Hart Jackson

Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Screenshot of paper title

Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.

Paper: www.nature.com/articles/s41...

Thanks to @sinaihealth.bsky.social

Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour–microenvironment interactions within t...

New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.

biorxiv.org/content/10.1...

@standardbiology.bsky.social #SpatialBio #IMC

🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦

Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.

👉 apply.interfolio.com/168307

The cell-division cycle is faster in cell types prone to forming cancer Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.

Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer.
www.nature.com/articles/d41...

🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation.

Apply ➡️ apply.interfolio.com/162929
or DM with questions!

Canada at this point needs to double research money to become a true powerhouse. In terms of dollars, it’s not a lot to get there. A visionary government would leap at the chance. Alas no party in Canada has that vision. Most institutions are freezing hiring (in ON anyways).

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer - Nature Communications In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tum...

So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:

You must not be pondering weird enough.

Need better clusters from your segmented single cell data?

Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells.

Great and highly useful work by Jett Lee!

in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2

Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.

Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...

CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
1/
www.nature.com/articles/s41...

Hi Richard 🙋‍♂️ can you add me too please?

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1 The tumor microenvironment (TME) is a complex network of interactions between malignant and host cel

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1

One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab

Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq

#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW

New to the field but would be nice to be added!

@kieranrcampbell.bsky.social would be a good addition!

Advanced methods in bioimage analysis 14 to 19 of september 2025

Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.

Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!

Would be great to join!

Profound synthetic lethality between SMARCAL1 and FANCM Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1 and FANCM. Their combined loss leads to catastrophic genome instability, particularly at simple-repeat sequence...

First post here!
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months! ome.github.io/ome2024-ngff...

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬

Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.