 14:45 — 👍 3613    🔁 1386    💬 753    📌 932

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