euanashley

🎧 NEW on The Future of Medicine: #StanDOM's @euanashley.bsky.social & @kbibbinsdomingo.bsky.social, physician, epidemiologist & Editor-in-Chief of @jamanetworkopen.com, discuss how today's most influential #MedicalResearch gets evaluated, debated & ultimately published. https://bit.ly/43LGRZv

🎧 ICYMI: Mark Skylar-Scott joins #StanDOM's @euanashley.bsky.social to discuss what it will really take to bioprint living tissues, & why solving vascularization (the blood vessel network) is essential before engineered organs can become reality. https://bit.ly/43LGRZv

🎧 NOW LIVE on The Future of Medicine: Anna Lembke, Stanford psychiatrist & author of #DopamineNation, discusses the impacts of digital media, compulsive overconsumption, addiction, recovery & the science of pleasure & pain. Hosted by #StanDOM's @euanashley.bsky.social. https://bit.ly/43LGRZv

Thanks to @stanfordmedicine.bsky.social comms team for the feature on our epistasis work led by Qianru Wang! Strong Falcon tube inspection skills from Ben Viggiano in the background!

med.stanford.edu/news/insight...

ICYMI: @mcuban.bsky.social, entrepreneur and founder of @costplusdrugs.com, joins #StanDOM's @euanashley.bsky.social on The Future of Medicine to unpack why patients, clinicians & hospitals are caught in a system driven by misaligned incentives. https://bit.ly/43LGRZv

Coming Jan. 12 on The #FutureOfMedicine: Entrepreneur, investor & founder of @costplusdrugs.com, @mcuban.bsky.social joins #StanDOM's @euanashley.bsky.social to discuss what's broken in U.S. healthcare — from drug pricing to insurance incentives.

The Future of Medicine - YouTube Welcome to The Future of Medicine, a podcast from the Stanford Department of Medicine. Each week, we bring you into conversation with the thought leaders who...

We also talk about how Cost Plus aims to disrupt the (frankly insane) way that medicines make it from the pharma companies that develop them to the patients who need them.
www.youtube.com/playlist?lis...

More than that, he puts his money where his mouth is. In this wide ranging conversation in front of a live audience at Stanford Health Care we discuss what is broken about the health care system and what we can each do to fix it.

YouTube video by Stanford Department of Medicine Mark Cuban on Broken Healthcare, Drug Prices, and Reform

We were excited to host Mark Cuban at Stanford. While most of us know him from Shark Tank or the Dallas Mavericks (and we talk about that too!) Mark is, surprisingly to some, one of the most insightful analysts and commentators on our health care system today.
www.youtube.com/watch?v=_I3r...

Nobel laureate & co-discoverer of CRISPR-Cas9 Jennifer Doudna is this week's guest on the Future of Medicine podcast hosted by @euanashley.bsky.social. Here's a link to the episode: thefutureofmedicine.buzzsprout.com #CRISPR #biosky #medsky

Power Transfer What health insights from elite athletes can do for every body.

Fun feature on our Elite study, part of the Wu Tsai Human Performance Alliance.
stanfordmag.org//contents/po...

Coming next week on The Future of Medicine: Jennifer Doudna, a Nobel Prize–winning biochemist & the co-inventor of CRISPR gene editing! #StanDOM's @euanashley.bsky.social & Doudna discuss scientific curiosity, responsible innovation, gene editing & more. https://bit.ly/43LGRZv

The Future of Medicine Medicine Podcast · Welcome to The Future of Medicine, a podcast from Stanford's Department of Medicine.  We bring you into conversation with the thought leaders who are reshaping how we understand di...

Sumbul is one of our former trainees and current adjunct faculty member. We talk about her life story and the moments that led her to a position where she leads health products that impact hundreds of millions.

Apple: podcasts.apple.com/ca/podcast/t...
Spotify: open.spotify.com/show/5z15Lom...

YouTube video by Stanford Department of Medicine Wearables, Hypertension Prediction, and the Patient–Physician Dyad with Sumbal Desai

Episode 2 of our video podcast series The Future of Medicine drops today! In front of a live audience at Stanford University, I had a chance to chat to Sumbul Desai, Vice President of Health at Apple.
www.youtube.com/watch?v=TXRj...

Something new is coming from #StanDOM on Dec. 1! Introducing The Future of Medicine, a new podcast built from the extraordinary speakers who join us for #StanDOMGrandRounds & hosted by our Chair, @euanashley.bsky.social. Subscribe on your favorite platforms at https://bit.ly/43LGRZv

sorry. right link at the end.

www.science.org/doi/10.1126/...

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of cardiovascular disease—can raise circulating low-density lipoprotein (LDL) cholesterol concentrations and i...

Amazing work from Daniel, Fritz and team!

Paper: www.science.org/doi/10.1126/...
Variant effect map review: www.nature.com/articles/s41...
Cardiovar consortium: www.genomeweb.com/research-fun...
Atlas of variant effect maps: www.mavedb.org

These sorts of maps will increasingly become central tools in our quest to understand disease-causing human genes to help patients and prevent disease.

Further, functional scores correlated with hyperlipidemia phenotypes in prospective human cohorts and augmented polygenic scores to improve risk inference.

This yielded sequence–function maps that recapitulate known biochemistry, offer functional insights, and provide evidence for interpreting clinical variants.

Here, Daniel and team tested the impact of nearly all possible (~17,000) missense coding variants in the receptor for LDL ("bad cholesterol"), the gene most commonly responsible for FH. Importantly, they tested two functional readouts: LDLR cell-surface abundance and LDL uptake.

The new science of "variant effect mapping" uses cellular biology to model all possible variants in important genes in advance, providing scientists and clinicians with estimates as to their pathogenicity.

Familial hypercholesterolemia (FH) is among the most common inherited cardiovascular diseases. It causes early heart attacks that are preventable with modern therapy. The challenge is that many variants identified by sequencing are of unclear significance.

So excited about this new work from our CardioVar consortium out this week in Science led by the amazing Daniel Tabet and @fritzroth.bsky.social.

www.science.org/doi/10.1126/

The credit for this honor goes to my team and the incredible environment here at Stanford University. I am so grateful for the opportunities that this special place has afforded me.

Honored to join Benjamin Meder and treasured colleagues at the 10th anniversary celebration of the Institute for Cardiomyopathies in Heidelberg. Hot on the heels of our Leducq Network meeting on cardiac splicing! Thanks for wonderful hospitality and stimulating science.❤️

Stanford Medicine magazine reports on chronic disease prevention, diagnostics, care The new issue of Stanford Medicine magazine explores advances in diagnostics, prevention and therapy that are lifting the burden of chronic conditions.

Chronic disease represents an enormous individual and societal toll that is mental, physical, and financial. Stanford Medicine Magazine focuses on what our @stanfordmedicine.bsky.social faculty are doing to address this.

med.stanford.edu/news/all-new...

Huge thanks to Geoffrey Ginsburg for the idea for the symposium and to fellow Glaswegian Stephen Kingsmore for co-chairing. At the following session, we enjoyed a lively discussion on the future of AI in healthcare.

Atul and his legacy will not soon be forgotten. ❤️

I had the honor of remembering and celebrating our friend Atul Butte today at a special symposium at the AGBT Precision Health meeting in San Diego. I shared the stage with superstars Chris Longhurst, Marina Sirota, Lucila Ohno-Machado, and Bimal Chaudhari.