Harry Fu

Happy holidays from the Fu lab! Wish you and your loved ones have a wonderful holiday season!

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo
alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Thanks, Sarah! So happy to chat with you at AAIC! Looking forward to seeing you again next year.

Thank you #AAIC2025 for your great support for our talented young scientists who are interested in Alzheimer’s disease. Congratulations on all Poster competition winners, including my fantastic PhD student, Tae Yeon Kim. So proud of you!!!

Human 'mini-brains' reveal protein GRAMD1B's potential role in neurodegeneration Researchers at The Ohio State University Wexner Medical Center and College of Medicine have discovered a new way that neurons act in neurodegeneration by using human neural organoids—also known as "mini-brain" models—from patients with frontotemporal lobar degeneration (FTLD).

Human neural organoids suggest the protein GRAMD1B may influence cholesterol and lipid management in neurons, potentially impacting treatments for neurodegenerative diseases like FTLD and Alzheimer's. doi.org/g9dwst

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau - Nature Communications The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, an...

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
www.nature.com/articles/s41...

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau - Nature Communications The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, an...

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau www.nature.com/articles/s41...

Happy holidays from the Fu lab! Wish you and your loved ones have a wonderful holiday season!

Congratulations, Lea! Well deserved!

Implementation and validation of single-cell genomics experiments in neuroscience - Nature Neuroscience Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance o...

Implementation and validation of single-cell genomics experiments in neuroscience - a consensus paper.

Excited to contribute perturbation-based approaches.

www.nature.com/articles/s41...