Susan Hafenstein

Impressive work!

You want to build an apparatus for time-resolved cryo-EM?
Easy:
bio-protocol.org/en/bpdetail?...

Protein production for cryoEM structure determination just got a lot cheaper - high resolution structure from half a plate of HEK cells with the "MIcro ISolation (MISO)" microfluidics-based approach. Congrats to the Brunner and Efremov labs in Brussels! www.biorxiv.org/content/10.1...

Do you know if the recording will be made available? I missed the last few talks.

David Goodsell's work (and career) are such an inspiration. So many of us have experienced the molecular world through his brush🖌️👨‍🎨🫶. I'm happy to see @jiwasa.bsky.social picking up the torch for @rcsbpdb.bsky.social's "Molecule of the Month"🧪🧶🧬

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇

Watch how the measles outbreak spreads when kids get vaccinated – and when they don't If you take 10 communities and run a simulation, it’s easy to see why we need as many members of the ‘herd’ as possible to get vaccines – before it’s too late

Beautiful simulation to explain why vaccine coverage matters

www.theguardian.com/society/ng-i...

From The Lab Party - happy holidays to all!

Photo of the Bhella lab in fancy dress as "Guns and Roses"

Delighted by this year's return to form for my lab, winning the fancy dress competition at the @cvrinfo.bsky.social Christmas party. The theme was music and we chose to go as "Guns and Roses"

David Baker chats with Rosetta folks

Nobel Laureates in Chemistry David Baker, Demis Hassabis, and John Jumper

David Baker visits all the Rosetta folks after his Nobel lecture. And photo of all three Chemistry laureates - David Baker, Demis Hassabis, and John Jumper. An honor to be here in Stockholm to see this.

Hello Bluesky!
We're the Plevka Lab, a structural virology research group at CEITEC. Using techniques like SPA #cryo-EM and #cryo-ET 🔬, we explore the fascinating structures of viruses to uncover their secrets. Follow us for research updates, insights, and a glimpse into the world of #virology! 🧫 🦠

Hundreds of workers, some in high viz vests, cover the floor of Notre Dame cathedral with a photo taken from above, looking down the length of the restored building.

An incredible photo posted today by French President Emmanuel Macron.

The floor of Notre Dame Cathedral is filled with the workers involved in the 5 year project to restore the building following the devastating fire in 2019.

1/2

two men are standing in a park and one of them is asking the other " how is that possible " ALT: two men are standing in a park and one of them is asking the other " how is that possible "

I am at that stage of this proposal where I think this is the best thing I’ve ever written and 5 minutes later, I think this is the worst thing I’ve ever written.

Somehow, both feelings are accurate

Greatly enjoying our ongoing #cryoET adventures. My new favourite way to procrastinate from administrative tasks is to play I spy with @bobcoelingh.bsky.social's recent data set! 👀

Here's an easy one! 👇

Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution - Nature Microbiology Deep mutational scanning of Enterovirus A71 maps and quantifies the impact of genomic insertions, deletions and substitutions on virus fitness and highlights the role of insertions and deletions in th...

This is exactly what we need for polyomaviruse!

www.nature.com/articles/s41...

HPV vaccines linked to drop in cervical cancer deaths From 2013-2015 to 2019-2021, mortality decreased 15% per year.

HPV vaccines linked to drop in cervical cancer deaths www.cidrap.umn.edu/human-papill...

Hidden players: the bacteria-killing viruses of the gut microbiome Viruses known as bacteriophages are difficult to study, but they are beginning to give up their secrets.

All the world's a phage:
www.nature.com/articles/d41...

Canine parvovirus NS1 induces host translation shutoff by reducing mTOR phosphorylation | Journal of Virology Autonomous parvoviruses, which possess compact genomes, are obligate intracellular parasites that necessitate host cell division for their replication cycle. Consequently, the modulation of host translation and usurpation of cellular machinery are ...

Canine parvovirus NS1 induces host translation shutoff by reducing mTOR phosphorylation journals.asm.org/doi/10.1128/...

go.bsky.app/JmQksC

The first CryoEM/ET pack is full
I will create a second one if needed.

Hi Lars-Anders, we use BioComp gradient maker and fractionator for virus. If you would like to know more please email me -

Hi is there room for one more?

Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors - Nature Communications This study presents the first high-resolution structure of infectious parvovirus B19, purified from a patient. Two acute phase reactants, serpinA3, and ITIH4, bind to the capsid, suggesting B19V utili...

www.nature.com/articles/s41...

Polio Vaccine Recommendations Find routine recommendations, accelerated schedules, other considerations for polio vaccine.

Polio has been detected in wastewater in NY for some time - so it’s out there and probably elsewhere too. For those of us on the older side who were vaccinated against polio decades ago, the CDC recommends a booster. Check with your healthcare provider to see if you should get one.