Sophia Goladze

Gammelt virus gir nytt håp mot resistente bakterier | UiT En bakteriofag fra 1920-tallet viser seg å kunne angripe en bakterie som første gang ble funnet av UiT-forskere hundre år senere. Funnet kan bety nye behandlingsmuligheter i møte med økende antibiotik...

uit.no/nyheter/arti...

From the Marine Bioprospecting group of the @cansuit.bsky.social @uitnorgesarktiske.bsky.social

28.10.2025 09:50 — 👍 4    🔁 2    💬 0    📌 0

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...

06.10.2025 06:27 — 👍 96    🔁 46    💬 3    📌 1

Cell Press logo in shades of blue and white, with a compass superimposed in the background. Title reads: "Ten essential tips to ensure the integrity of your research"

Ensuring the integrity of your research is vital for credibility and impact. Discover ten essential tips to uphold ethical standards and trustworthiness in your work.

Learn more: www.elsevier.com/connect/ten-...

#ResearchEthics #ResearchIntegrity #AcademicResearch

22.09.2025 19:00 — 👍 2    🔁 1    💬 0    📌 0

📝New preprint!

We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.

A short thread 🧶

07.08.2025 12:19 — 👍 27    🔁 11    💬 2    📌 1

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

28.07.2025 19:43 — 👍 111    🔁 48    💬 10    📌 5

22.- Expert opinion on phage therapy: round table from the First International Symposium on Advances in Phage Therapeutics PhageCast · Episode

open.spotify.com/episode/2LD5...

19.07.2025 19:15 — 👍 0    🔁 0    💬 0    📌 0

Commercial porcine gastric mucin contributes to variation in production of small molecule virulence factors by Pseudomonas aeruginosa when cultured in different formulations of artificial sputum mediu... Site-specific in vitro culture media are being developed to investigate microbial pathogenicity and ecology in nutrient environments that are more reflective of disease. For microbial ecology research...

Importance of mucin O-glycans in regularing bacterial metabolism and virulence 🦠🧫
www.biorxiv.org/content/10.1...

16.07.2025 22:12 — 👍 2    🔁 0    💬 0    📌 0

Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes Abstract. Specific human gut microbes inhabit the outer mucus layer of the gastrointestinal tract. Certain residents of this niche can degrade the large an

📚 I am happy to share that our latest paper is out in Glycobiology!

🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.

🔬 We studied its enzymes and ecological interactions in vitro.

#glycotime #mucin #microbiome

academic.oup.com/glycob/artic...

11.12.2024 13:34 — 👍 87    🔁 10    💬 2    📌 2

This was a fun collaboration between many scientists in the lab (go sponge team!), as well as our dear collaborators Renee Chang and Philip Kranzusch

Read the thread by talented scientist Nitzan Tal, who led the study, explaining our discoveries:

bsky.app/profile/nitz...

14.07.2025 07:36 — 👍 5    🔁 1    💬 0    📌 0

Successful phage therapy in a patient with prosthetic joint infection

Phage therapy in a patient with prosthetic join infection in Spain! Another sucessful treatment from the #EnBiVir #VLCphagehunters @i2sysbio.es and #EvolvingTherapeutics in collaboration with Dr. de la Villa #GregorioMarañon
@uv.es
@csic.es

www.sciencedirect.com/science/arti...

11.07.2025 14:52 — 👍 15    🔁 3    💬 1    📌 3