Rob Hynds

The multiomics blueprint of the individual with the most extreme lifespan In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

www.cell.com/cell-reports...

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...

Our latest work is available on BioRxiv!

WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.

www.biorxiv.org/content/10.1...

📣Call for Papers!📣

We aim to showcase work that investigates the underlying mechanisms for lung repair in health and disease, including lung development

📆Deadline: December 31, 2025

🔬Learn More Here: tinyurl.com/ye24jb76

🖱️Submit here: tinyurl.com/yahzwj8k

@atscommunity.bsky.social #medsky

Pre-Cancer Immunology The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only

www.ucl.ac.uk/medical-scie...

The AJRCMB Call for Papers on Lung Repair Models and Mechanisms - launched at the Vermont Stem Cell Conference earlier this month - is now open!

Please consider submitting your next paper here.

Thanks to Janette Burgess and Andrew Halayko for making this happen 🙌

It was an honour to co-chair the 20th Anniversary Vermont Lung Stem Cell Conference in Vermont last week. Grateful to Amy Ryan, @skocguen.bsky.social‬ & Dan Weiss, our planning teams, and everyone who joined us. Excited to return to Burlington in 2027!

Great to see Krijn’s work from @crick.ac.uk published! He developed clonal organoid lines from NSCLC tumours and PDX models. Immune evasion varied between clones from the same tumour, highlighting intratumour heterogeneity and providing a model to study it.

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.

Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.

www.science.org/doi/10.1126/...

Had a wonderful time at the @bsgct.bsky.social annual conference!
I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.

Great to see so many familiar faces registered for the 20th Anniversary Stem Cells, Cell Therapies & Bioengineering Conference in Burlington in July.

There’s still time to register and for trainees to book a spot on the unique pre-conference workshops.

t.co/vbsFFhaeAZ

Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a combination of two of the identifie...

This is quite amazing, the team identified some exceptionally powerful neutralizing antivenom antibodies and are working toward a universally protective cocktail.
Brilliant, and all it took was for a single person to get bitten by snakes some 200 times....
www.cell.com/cell/fulltex...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!

We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.

doi.org/10.1242/jcs....

Remembering David Stephens (1971–2024) In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...

A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...

Don't forget to secure your place and submit your abstract for the LSCN 8th Annual Symposium!
🔗Registration: eventbrite.co.uk/e/8th-annual...
Website: lscn.co.uk (where the final agenda will be published soon)
Abstract submission (deadline 04/04!) docs.google.com/forms/d/e/1F...

Scientists aiming to bring back woolly mammoth create woolly mice Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants

It's a start I suppose.
www.theguardian.com/science/2025...

Home - London Stem Cell Network

LSCN Members can access a code for free registration! Become a member by registering on our website lscn.co.uk and find the free code on the symposium page!

Ras inhibition in CAFs reduces their activation and decreases tumor burden.

Awesome new work from collaborator Esther Castellano's team 👏

Happy holidays from everyone in the EpiCENTR group!

Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁

(h/t scholargoggler.com)

This radiotracer can distinguish high/low NRF2 antioxidant pathway activation, including in our TRACERx lung cancer PDX models!

Great to see the manuscript out, congrats Tim and team! 👏

Early bird registration ends 20th Dec - register early!

Early bird registration ends 20th Dec - register early!

We're hiring a postdoc! Please forward to people you know who are looking for positions.
Interested in studying how metabolism is wired to support fertility? 🔬🪰 Come join us!
Ad to go live next week, but informal enquiries encouraged.

Home CancerTools.org is part of Cancer Research UK. Discover a global, non-profit, cancer research tools biorepository

Our TRACERx lung cancer patient-derived-xenograft (PDX) models are now available to the research community at CancerTools.org! 🎉

Huge thanks to Dave Pearce, @charlesswanton.bsky.social and the brilliant CRUK LCCE team who have made this possible.

Find out more here: cancertools.org/nsclc-pdx-mo...

+1 please!

+1 please!

+1 please!

Done - thanks!

Of course - you had both already made it on there! In fact for a long time Andy you were the only person I followed on here! I saw you’d moved over and had planned to do it sooner myself…

go.bsky.app/VC83FZm