Raúl Valderrama

We are the tool's documentation (which no one reads), a YouTube tutorial by an Asian guy (who explains it better than the actual paper), ChatGPT (which sometimes makes things up but keeps my morale high), and my stubbornness, against my expert thesis committee… clearly, it's a fair fight 🫠

A Gentle Introduction To Graph Theory So many things in the world would have never come into existence if there hadn’t been a problem that needed solving. This truth applies to…

medium.com/basecs/a-gen...

RPKM, FPKM and TPM, clearly explained | RNA-Seq Blog from StatQuest It used to be when you did RNA-seq, you reported your results in RPKM (Reads Per Kilobase Million) or FPKM (Fragments Per Kilobase Million). However, TPM (Transcripts Per Kilobase Milli...

www.rna-seqblog.com/rpkm-fpkm-an...

biostatsquid.com/volcano-plot/

Hundreds of cancer papers mention cell lines that don’t seem to exist Finding could be an indicator of paper mill activity

Hundreds of cancer papers mention cell lines that don’t seem to exist | Science | AAAS www.science.org/content/arti...

Subtypes of Breast Cancer Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes. The classification of these subtypes has evolved over the years. The most common and widely accepted classif...

www.ncbi.nlm.nih.gov/books/NBK583...

A guidebook of spatial transcriptomic technologies, data resources and analysis approaches Advances in transcriptomic technologies have deepened our understanding of the cellular gene expression programs of multicellular organisms and provided a theoretical basis for disease diagnosis and t...

🧬 Spatial transcriptomics is revolutionizing biology! It maps gene expression in 3D, revealing how cells interact in tissues.
🦠 From tumor progression to immune responses, this tech unlocks key insights into health and disease. 🚀 #Science #SpatialTranscriptomics

www.csbj.org/article/S200...

China’s cheap, open AI model DeepSeek thrills scientists DeepSeek-R1 performs reasoning tasks at the same level as OpenAI’s o1 — and is open for researchers to examine.

www.nature.com/articles/d41...

Comparing the Most Popular Tools and Pipelines for Bulk RNA-Seq A comprehensive comparison of the most popular tools and pipelines for bulk RNA-seq data

www.elucidata.io/blog/bulk-rn...

Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data - Nature Protocols In this Tutorial Review, Hemberg et al. present an overview of the computational workflow involved in processing single-cell RNA sequencing data.

scRNA-seq analyzes gene expression at the single-cell level, uncovering cellular heterogeneity. It identifies biomarkers, reconstructs cellular trajectories, and enables personalized therapies, revolutionizing precision medicine.

www.nature.com/articles/s41...

More than 40% of postdocs leave academia, study reveals Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers

https://go.nature.com/3Ej9RxA

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences Bidirectional transfer of mitochondria between cancer and immune cells.

The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences

https://go.nature.com/3PNuEfh

A scalable system using mini-organs to test personalized RNA therapy Platform to accelerate the testing of antisense oligonucleotides.

A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases

https://go.nature.com/3POiHpJ