RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life Abstract. Archaea, a domain of microorganisms found in diverse environments, including the human microbiome, represent the closest known prokaryotic relati

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life url: academic.oup.com/nar/article/...

#Communiqué 🗞️ Une équipe de chercheurs a identifié le plus ancien vomi fossile terrestre connu à ce jour. Daté d’environ 290 millions d’années (Permien inférieur), soit plusieurs dizaines de millions d’années avant l’apparition des dinosaures.

👉 www.cnrs.fr/fr/presse/un...

Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Lawrence et al. examine how ribosome production in the eukaryotic nucleolus is coordinated by cytoplasmic processes to maintain appropriate ribosome numbers. The authors highlight regulatory inputs from cytoplasmic signaling, mitosis, and cytoplasmic organelles that converge on nucleolar function, and they discuss how disruption of these pathways contributes to human disease.

Online Now: Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Online now:

Iron Sulfides Produced by Thermococcales: An Iron Detoxification Mechanism Thermococcales, archaea from hydrothermal vents, promote iron sulfide precipitation, enabling survival in iron-rich environments. Some cells become encrusted in pyrite and do not survive mineralizati...

Iron Sulfides Produced by Thermococcales: An Iron Detoxification Mechanism enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond.

We extend our deepest condolences to his family, friends, and colleagues.

www.embl.org/news/people-...

"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...

Archaeal ribosome hibernation factors on the roll lately, check out the SriA, C; SirB, D with distinct ribosome binding #ribosome #RNASky

A dual-factor complex governs archaeal ribosome hibernation by sensing energy status https://www.biorxiv.org/content/10.64898/2026.01.19.700304v1

Fluidité intracellulaire et pouvoir infectieux du champignon Candida albicans Dans un article publié dans la revue Nature Microbiology, des scientifiques mettent en évidence un mécanisme jusque-là inconnu chez Candida albic

#ResultatScientifique🔎| Quand Candida albicans réduit ses ribosomes, ses cellules deviennent plus fluides, ce qui l’aide à changer de forme et à mieux infecter l’organisme 🍄
✍️ Robert Arkowitz
📕 @natmicrobiol.nature.com | buff.ly/zPSLael

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain https://www.biorxiv.org/content/10.64898/2025.12.25.696519v1

Lehrstühle an Universitäten: Schafft die Lehrstühle ab! Hierarchien an den Unis sind starr und ungerecht. Manche Hochschulen machen es längst besser.

Lehrstühle an Universitäten: Schafft die Lehrstühle ab! | DIE ZEIT share.google/IJOmJmSPit8Q...

Localised activity of reverse gyrase at gene regulatory elements DNA topoisomerases are essential enzymes found in all cells, where they regulate DNA supercoiling. Reverse gyrase (RG) is a unique type of topoisomerase that introduces positive supercoils into DNA an...

Delighted to share our new preprint: www.biorxiv.org/content/10.6...
We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky

Evolutionary Flexibility of Ribosome Biogenesis in Bacteria Abstract. Ribosomes are essential for protein synthesis and require ribosome biogenesis factors for assembly. To uncover the evolutionary diversity of ribo

Evolutionary Flexibility of Ribosome Biogenesis in Bacteria | Molecular Biology and Evolution | Oxford Academic https://academic.oup.com/mbe/article/42/11/msaf288/8340222?login=false

Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE

Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis https://www.biorxiv.org/content/10.1101/2025.11.24.690127v1

Computational design of cysteine proteases https://www.biorxiv.org/content/10.1101/2025.11.21.689808v1

Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...

An archaeal genetic code with all TAG codons as pyrrolysine Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...

An archaeal genetic code with all TAG codons as pyrrolysine www.science.org/doi/abs/10.1... #jcampubs

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg!

Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/

Hundred-Picolitre Droplet on Demand Tape Drive and XES Prototypes for Time-Resolved Serial Crystallography at VMXi, Diamond Light Source https://www.biorxiv.org/content/10.1101/2025.11.19.689295v1

Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1

Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...

Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases www.science.org/doi/abs/10.1... #jcampubs

Thermophiles don’t just survive heat, they thrive in it. 🔥

They provide heat-stable enzymes, insights into early Earth, and tools for biotech.

Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL

Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages https://www.biorxiv.org/content/10.1101/2025.11.11.687807v1

The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes https://www.biorxiv.org/content/10.1101/2025.11.07.687168v1

The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation https://www.biorxiv.org/content/10.1101/2025.11.07.687187v1

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.