Aging and Metabolism

Check out the recent publication in Nature related to the effects of sterilization on lifespan. Michael Stout contributed to this report from an international team lead by Mike Garratt (University of Otago, New Zealand)

Edward F. Adolph Distinguished Lecture. Protein and energy metabolism: a state of flux | Journal of Applied Physiology | American Physiological Society Physiology processes are integrated, dynamic, and periodic and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological stud...

From our own Dr. Benjamin Miller's Edward F. Adolph Distinguished Lecture- Protein and energy metabolism: a state of flux @benjaminfmiller.bsky.social journals.physiology.org/doi/full/10....

Multidimensional Modeling to Maximize Adaptations to eXercise: The M3AX Trial Rationale and Study Design | Journal of Applied Physiology | American Physiological Society Age-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments compromising intrinsic capacity, healthspan and q...

Why do some people get massive gains from exercise while others see little change? 🤔
The M^3AX Trial is diving into the "Inter-individual Response Heterogeneity" to figure out how to maximize adaptations to exercise, especially as we age. journals.physiology.org/doi/abs/10.1...

OMRF scientist named to international research academy Benjamin Miller, Ph.D., inducted into the Academy for Health and Lifespan Research

Huge congratulations to our very own Dr. Benjamin Miller on his induction into the prestigious Academy for Health and Lifespan Research! 🎉 His groundbreaking work is at the forefront of extending human healthspan. @omrf.bsky.social
omrf.org/2025/05/19/o...

With a new three-year grant from the American Heart Association, OMRF's Dr. Kamil Kobak will study a common and life-threatening heart condition. 🫀

Read more: omrf.org/2025/05/15/o...

U.S. Rep. Stephanie Bice highlighted OMRF at a congressional budget hearing yesterday involving the U.S. Department of Health and Human Services, which includes the National Institutes of Health.

We thank you for sharing the vital impact and importance of biomedical research.

2025 Study section tracking

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

Grateful for the award! A major thanks to the Multiplexing Protein Analysis Core and folks at @am-omrf.bsky.social (like @benjaminfmiller.bsky.social) who were instrumental in gathering preliminary data for our NIH grant proposal.

Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice - GeroScience Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive oxygen species production, inflammation, and fibrosis, which eventually result...

Recent paper from the Stout lab reveals Canagliflozin, a diabetes drug, may delay ovarian aging by preserving follicular reserves and improving mitochondrial function. Could this hold promise for delaying menopause and systemic aging in women? 🧬
link.springer.com/article/10.1...

Frontiers | The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis

Exciting progress in ALS research from the Van Remmen lab! This study demonstrates that the nitrone compound OKN-007 delays motor neuron loss and slows disease progression in a mouse model of amyotrophic lateral sclerosis.
www.frontiersin.org/journals/neu...

The expanding roles of myonuclei in adult skeletal muscle health and function Skeletal muscle cells (myofibers) require multiple nuclei to support a cytoplasmic volume that is larger than other mononuclear cell types. It is dogmatic that mammalian resident myonuclei rely on ste...

First post on Bluesky! Congrats to Aga Borowik and Miller Lab on this thoughtful and thought provoking piece “The expanding roles of myonuclei in adult skeletal muscle health and function” portlandpress.com/biochemsoctr... @myoblue.bsky.social @am-omrf.bsky.social @omrf.bsky.social

It was an excellent seminar! Thank you for visiting!

I visited the Oklahoma Medical Research Foundation (OMRF) today. Incredible place! Thank you Magdalena Bieniasz for the invitation. Great to meet with Joan Walker, Doris Bennrook, Bethany Hannafon, Maureen Cox, Xin Zhang, and Priyabrata Mukherjee. @omrf.bsky.social @am-omrf.bsky.social

Congratulations, Weronika! It’s well deserved!

Reactive oxygen species in skeletal muscle injury, fatigue, regeneration and ageing: In memory of John Faulkner One of the most critical factors impacting healthspan in the elderly is the loss of muscle mass and function, clinically referred to as sarcopenia. Mu…

A new review from the Van Remmen lab. Everything you wanted to know about ROS and oxidative stress in muscle ⤵️
www.sciencedirect.com/science/arti...

We are all going to Alaska!! #AGE2025 as organized by the indomitable Ben Miller at OMRF @benjaminfmiller.bsky.social @americanaging.bsky.social @am-omrf.bsky.social

Check it out ⤵️
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy

How cool is this?? OMRF has its own scientific relic, located in the heart of the Aging and Metabolism Program.

Welcome to all our new followers and thanks to @brunetlab.bsky.social for adding us to the Aging Research starter pack!

Aging starter pack!

go.bsky.app/5UXXaDA

Congratulations to Dr. Wan Hee Yoon! For those not familiar, BSF brings together American and Israeli scientists and researchers for innovative partnerships that enhance the advancement of scientific breakthroughs.

OMRF discovers new chemical link to Alzheimer’s Findings may explain mood changes that precede disease

You got it!
omrf.org/2024/11/12/o...

Where did we get our profile picture? The foyer at OMRF has an amazing artistic cell representation with inlaid marble #mitochondria

VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction - Nature Communications Recent studies unexpectedly indicate involvement of ventral tegmental area dopamine neurons in Alzheimer’s disease (AD). Here, the authors identified the enzyme casein kinase 2 as a mechanistic link b...

New research in Nature Communications shows how SK channel dysfunction makes dopamine neurons hyperexcitable in a mouse model of Alzheimer's. Could this be a key to understanding cognitive decline? 🤔 #Alzheimers #Neuroscience #Dopamine
@mikebeckstead.bsky.social
www.nature.com/articles/s41...

Dr. Sue Bodine presented updates of the MoTrPAC at today’s 21st Annual Harold Hamm Diabetes Research Symposium #MoTrPAC

OMRF discovers new chemical link to Alzheimer’s Findings may explain mood changes that precede disease

How’s this for a first post?
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...