Javi Ibarrondo

Distinct spatial organization governs oral mucosal immunity - Nature Immunology Moutsopoulos, Williams and colleagues show oral mucosal barrier tissues exhibit dynamic zonal immune cell environments, including tonic inflammatory features in healthy individuals and development of ...

www.nature.com/articles/s41... 🧪

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates - Nature Immunology WIN332 is an HIV-1 Env protein designed to elicit a new class of Asn332-glycan-independent antibodies (type II) to the V3-glycan site of Env. WIN332 immunization rapidly induces type-II V3-glycan anti...

www.nature.com/articles/s41... 🧪

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - Nature Immunology Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

www.nature.com/articles/s41... 🧪

Microbes might be able to planet hop on asteroid shrapnel Experiment confirms bacteria could survive being blasted off world by impact

Microbes might be able to planet hop on asteroid shrapnel | Science | AAAS www.science.org/content/arti... 🧪

Delays in awards and funding calls worry NIH-funded researchers Many programs may be pushed into the next fiscal year, and some could face funding gaps

Delays in awards and funding calls worry NIH-funded researchers | Science | AAAS www.science.org/content/arti... 🧪

Stem cell therapies ‘come of age’ with two conditional approvals in Japan Induced pluripotent stem cells could help treat diseased hearts and brains

Stem cell therapies ‘come of age’ with two conditional approvals in Japan | Science | AAAS www.science.org/content/arti... 🧪

Did ancient Greek priestesses brew a mind-bending potion drunk by Cicero and Marcus Aurelius? Researchers found the psychedelic elixir would have been possible to make using ingredients and techniques available in ancient Greece

Did ancient Greek priestesses brew a mind-bending potion drunk by Cicero and Marcus Aurelius? | Science | AAAS www.science.org/content/arti... 🧪

www.cambridge.org/core/journal... 🧪

The theory of epidemics with altruism | PNAS Social distancing can mitigate the spread of diseases in humans and animals. Social distancing allows susceptible individuals to protect themselves...

The theory of epidemics with altruism | PNAS www.pnas.org/doi/10.1073/... 🧪

‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication European regulators greenlight new one-dose compound that could help African countries get rid of an ancient burden

‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication | Science | AAAS www.science.org/content/arti... 🧪

Suspended small business research programs derail development of gene therapies, hip implants, and more Congressional impasse has halted billions in research funding for innovative technologies

Suspended small business research programs derail development of gene therapies, hip implants, and more | Science | AAAS www.science.org/content/arti... 🧪

How will we know if AI is smart enough to do science? New tests gauge whether large language models can use their deep troves of knowledge to actually make discoveries

How will we know if AI is smart enough to do science? | Science | AAAS www.science.org/content/arti... 🧪

Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

Meet three scientists who said no to Epstein | Science | AAAS www.science.org/content/arti... 🧪

Every senator who voted to confirm RFK Jr owns this tragedy. Every single one.

When I lost my university email, my identity as a scientist took an unexpected hit “My scientific life [had] gathered there, thread by thread,” this researcher writes

When I lost my university email, my identity as a scientist took an unexpected hit | Science | AAAS www.science.org/content/arti... 🧪

Private money cannot replace public funding of science Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Health—particula...

Private money cannot replace public funding of science | Science www.science.org/doi/10.1126/... 🧪

NSF officials break silence on how AI and quantum now drive agency grantmaking Leaders acknowledge White House role in controversial moves

NSF officials break silence on how AI and quantum now drive agency grantmaking | Science | AAAS www.science.org/content/arti... 🧪

Surprising partner preference found in matings between Neanderthals and modern humans Male Neanderthals tended to pair up with female modern humans, but whether intercourse was consensual is unclear

Surprising partner preference found in matings between Neanderthals and modern humans | Science | AAAS www.science.org/content/arti... 🧪

Treating fetuses with stem cells proves safe in milestone spina bifida trial The study is now scaling up to do more in utero procedures and evaluate effects on disability as children grow

Treating fetuses with stem cells proves safe in milestone spina bifida trial | Science | AAAS www.science.org/content/arti... 🧪

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

www.nature.com/articles/s41... 🧪

Synthesizing scientific literature with retrieval-augmented language models - Nature A specialized, open-source, retrieval-augmented language model is introduced for answering scientific queries and synthesizing literature, the responses of which are shown to be preferred by human eva...

www.nature.com/articles/s41... 🧪

Controversial citizenship question added to upcoming census test Researchers worry question plus other changes will reduce accuracy and boost costs of 2030 count

Controversial citizenship question added to upcoming census test | Science | AAAS www.science.org/content/arti... 🧪

Birds are vanishing from tropical forests. Is another ‘silent spring’ coming? As mysterious bird declines crop up in the Amazon and beyond, scientists suspect climate change may be to blame

Birds are vanishing from tropical forests. Is another ‘silent spring’ coming? | Science | AAAS www.science.org/content/arti... 🧪

U.S. science agency moves to restrict foreign scientists from its labs Proposed rule at National Institute of Standards and Technology would limit access to a few years for international researchers and students

U.S. science agency moves to restrict foreign scientists from its labs | Science | AAAS www.science.org/content/arti... 🧪

Censorship and safety concerns cloud China’s plans to host science journalism conference Organizers of the 2029 World Conference of Science Journalists defend Beijing meeting as opportunity to connect with Chinese scientists

Censorship and safety concerns cloud China’s plans to host science journalism conference | Science | AAAS www.science.org/content/arti... 🧪

‘I Genuinely Am Upset That Your Kids Are Vaccinated’ Del Bigtree, a longtime ally of Robert F. Kennedy Jr., isn’t just anti-vaccine. He’s pro-infection.

www.theatlantic.com/health/2026/... 🧪

Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation - Nature HIV remission of more than 6 years was achieved in a patient with functional viral co-receptors after CCR5 wild-type/Δ32 allogeneic stem cell transplantation, providing evidence of other mechanisms th...

www.nature.com/articles/s41... 🧪

Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors Kabil et al. show that early-life exposure to microbiota-derived SCFAs imprints long-lasting chromatin states in hematopoietic stem and progenitor cells. Allergic disease susceptibility is transferabl...

Early-life microbiota skews long-term gene expression and chromatin states of bone marrow hematopoietic precursors: Cell Reports www.cell.com/cell-reports... 🧪

Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity Shibl et al. conduct a comprehensive multi-omics analysis of the oral microbiome in obesity, revealing distinct microbial and metabolic profiles. Obese individuals show enrichment of proinflammatory, ...

Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity: Cell Reports www.cell.com/cell-reports... 🧪

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools Stunault et al. show that the ketogenic diet drives extensive transcriptional reprogramming of the hippocampus through histone post-translational modifications, leading to altered short-term plasticit...

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools: Cell Reports www.cell.com/cell-reports... 🧪