Ester Gea-Mallorquí

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

Headline from an article in Nature this week that states "Prizes must recognize machine contributions to discovery. The future of science will be written by humans and machines together. Awards should reflect that reality."

Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.

Fwd: Fwd: “I hope this email finds you well”

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

Jane Goodall’s legacy: three ways she changed science The primatologist challenged what it meant to be a scientist.

As we mourn Jane Goodall, this @nature.com article explores three ways in which she changed science:

1. Altering the way we view both other primates and ourselves
2. Inspiring generations of women scientists
3. Communicating science in a way that engaged the public

www.nature.com/articles/d41...

One of most beautiful posters in Catalan from the Spanish Civil War. "Peasant!: the revolution needs your efforts." Socialist UGT trade union. By Josep Subirats

Is there a reason I ask that the Times are using a picture of asylum seekers in a boat to describe rules for migrants who came on legal routes such as skilled worker visas for doctors?

Image from the funeral procession of anarchist leader Buenaventura Durruti. At front is Natividad Falú Duval from Puerto Rico who had lived in Barcelona since 1916. In 1936 joined the Durruti Column. POUM aid office Socorrs Roig behind. La Rambla, 22 November 1936. Don't know 📸

A person's genetics has a role in susceptibility to many diseases (Figure), but has little correlation with how the disease may progress or lead to a fatal outcome.
nature.com/articles/s4158

The image is an X post by @RealJakeBroe from 7 hours ago, featuring a two-panel comic. The top panel shows a scientist pointing to a chart with a general trend and an outlier, illustrating a rational argument. The bottom panel depicts a person labeled "ANTI VAX" pointing to a similar chart, labeling it "CONSPIRACY THEORY" with "Lies" and an outlier called "IRREFUTABLE PROOF!!!", satirizing irrational arguments. The caption reads, "It is difficult to win an argument with a smart person. It is impossible to win an argument with an idiot."

This captures much of the frustration of today.

"Two viable female candidates run for president in the last decade and lose to a man who can't make complete sentences. It says more about us as a society. ~ @MrGee54

"Two viable female candidates run for president in the last decade and lose to a man who can't make complete sentences. It says more about us as a society.

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.

www.biorxiv.org/content/10.1...

Labor productivity has more than doubled since the late 1960s. But workers’ compensation has barely budged.

Yes. The economy is rigged in favor of the wealthy.

Roman Barcino, 985 CE superimposed on map of Barcelona in 2022. Note. Barcino was pronounced "Barkino" with a hard K. By Jorge M Corada for @despertaferroed.bsky.social magazine

‘One jab will do the job’: Pakistan begins rollout of HPV vaccine to millions of girls Despite vaccination hesitancy, the end may be in sight for cervical cancer, which kills 64% of women with the disease

‘One jab will do the job’: Pakistan begins rollout of HPV vaccine to millions of girls.

Globally, cervical cancer is the 4th-most common cancer among women, but ranks third in Pakistan, where 64% of cases are fatal.

🧪♀️💉 #medsky
www.theguardian.com/global-devel...

"…and Magda Goebbels made a great strudel.”

RFK Jr does not just reject vaccines. He rejects science and must step down | Bernie Sanders Kennedy is unfit to be our nation’s leading public health official because he rejects the fundamental principles of modern science

For generations doctors have understood that germs — like bacteria or viruses — cause infectious diseases.
 
Yet we now have an HHS Secretary casting doubt on the germ theory — the foundation of modern medicine.

That’s not only unacceptable, it is dangerous. RFK Jr. must resign.

Come visit our Centre for Immuno-Oncology activities at the Old Road Campus Research Building for @ox.ac.uk Open Doors! Learn about the amazing science we do in our department through fun games. Kids will understand antigens and there’s a complicated enigma for the grown ups 🔍👩‍🔬👨‍🔬🧪 #OxfordUOpenDoors

Using biobanks to boost research: a how-to guide From large national databases to bespoke sample collections, biobanks offer a wealth of avenues for scientific enquiry.

From large national databases to bespoke sample collections, biobanks offer a wealth of avenues for scientific enquiry.

go.nature.com/4nlybAb

The 16th Ebola Virus Disease Outbreak in Bulape Health Zone, Kasai, Democratic Republic of the Congo: A new spillover event from an unknown reservoir host Background The Democratic Republic of the Congo (DRC) is currently facing concurrent outbreaks including mpox, cholera and malaria (1-4). The Ministry of Public Health, DRC has declared the 16th Ebola...

Sequence data from the new Ebola outbreak in DRC suggests it is indeed a new spillover.

And just incredible to see the virus sequenced and the data publicly shared less than 24 hours after confirmation of the outbreak.
#IDsky 🧪

virological.org/t/the-16th-e...

One of the main problems of organizational life in higher ed is that there are 12 different places where digital information lives. We've got Teams, Sharepoint, Canvas, MySeaport, OneDrive, DocuSign. Knowing what lives where is a puzzle, and searching for things uses up so much time.

Vaccines are safe and effective. RFK Jr. isn’t.

Be like Pluto.

To restore trust in science, scientists should focus on storytelling Holden Thorp, PhD, top editor at Science, discusses the essential role of front-line doctors, the power of well-told stories, and the value of admitting error.

“What can I do? I can try to help us build a scientific enterprise that won’t be as easy to attack. To do that, we need to do a better job recognizing that the public is investing in this and we owe them a debt of gratitude, rather than simply lecturing to them about all the great things we found”

mRNA vaccines for HIV trigger strong immune response in people Results from early-stage trial show that 80% of participants who received one of two HIV vaccine candidates produced antibodies against viral proteins.

www.nature.com/articles/d41...

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...

Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization - Nature Biomedical Engineering Floss-based vaccination exploits the leaky junctional epithelium of the gingival sulcus to deliver different types of vaccine, inducing robust mucosal and systemic immunity and providing protection ag...

Dental floss as a #vaccination strategy? This study shows that floss-based vaccination can deliver protein, inactivated virus, peptide-presenting immunogenic nanoparticles, mRNA & induces #immuneresponses protecting against infectious disease in mice ➡️ www.nature.com/articles/s41... #immunity