siTOOLs Biotech

Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation Extending a protein at its end affects its stability, but also its translation efficiency and even selection of its start.

🧬 A new report in Science Advances highlights how nonstop-mutations can alter translation initiation

Point mutations can affect all levels of gene expression, leading to #dysregulation and #cancer. Pal et al., Sci. Adv.
Read the full paper here: www.science.org/doi/full/10....
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19.02.2025 10:17 — 👍 1    🔁 0    💬 0    📌 0