t(8;14) IGH-MYC. Rarely 2;8 or 8;22

Poll question for haematologists

Is there still a role for Activated Protein C Resistance testing in the assessment for thrombophilia, when FVL PCR is readily available?

1️⃣ YES
2️⃣ NO

Reply with number below.

#hemesky

Splenic marginal zone lymphoma

Practical guideline for major hereditary thrombophilia

www.sciencedirect.com/science/arti...

I came across this “practical guideline” for major heritable thrombophilia. I am not sure I agree with some of their recommendations - should generate an interesting debate though. Also have never tested for the F2 AT resistance mutations!

#hemesky

Plasmodium falciparurm

Combined HbC trait and G6PD deficiency!

Biology resists simplicity #ISTH2025 plenary session

Personal highlights from day 2 of #ISTH2025 👇

Personal highlights from day 1 of #ISTH2025 👇

Babesiosis - the insert shows a Maltese Cross

Giant pronormoblasts seen in parvovirus B19

Prothrombin Complex Concentrate vs Frozen Plasma in Cardiac Surgery This clinical trial compares the efficacy and safety of prothrombin complex concentrate with frozen plasma in patients requiring coagulation factor replacement for bleeding during cardiac surgery.

I think this drug will settle many an argument ….

jamanetwork.com/journals/jam...

Population-Scale Studies of Protein S Abnormalities and Thrombosis This cross-sectional study evaluates the risk associated with protein S deficiency across multiple arterial thrombosis phenotypes in population-level cohorts.

Fascinating paper; which reinforces my own clinical experience that the majority of clinically encountered type I protein S deficiency behave like a low risk thrombophilia, presumably as they have the missense variant. We need more studies like this!

jamanetwork.com/journals/jam...

Delighted to present our survey results on the management of superficial thrombophlebitis in the short saphenous vein when in close proximity to the saphenopopliteal junction at ISTH congress June 21-25, 2025.

If you’re there, come and check out our poster.

@isth.org #Hemesky

Hematology Breakthrough | Displaycia | Global Journal of Medical and Health Sciences Research (GJMHSR)

📢 Hematology Breakthrough! 🧑‍⚕️🔬

📌 Follow us for more updates: @displaycia.bsky.social

🔗 Read more: displaycia.com/medic...

#Hematology #HealthScience #Breakthrough #MedicalScience #ManuscriptSubmission #ScientificResearch #Innovation #Displaycia

Bottom line - the LLN for Ferritin in both women and men should be at least 30 in the absence of inflammation and chronic kidney disease.

Interstitial infiltration with monomorphic medium mature lymphocytes. Starry sky appearance would favour Burkitt but is not specific.

FARES-II: Much anticipated randomized trial @jama.com comparing Plasma to PCC in cardiac surgery (n=420)

Those in PCC arm had ↑ hemostatic efficacy and ↓ RBC transfusion

Hopefully practice-changing for many!

jamanetwork.com/journals/jam...

#transfusion #hemesky

@nejm.org

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism | NEJM In patients with active cancer and venous thromboembolism, whether extended treatment with a reduced dose of an oral anticoagulant is effective in preventing recurrent thromboembolic events and dec...

Finally! More data to add to the EVE trial

APICAT showed non inferiority of apixaban 2.5BD in patients with CAVTE who have completed 6m anticoagulation to 5BD in terms of VTE recurrence (2.1% v 2.8%) and lower clinically relevant bleeding (12.1% v 15.6%)

#Hemesky #BSH

www.nejm.org/doi/full/10....

A Hematopathologist’s Approach to Atypical Lymphocytosis A 23-year-old presented to the emergency room with a headache and a fever of 101.5 degrees Fahrenheit. Physical examination revealed a fatigued patient wit

doi.org/10.1182/hem....

This is a fantastic read. Strongly recommended. #Hemesky

Spherocytes lacking central pallor. Differential diagnosis warm autoimmune haemolytic anaemia, haemolytic transfusion reactions and hereditary spherocytosis

New in The Journal of Haemophilia Practice: a paper reporting on the hopes and goals of a group of men with #haemophilia B, including how new treatments, such as #genetherapy, could help support and redefine their aspirations. Open access here: loom.ly/vJmE2Wg

#HemeSky #BloodSky #MedSky

RPTH Cares about Women's Health 🌸: NAID and IDA are extremely prevalent among women, largely due to iron losses from vaginal blood loss.
Explore the findings: www.rpthjournal.org/article/S247...
@isth.org
#IronDeficiency #WomensHealth

#ASHWomenWednesday ♀️🩸: Learn about why hematologists should care about heavy periods, and test your knowledge with a quick quiz.

Share your insights in the comments!

#ASHEducation #ASHWomenWednesday #WomenInHeme #Shematology #BloodSisters #HemeHeroines #BloodEducation #Microlearning #Hematology

I think you mean ECHELON-3.

CD30 expression is presumably a pre-requisite and it’s not common (I think only 20% of so of DLBCL have it, more common in PMBCL and plasmablastic lymphoma)

Glofit would be a better option but I suppose if you’re refractory to that, and lonc would be another option.

Bite and Blister cells consistent with oxidative haemolysis - usually due to G6PD deficiency.

Funny things patients say in clinic - part 1

“I don’t like those compression stockings for my post thrombotic syndrome. They’re tight” 🧐🧐🧐
#Hemesky

2) At least a theoretical risk of hyperviscosity (both IV immunoglobulins, so giving them together can make your blood too thick, leading to headaches, blurry vision, trouble breathing and risk of blood clots)

If you need both, they are usually given sequentially. ie one after the other.