Cell Biology J-Club

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagatio...

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain: Cell www.cell.com/cell/fulltex...

www.biorxiv.org/content/10.6...

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

www.biorxiv.org/content/10.1...

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

www.nature.com/articles/s41...

Hierarchical membrane-chromatin tethering buffers nuclear envelope assembly against alterations in lipid flux www.biorxiv.org/content/10.6...

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

RNA-specific local translation is patterned by condensates for multinucleate cell growth
www.nature.com/articles/s41...

Optogenetic control of PLC-γ1 activity directs cell motility www.biorxiv.org/content/10.1...

The Golgi Network, Volume II This book explores the interaction of Golgi with different organelles such as ER, the vesicular system, and protein complexes that execute these tasks.

A wonderful collection of contemporary topics and perspectives on secretion and Golgi biology edited by Akihiko Nakano and Jaakko Saraste.
The Golgi Network, Volume II @SN and link.springer.com/book/10.1007...

www.nature.com/articles/s41...

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling www.biorxiv.org/content/10.6...

Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition | PNAS www.pnas.org/doi/10.1073/...

Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin | PNAS www.pnas.org/doi/10.1073/...

Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis Bridge-like lipid transfer proteins transport lipids at membrane contact sites, but how they are targeted to these sites is not well understood. Dziurdzik,

Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis url: rupress.org/jcb/article-...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
www.nature.com/articles/s41...

In @eLife.bsky.social: Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons doi.org/10.7554/eLif...

Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS www.pnas.org/doi/10.1073/...

STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch - The EMBO Journal Membrane contact sites (MCS) are dynamic regions where the membranes of two organelles come into close apposition. MCSs play many roles in cellular homeostasis by facilitating inter-organelle lipid ex...

link.springer.com/article/10.1...

PML targets and resolves structured protein inclusions to mitigate neurodegeneration - Nature Cell Biology Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML i...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

A lineage-specific selective autophagy receptor module mediates P-body turnover Abdrakhmanov et al. identify a lineage-specific autophagy receptor module that mediates the selective recycling of P-bodies in the liverwort Marchantia polymorpha. The conserved decapping factors EDC4...

A lineage-specific selective autophagy receptor module mediates P-body turnover: Developmental Cell www.cell.com/developmenta...

The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics | PNAS Nuclear Envelope Membrane Protein 1 (NEMP1) is crucial for metazoan fertility; loss of Nemp1 causes death of primordial oocytes that reside in the ...

The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics | PNAS www.pnas.org/doi/10.1073/...

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

www.nature.com/articles/s41...

DAPL1 restrains RPE PANoptosis in experimental AMD by inhibiting GRP75-mediated mitochondria-associated endoplasmic reticulum membranes | PNAS www.pnas.org/doi/10.1073/...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

Membrane lipid composition and endocytosis modulate Wingless release from secreting cells www.biorxiv.org/content/10.6...

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex: Cell www.cell.com/cell/fulltex...

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition - The EMBO Journal In pulmonary fibrosis lung tissue is thickened and scarred, and the lungs become progressively stiffer and smaller, leading to low levels of blood oxygen and shortness of breath. Lung fibrosis is not ...

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition
link.springer.com/article/10.1...

Conformational biosensors delineate endosomal G protein regulation by GPCRs
www.nature.com/articles/s41...