Gabriele Laudadio

Over the moon sharing that our work is online in JACS @pubs.acs.org!

You can find the published version here (Open Access):

pubs.acs.org/doi/10.1021/...

We tested this approach with four different anodic transformations, scope and intensification included. Also, the students had a lot of fun digging out snow and defrosting salt from the frosty Graz roads to run a robustness reaction (detailed info in the SI).

... And this is why

By combining these two solvents, we achieved the use of simple inorganic electrolyte salts without compromising the solubility of organic compounds. The use of high mass-transfer electrochemical reactors is the key to promoting this solvent switch.

Electrochemistry to the next sustainable level: In our first work of the year, we present a general water/propylene carbonate mixture to carry out anodic reactions.

Check it out!

t.co/vKTiLTF0ga

Could we please avoid comparison? I am sensitive to this. Calzone IS NOT an empanada. They are both delicious, but in different ways 🤣🤣🤣

A current take on the Swern oxidation Electrochemical update to a classic reaction trades cryogenic conditions for room temperature, to selectively convert primary and secondary alcohols into aldehydes and ketones

An electrochemical approach to the classic Swern oxidation converts alcohols to aldehydes and ketones at room temperature, eliminating the need for dangerous reagents and extreme conditions.

I think this initiative was more to have an AI that can spark constructive criticism on a scientific work, rather than a mere expedient to circumvent our duty as peer-reviewers. As always, it depends on how you use the tool, isn't it?

I totally agree John, it happened to me to receive sus peer review, but how would you prove it? I mean, how could I sustain the argumentation of an alleged AI peer-review? :(

I totally agree... MOF has been in the shortlist for a while...

Since the review is about the modular nature of these platforms and how they were exploited in the literature, puzzle pieces came up pretty naturally. My biggest problem was filling the lab bench in back 😬

Thanks for the kind words! The idea of the e-chem robot dreaming about automating itself was something that was bugging my head for a while! That was where the whole concept started :)

I had a lot of fun designing the cover. It started from a simple concept: I wanted to revisit a classic in sci-fi literature. My wife sketched the idea for me, the rest is history :) #chemsky

Automating Synthetic Organic Electrochemistry: Concepts and Advancements A tutorial review on how to build an automated electrochemical flow platform, including the most relevant progresses and the future directions of the field, is studied.

Interested in automating your electrochemical reaction? Check our tutorial review on automation in synthetic organic electrochemistry, online open access on Chemistry Methods

Modules description and relevant examples, all in one document!

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)

(12/12)

It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.

(11/n)

Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)

And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).

But if the potential required is so low, how can this work?? (9/n)

During the scope we identified some key requirements for successful substrates... (8/n)

Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)

So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)

... Why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)

But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)

In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)

In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)

We are proud to present our work on something really special, appeared in
@ChemRxiv
today. We unlocked the synthetic application of DMF distonic radical anion with electrochemistry!

Interested in the full story? See below! (1/n)

chemrxiv.org/engage/chemr...

And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)

(12/12)

It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.

(11/n)

Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)

And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).

But if the potential required is so low, how can this work?? (9/n)