David Smadja 🎗️

Dexamethasone Suppresses Endotheliopathy and Endothelial-Induced Coagulopathy in COVID-19 | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Endotheliopathy and coagulopathy are known complications of COVID-19, with a significant association with mortality. Although dexamethasone is the standard of care for patients with severe...

🚨 New paper from the lab in ATVB

Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸

@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr

www.ahajournals.org/doi/10.1161/...

Maladie thromboembolique veineuse : prédire le risque de récidive grâce à la génétique - Salle de presse de l'Inserm Troisième cause de mortalité cardiovasculaire, la maladie thromboembolique veineuse résulte de la formation d’un caillot pouvant bloquer la circulation sanguine dans une veine et provoquer des complic...

Maladie thromboembolique veineuse : prédire le risque de récidive grâce à la génétique

Lire le communiqué : presse.inserm.fr/maladie-thro...

Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study AbstractBackground and Aims. Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through develo

PARCC Highlight:
New research from Pr Rosa Maria Bruno @PARCC INSERM and Université Paris Cité, published in the European Heart Journal, reveals that COVID-19 can accelerate vascular aging, especially in women. doi.org/10.1093/eurh...

Left ventricle strain and T1 mapping evaluation in a mouse model with myocardial infarction - Scientific Reports Scientific Reports - Left ventricle strain and T1 mapping evaluation in a mouse model with myocardial infarction

B Tavitian team and coworkers @PARCC used MRI to evaluate myocardial strain and T1 mapping in mice. This methodological approach not only refines imaging sequences but also offers insights into cardiac function and tissue characteristics. www.nature.com/articles/s41...

sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial - Scientific Reports Scientific Reports - sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial

David Smadja and co-workers @PARCC found that the biomarker sST2 independently predict clinical outcomes in hospitalized COVID-19 patients.
www.nature.com/articles/s41...

Pathology-oriented multiplexing enables integrative disease mapping Nature - Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high...

O. Lenoir, P.L. Tharaux and co-workers @PARCC have developed PathoPlex, a powerful new framework for multiplexed tissue imaging. This scalable tool maps over 140 proteins at subcellular resolution, helping to uncover key disease mechanisms in kidney health and disease.
rdcu.be/eCs2P

Safety of venetoclax in real-world experience: data from the French national database of pharmacovigilance through all indications in hematological malignancies over 5 years - Alexis Talbot, Pierre-Ed... Background: Venetoclax is the first representative of a new class of targeted therapy, that inhibits selectively B-cell lymphoma-2 (BCL-2), an anti-apoptotic pr...

🎉Last paper from the team 📰
Retrospective study of all cases of adverse events (AEs) under #venetoclax recorded in the French pharmacovigilance database 🇫🇷 since its market approval.
➡️ 36% AEs were not listed in the SPC including autoimmune hemolytic anemias (2%) 🩸 or cardiac (7%) ❤️‍🩹

Entretien dans Marianne : pourquoi la désinformation en santé est un enjeu démocratique.
🎯 Notre objectif : faire de la santé un bien démocratique, fondé sur la confiance, la transparence et le partage du savoir. Il ne s’agit pas de censurer, mais de reconstruire un socle commun de compréhension.

sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial This protocol is based on the protocol produced by the National Institute of Health for the World Health Organization (WHO), version of 03/03/2020, which further led to the Solidarity protocol of WHO. This study supports the integration of the Solidarity...

sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial
->Nature | #Covid19 | More info from EcoSearch

sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial - Scientific Reports Scientific Reports - sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial

🧬 🔬 Notre nouveau papier dans Scientific Reports identifie le biomarqueur sST2 comme biomarqueur pour prédire l’évolution clinique COVID-19 dans l’essai #DisCoVeRy 🇪🇺

📖 doi.org/10.1038/s415...

#COVID19 #EUResponse #endotheliopthy #ST2

🔎 How can we fight a pandemic when misinformation spreads faster than the virus itself?

📍 Next week, I’ll have the pleasure of speaking at the University of Toronto 

🎤 I’ll be sharing my reflections on the topic:
"From Viral Outbreak to Infodemic: The Dual Pandemics of COVID-19"

@acc2025.bsky.social @jaccjournals.bsky.social

The article published in the @NEJM.org can be accessed.see below

Citation:
Mahé I, Carrier M, Didier M, et al. Extended reduced-dose apixaban for cancer-associated venous thromboembolism. NEJM. Published online March 29, 2025. Doi: 10.1056/NEJMoa2416112

🩸 Thrombose & embolie pulmonaire : Bravo @gendronn.bsky.social : les CD34⁺ pourraient prédire séquelles post-EP. Un pas de plus —> meilleure compréhension de la recanalisation du thrombus @upcite.bsky.social @hopitalpompidou.bsky.social

📄 link.springer.com/article/10.1...

A Highway for Disinformation? The Alarming Exodus of Scientists from Twitter/X and its Consequences - Stem Cell Reviews and Reports Stem Cell Reviews and Reports -

🚨 Les scientifiques quittent Twitter/X, laissant le terrain aux complotistes. Faut-il fuir ou riposter ?

