Pablo Laborda

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5
@pablolaborda.bsky.social

How we can fight AMR

imili.org/new_gallerie...

@sbigot.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6
@pablolaborda.bsky.social, @crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social

How we can fight AMR

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9
@pablolaborda.bsky.social
@crisherencias.bsky.social

How it works

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2
@pablolaborda.bsky.social

imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1
@pablolaborda.bsky.social
imili.org/pdf/Antimicr...

New preprint out! 📣🚨

We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠

#Microsky

We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?

In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!

👇 Check out all the details in Paula’s thread!

Hint: 🐇 (most of the time)

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉

🧵 (1/14)

www.doi.org/10.1038/s414...

Universal rules govern plasmid copy number - Nature Communications Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...

Enhorabuena Alberto!! 💪

Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT

Aquí os cuentan mis compañeras Susana de Lucas y Jennifer Palencia, de Comunicación y Cultura Científica del @cnb-csic.bsky.social, nuestro último trabajo. Describimos una estrategia de base evolutiva para eliminar la resistencia a ciprofloxacino en aislados clínicos de P. aeruginosa. Felices! 🤩

Check out this cool collaboration with @hernando-amado.bsky.social, just out in @natcomms.nature.com!
We show that ciprofloxacin resistance rapidly declines in clinical P. aeruginosa strains under drug-free conditions, suggesting that ciprofloxacin restriction periods could help in clinics 🦠🧫

Enhorabuena Sara!! 🚀🚀

Ceftazidime-avibactam use selects multidrug-resistance and prevents designing collateral sensitivity-based therapies against Pseudomonas aeruginosa - Nature Communications Ceftazidime-avibactam is a β-lactam/β-lactamase inhibitor combination restricted for the treatment of multidrug-resistant infections of Pseudomonas aeruginosa non-susceptible to ceftazidime and resist...

Ceftazidime-avibactam (a last resort drug) use selects multidrug-resistance and prevents designing collateral sensitivity based therapies against P. aeruginosa (no robust patterns emerge). Happy to see it published! 🥳 @cnb-csic.bsky.social @idisba.bsky.social
www.nature.com/articles/s41...

Are you a #Pseudomonas researcher? Please take our survey and help shape the direction and priority of future pseudomonas.com database development: forms.gle/gTPT6ruf3mqb...
#microsky #idsky

Last month, I had the chance to share my research in my hometown – more than 7 years since I did my bachelor’s degree over there!
Today, the local newspaper @heraldo.es features some insights from the event participants about their research (and life) abroad
www.heraldo.es/noticias/ara...

Our group is looking for a PostDoc with a strong background in molecular microbiology, strain design and genetic engineering. Join us at DTU to work on bacterial infections and antimicrobial resistance!
www.rigshospitalet.dk/job-og-uddan...

Truly well deserved!! Congrats again, Jero!

⚠️ Job(s) alert! ⚠️

We are launching a new postdoctoral program in Systems Biology at IBFG. Join us!

👉 Several positions available with competitive work conditions for up to 4 years

📄 More info: jdiazc9.github.io/files/jobs/2...

📣 Postdoc Position open in our lab m in Madrid.

If you are motivated with AMR transmission using Genomics and Metagenomics for the next 3 years send your cv and a motivation letter to aru@ucm.es

#OneHealth

@ucm.es @escmid.bsky.social

Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms - npj Biofilms and Microbiomes npj Biofilms and Microbiomes - Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms

Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms

-in NPJ Biofilms and Microbiomes from Andrea M. Smania (Argentina)

www.nature.com/articles/s41...