Charles Ishak's Avatar

Charles Ishak

@cishak.bsky.social

Assistant Professor at UT MD Anderson Cancer Center. Our lab studies transposable elements and viral mimicry in (ovarian) #cancer initiation. #newPI Lab site: https://www.mdanderson.org/research/departments-labs-institutes/labs/ishak-laboratory.html

1,597 Followers  |  391 Following  |  20 Posts  |  Joined: 29.08.2023  |  2.3444

Latest posts by cishak.bsky.social on Bluesky

Congratulations Josh!

20.07.2025 11:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Van Andel Institute appoints cancer epigenetics expert Dr. H. Josh Jang as assistant professor – Van Andel Institute Read about Van Andel Institute appoints cancer epigenetics expert Dr. H. Josh Jang as assistant professor on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in...

Congratulations to VAI's Dr. H. Josh Jang, who has been appointed to assistant professor in our Department of Cell Biology.
www.vai.org/article/van-...

01.07.2025 19:41 β€” πŸ‘ 13    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Sharon Dent inducted to the National Academy of Sciences #nas162 @ekoutelou.bsky.social @srdent47.bsky.social @angelating.bsky.social @francescacole.bsky.social

25.04.2025 23:26 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Dear @mdanderson.bsky.social ,

Please join us today in auditorium 4SCR1.1110 at 4pm for our Dept. seminar series. Today we welcome Dr. Marco Gallo from Baylor College of Medicine who will share the latest breakthroughs towards understanding chromatin regulation in brain malignancies.

15.05.2025 15:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome...

Check out Dr. Mendez-Dorantes' recent preprint for more details on his exciting research! www.biorxiv.org/content/10.1... 42/

09.05.2025 14:41 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Looking forward to #AACR25! If you want to learn more about transposable elements in cancer, our educational session is at 10 am on Saturday 4/26!
@bengrbm.bsky.social @theaacr.bsky.social

25.04.2025 10:52 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1
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Could blocking β€˜jumping genes’ help fight disease and aging? The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

Such a great article by Mitch Leslie in @science.org about the potential of inhibiting LINE-1 RT – a genomic, virus-like repetitive element – to address a spectrum of diseases, including ROME’s focus: #neurodegenerative and #autoimmune diseases. www.science.org/content/arti...
#darkgenome

18.04.2025 17:24 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

Thank you for your support @completegenomics.bsky.social !

15.04.2025 19:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Complete Genomics Names Four Winners of Spatial Xcellerator Grant Program - Complete Genomics SAN JOSE, Calif., April 15, 2025 – Complete Genomics, a leading innovator in genomic sequencing, today announced four winners from 30 applicants to its Spatial Xcellerator Grant Program. Winning proje...

Congrats to the 4 winners of our Spatial Xcellerator Grant Program who are using Stereo-seq technology for spatial transcriptomics to uncover deeper insights into complex challenges like cancer, spinal cord injury, Alzheimer’s, and pediatric brain tumors.

www.completegenomics.com/spatial-xcel...

15.04.2025 16:29 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Meet Dr. Daniel De Carvalho: viral mimicry response, cancer detection and interception
YouTube video by UHN Research Meet Dr. Daniel De Carvalho: viral mimicry response, cancer detection and interception

πŸŒŸβ€œSurprise is always the strongest signal that you found something new.”

Research from Gairdner awardee @daniel-decarvalho.bsky.social is unlocking powerful new tools impacting cancer clinical care, from interception, detection to therapy design and monitoring.

youtu.be/VpDpouQi8Wg

11.04.2025 15:38 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Congratulations to my postdoctoral mentor Dr. @daniel-decarvalho.bsky.social on receiving the 2025 Gairdner Momentum Award from the @gairdnerawards.bsky.social ! This is an amazing achievement!

11.04.2025 14:09 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Canadian scientist wins Breakthrough Prize for discovery of hormone used in Ozempic, Mounjaro A Canadian researcher has won a 2025 Breakthrough Prize in Life Sciences for discovering the GLP-1 hormone used in diabetes and obesity medications β€” including Ozempic, Wegovy and Mounjaro β€” that have...

Down to earth (as always) interview with @danieljdrucker.bsky.social on the impact of GLP1 agonists in fields of biology that he’d never anticipated but is leading the way on understanding - as awardee of th3 Breakthrough Prize with colleagues. www.ctvnews.ca/sci-tech/art...

06.04.2025 01:53 β€” πŸ‘ 76    πŸ” 16    πŸ’¬ 3    πŸ“Œ 0
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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...

Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...

27.03.2025 14:29 β€” πŸ‘ 17    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
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Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025 Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025

exciting news for our scientific community! www.nygenome.org/news-events/...

27.03.2025 19:26 β€” πŸ‘ 65    πŸ” 10    πŸ’¬ 4    πŸ“Œ 0

So happy to join the dream dean team at the UT MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences!

21.03.2025 23:16 β€” πŸ‘ 30    πŸ” 3    πŸ’¬ 7    πŸ“Œ 0
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Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells - Nature Protocols Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) uses an amphiphilic peptide reagent to mediate intracellular delivery of CRISPR enzymes for high-efficiency editing of stimulat...

I'm proud to share our protocol on CRISPR enzyme delivery in primary human cells using PERC, a non-viral & hardware-independent technology. We previously described PERC in T cells, and here we extend its use to hematopoietic stem/progenitor cells (HSPCs).
www.nature.com/articles/s41...

19.03.2025 08:14 β€” πŸ‘ 12    πŸ” 5    πŸ’¬ 4    πŸ“Œ 0
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New Links: Cancer and Immune Evasion

Cancer cells without the tumor suppressor protein p53 become more resistant to the body's immune response and more likely to survive. A study led by Dr. Daniel De Carvalho at UHN’s Princess Margaret Cancer Centre.

www.uhnresearch.ca/news/new-lin...

17.03.2025 17:09 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

@uhnresearch.bsky.social @uhntoronto.bsky.social @theaacr.bsky.social

17.03.2025 17:09 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!

24.01.2025 06:19 β€” πŸ‘ 15    πŸ” 8    πŸ’¬ 0    πŸ“Œ 2

Dear @mdanderson.bsky.social community,
We are excited to invite you to our dept. seminar featuring Dr. Katherine Chiappinelli (@chiappinellilab.bsky.social) tomorrow (Thursday March 6) at 4:00pm in auditorium room 4SCR1.1110.

Drop by to learn about TEs as therapeutic targets in (ovarian) cancer!

06.03.2025 02:26 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Happy to see this paper out!

25.02.2025 16:16 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Scientists @pmresearch-uhn.bsky.social have uncovered how cancer can evade immune defenses after losing a key tumour-suppressing gene. These findings implicate repetitive elements in DNA and may unlock new targets for cancer interception.

Read more ➑️ www.uhnresearch.ca/news/new-lin...

25.02.2025 16:11 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1

When I opened my Bsky account I didn't expect my first post to be an act of resistance, but here we are!!! So proud of our Chair for speaking out to our Texas Representative about the chaos that the #NIHfreeze is causing throughout the US! #sciencematters #researchmatters #endcancer

27.01.2025 00:52 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
Photo of a group of scientists at the building entrance of Johns Hopkins school of medicine and in a conference room. The left photo is a picture of a scientist sitting at his former postdoc research bench

Photo of a group of scientists at the building entrance of Johns Hopkins school of medicine and in a conference room. The left photo is a picture of a scientist sitting at his former postdoc research bench

I returned to Johns Hopkins for a seminar, reunited with colleagues and luminaries in the field, and sat at my postdoc bench once more. πŸ§ͺ

#HopkinsMedicine #JHU #CancerResearch #Epigenetics

25.01.2025 14:51 β€” πŸ‘ 84    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

Thank you to @daniel-decarvalho.bsky.social and all members of the team who made this study possible! This study represents an exciting new direction towards understanding how dsRNAs contribute towards tumorigenesis and considering new ways to exploit viral mimicry!

17.01.2025 15:24 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...

07.01.2025 16:26 β€” πŸ‘ 22    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Hello #cancersky! It's official, we're here! Follow us for all things #cancerresearch and #oncology πŸ₯³

19.12.2024 09:07 β€” πŸ‘ 44    πŸ” 8    πŸ’¬ 2    πŸ“Œ 0
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Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) πŸ‘‡πŸ§΅ #TESky πŸ§ͺ

12.12.2024 18:56 β€” πŸ‘ 154    πŸ” 74    πŸ’¬ 12    πŸ“Œ 7

Congrats! Very interesting system to discover regulators of endogenous dsRNA.

06.12.2024 01:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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What better place than the city of lights to make my transposition to πŸ¦‹. Look at all that blue sky!

04.12.2024 17:08 β€” πŸ‘ 87    πŸ” 11    πŸ’¬ 6    πŸ“Œ 3

@cishak is following 20 prominent accounts