🔗 Lire notre analyse rédigée avec le professeur @nsonnac.bsky.social

@hopitalpompidou.bsky.social
@upcite.bsky.social

link.springer.com/article/10.1...

Poste AHU en Pharmacovigilance/Hématologie
La Faculté de Pharmacie de Paris et l'HEGP-PARCC recrutent un AHU en pharmacovigilance et hématologie à partir de novembre 2025.
📩 Contactez le Pr David Smadja : david.smadja@aphp.fr

🔁 RT bienvenus !
#Pharmacovigilance #AHU
@hopitalpompidou.bsky.social

🚨 Nouvelle revue de notre équipe publiée dans Angiogenesis et ses nouvelles perspectives en médecine régénérative en image 👇🩸🧪✅

link.springer.com/article/10.1...

The #VTE risk associated with #JAKi in #inflammatory diseases has been suggested, followed by precautionary measures by health authorities. This literature review illustrates that available data on VTE risk on JAKi are conflicting and inconclusive
@DavidMSmadja @RPTHjournal
doi.org/10.1016/j.rp...

Regulatory agencies have issued warnings about JAK inhibitors and VTE risk—but what does the evidence actually say?

Our latest review breaks down the data, limitations, and next steps.
@davidmsmadja.bsky.social @isabellemahe.bsky.social

📑 Read now: buff.ly/4ijJQNq

VITT-like Monoclonal Gammopathy of Thrombotic Significance | NEJM Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is associated with antibodies that target platelet factor 4 (PF4) and are heparin-independent. VITT antibodies are implicated in acute,...

Very happy to be part of this international collaboration 🇨🇦🇫🇷🇪🇸🇳🇿🇩🇪 defining the VITT-like Monoclonal Gammopathy of Thrombotic Significance @nejm.org

@hopitalpompidou.bsky.social
@hopitalcochin.bsky.social
@upcite.bsky.social

www.nejm.org/doi/full/10....

#VITT #AntiPF4 #Thrombosis

YouTube video by AP-HP, Assistance Publique - Hôpitaux de Paris Laboratoire de biologie médicale : une chaîne entièrement robotisée au service des patients à l'HEGP

Découvrez en vidéo la nouvelle chaîne robotisée de biologie de l'Hôpital européen Georges-Pompidou @ap-hp.bsky.social !
Un espace entièrement modernisé avec une plateforme automatisée regroupant de nombreuses innovations en robotique.

👉 youtu.be/M8BaWTES0H8

🥳 New findings from our group on anti-PF4/H antibodies during #COVID19 and post #vaccination ! #HIT #VITT @rpth.bsky.social 📰

🔗 www.rpthjournal.org/article/S247...

@davidmsmadja.bsky.social @terrierben.bsky.social
@upcite.bsky.social @hopitalpompidou.bsky.social

@lesechosfr.bsky.social parlent de notre projet de peau artificielle pre-vascularisée ⭐️⭐️⭐️ #pepr #inserm

www.lesechos.fr/idees-debats...

Très forte mortalité due à la grippe cette année, le pic national pas encore atteint

La grippe, une maladie mortelle surtout après 65 ans.

L'année dernière 54% des plus de 65 ans se sont fait vacciner.

3 000 vies supplémentaires pourraient être sauvées si la couverture vaccinale était supérieure à 75 % après 65 ans (seuil fixé par l’OMS).

source : www.ameli.fr/paris/medeci...

The heightened risk of autoimmune diseases after Covid Facts, data, and analytics about biomedical matters.

On the heightened risk of autoimmune diseases after Covid erictopol.substack.com/p/the-height...

Blood DNA virome associates with autoimmune diseases and COVID-19 - Nature Genetics Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic ...

There is an increased risk of autoimmune diseases after Covid, and 2 constituents of the virome (anellovirus and HHV-6) may help to explain this link
nature.com/articles/s41...
a study of 5 different autoimmune diseases in over 6,300 Japanese individuals

Comment restaurer la confiance dans la santé publique ?
Note rédigée avec Nathalie Sonnac.
✅ Former enseignants & parents à l’éducation aux médias
✅ Intégrer des experts scientifiques dans les médias
✅ Renforcer la formation des journalistes lelaboratoiredelarepublique.fr/publications/s…

Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19 - Angiogenesis Angiogenesis -

Nous montrons dans ce dernier travail une augmentation des cellules endothéliales circulantes associée à la fatigue persistante chez les patients COVID long. Avançons pour mieux comprendre: il n'y a pas un COVID long mais des #COVIDLong @hopitalpompidou.bsky.social
link.springer.com/article/10.1...

Face au Scandale de l'IHU la Nécessité de Réformes Profondes et d’Actions Décisives
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Nous invitons les chercheurs choqués par ce qu'ils lisent dans notre lettre ouverte (des années de scandales éthiques et potentiellement criminels) à la signer ici : tinyurl.com/amu-scandal

Controversial COVID study that promoted unproven treatment retracted after four-year saga Paper on hydroxychloroquine led by French researcher Didier Raoult is second-most-cited study ever to be withdrawn.

Toujours plus fort l'article rétracté Gautret a le droit à un article dans Nature

Notre article @damienbarraudmd.bsky.social @therapies.bsky.social cité en référence

@univ-amu.fr @sfpt-fr.org