Ester Gea-Mallorquí

Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides @natimmunol.nature.com
www.nature.com/articles/s41...

Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring
A new review of the evidence just out
www.thelancet.com/journals/lan...

"It's my turn to use the microscope"

Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access
rupress.org/jem/article/...

it's more of a comment than a ques

Great discussion - patient groups are central to A/I partnerships -especially in the ED/prevention space….

BLOG: Patient and Public Involvement in Research Are you interested in public engagement with cancer research? Julliet Lwiindi, Oxford Cancer's Public Engagement and Involvement Officer, shares a little about the ways in which you can engage with ou...

Are you interested in Patient and Public Involvement (PPI) in research?

Julliet Lwiindi, Oxford Cancer's PPI Officer, shares a little about how Cancer Researchers at the University of Oxford can engage with our PPI group 👇

www.cancer.ox.ac.uk/news/blog-pa...

Tim Elliott @timmunologist.bsky.social chairs today's panel discussion at #OXCODE25!

The panel consider: 'Are industry/academia partnerships essential for advancing early detection and prevention research for patient benefit?'

#OxfordCancer #Prevention #EarlyDetection

Backlash Hits Pantone After Color Of The Year Slammed As 'Tone Deaf,' 'Dystopian’ Pantone says the color is calming and relaxing. Critics say it's a reflection of the current political climate.

Pantone says the color is calming and relaxing. Critics say it's a reflection of the current political climate.

Order in which cancer-driving mutations occur affects the chance of tumour development Randomly acquired mutations face strong negative selection, except on certain cancer-promoting backgrounds.

What happens to the thousands of intestinal cells that have tumour-initiating DNA mutations?

go.nature.com/4rBbOtq

Study suggests up to 1 in 4 breast cancers happen before 50 - UPI.com As many as 1 in 4 breast cancers occur in women younger than 50, researchers said at the Radiological Society of North America's annual meeting.

Women younger than 50 consistently accounted for 1 in every 4 breast cancers detected. The data also showed that younger women not only carry a stable and substantial share of the breast cancer burden, but their tumors are often biologically aggressive. #RSNA25
www.upi.com/Health_News/...

photo of someone walking a dog in a park on a winter's day, with the sun low in the sky behind bare trees in an urban setting.

Only 3 weeks until the days start getting longer again ⛅

Hang in there, SAD people ❤️

Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.

Remarkable story of a Georgia high school team who used CRISPR to make a rapid diagnostic test strip for Lyme disease, speeding dx from 2 weeks to days
www.cbsnews.com/news/teens-m...

Huge respect to the papers for finding both an 88 year old worried about the tax bill on her 6 bedroom Kensington house and a 20 year old fretting about only being able to save £12k a year tax free.
Top work all around. These are not easy case studies to find.

Pope stands holding a baseball bat on a plane

Finally getting some theological clarity on the ethics of reclining in one’s plane seat

Mechanism for selection and inhibition of an HIV-1 escape virus by T cells and NK cells (TCR- and KIR2DL2-HLA-C*12:02-peptide complexes)
www.nature.com/articles/s41...
@natcomms.nature.com @hokkaidouniv.bsky.social @ox.ac.uk

How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role Remains of some of the 300,000 soldiers who died on the retreat from Moscow reveal two bacterial diseases that probably added to the death count.

Some disease-ridden French soldiers have just received a new diagnosis — although it comes about two centuries too late

go.nature.com/4obJzzy

Una terapia experimental salva la vida de más de medio centenar de niños con una enfermedad letal El tratamiento, que se administra una sola vez y listo, ha permitido que la niña Eliana Nachem, encerrada en su casa para evitar infecciones, salga al mundo

Y hoy, en Viva la ciencia:

Una terapia experimental salva la vida de más de medio centenar de niños con una enfermedad letal
elpais.com/ciencia/2025...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

Headline from an article in Nature this week that states "Prizes must recognize machine contributions to discovery. The future of science will be written by humans and machines together. Awards should reflect that reality."

Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.

Fwd: Fwd: “I hope this email finds you well”

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

Jane Goodall’s legacy: three ways she changed science The primatologist challenged what it meant to be a scientist.

As we mourn Jane Goodall, this @nature.com article explores three ways in which she changed science:

1. Altering the way we view both other primates and ourselves
2. Inspiring generations of women scientists
3. Communicating science in a way that engaged the public

www.nature.com/articles/d41...

One of most beautiful posters in Catalan from the Spanish Civil War. "Peasant!: the revolution needs your efforts." Socialist UGT trade union. By Josep Subirats

Is there a reason I ask that the Times are using a picture of asylum seekers in a boat to describe rules for migrants who came on legal routes such as skilled worker visas for doctors?

Image from the funeral procession of anarchist leader Buenaventura Durruti. At front is Natividad Falú Duval from Puerto Rico who had lived in Barcelona since 1916. In 1936 joined the Durruti Column. POUM aid office Socorrs Roig behind. La Rambla, 22 November 1936. Don't know 📸

A person's genetics has a role in susceptibility to many diseases (Figure), but has little correlation with how the disease may progress or lead to a fatal outcome.
nature.com/articles/s4158

The image is an X post by @RealJakeBroe from 7 hours ago, featuring a two-panel comic. The top panel shows a scientist pointing to a chart with a general trend and an outlier, illustrating a rational argument. The bottom panel depicts a person labeled "ANTI VAX" pointing to a similar chart, labeling it "CONSPIRACY THEORY" with "Lies" and an outlier called "IRREFUTABLE PROOF!!!", satirizing irrational arguments. The caption reads, "It is difficult to win an argument with a smart person. It is impossible to win an argument with an idiot."

This captures much of the frustration of today.

"Two viable female candidates run for president in the last decade and lose to a man who can't make complete sentences. It says more about us as a society. ~ @MrGee54

"Two viable female candidates run for president in the last decade and lose to a man who can't make complete sentences. It says more about us as a society.