Mingqi Han

Call for applications: A fifth edition for the Early-Career Scientist Seminar Series

You are a postdoc looking for an opportunity to present your latest work and discuss with leaders in the field? Apply to the early career scientists seminar series @ircm.bsky.social ! If selected, we pay for your expenses to come spend a day with us and give a seminar! www.ircm.qc.ca/en/news-deta...

Nanotubes everywhere between neurons! A bit skeptical about these "dendrite-dendrite nanotubes" from a phalloidin staining in culture, but let's read on… www.science.org/doi/10.1126/...

Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem

giottosuite.com

Multi-slice/-modal registration

Joint cell type annotation⬅️ multiple segmentation

Integrated modalities-based Leiden clustering

@natmethods.nature.com 2025
www.nature.com/articles/s41...

Good Sunday, all. This week has seen some beautiful papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary, find it here:

biomed.news/bims-camemi/...

@biomednews.bsky.social #keepreading 💥 📚

"The real meditation is how you live your life."-Jon Kabat-Zinn

This is an essential understanding! Very grateful such comprehensive analysis was conducted and shared 😇

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

An unexpected career in cancer metabolism Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I

Look forward to connecting with new friends and colleagues in Texas! I've got my cowgirl boots, hat, and photo with @bucees.bsky.social, what's next?

Very grateful for the guidance and support I received during my faculty search, having encouraging colleagues makes all the difference! @Stefano Soatto (UCLA Vision Lab), Orian Shirihai (UCLA), Andrew Goldstein (UCLA) and Roger Reddel @cmri.bsky.social

Excited to share that I'm joining the Cancer Systems Imaging (CSI) @mdanderson.bsky.social as Assistant Professor this July! My lab focus on cancer metabolism and quantitative imaging. We're looking for a highly motivated postdoc to explore "metabolism visualization" across scales!

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress respon...

Unravelling cysteine-deficiency-associated rapid weight loss

www.nature.com/articles/s41...

Great work by @rushika-perera.bsky.social!

Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function Nature Cell Biology - Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by...

Excited to share new report from collaborative work from @delgoffelab.bsky.social and @patrickjonker.bsky.social from our team on a novel metabolic suppressor of T cell function in tumors! rdcu.be/eiyIa 1/

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!

We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!

www.sciencedirect.com/science/arti...

Abstract deadline for UMDF 2025 is TODAY! Submit your abstracts here: umdf.smapply.org/prog/2025pos...

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection Nature Communications - Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately...

🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...

Glycogen drives tumour initiation and progression in lung adenocarcinoma - Nature Metabolism Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

Fascinating work from MALDI master Ramon Sun and collaborators on glycogen metabolism in NSCLC. A real tour de force and such beautiful images 😍 www.nature.com/articles/s42...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral ...

Increasing evidence for the central role of peroxisomes in antiviral immunity. A new study provides in vivo evidence to support a role for peroxisomes in SARS-COV-2 infection. Kudos to the authors on this important study.
www.science.org/doi/10.1126/...

Rare cellular events observed in the cryo-ET dataset. Slices through tomograms (left) with corresponding 3D segmentation (middle and right). Right panels show enlarged views of the boxed regions in the middle panels. A) Mitochondrion at the plasma membrane, tethered to microtubules by thin filaments of unknown identity. Segmented classes: nuclear envelope (light blue), nuclear pore complex (dark blue), 80S ribosomes (orange), mitochondrial membranes (dark red), ATP synthase (royal blue), plasma membranes (grey), microtubules (pink), filaments (yellow), endoplasmic reticulum (purple). Zoomed-in panel shows thin filaments running between microtubules and the mitochondrion at the plasma membrane. Note that this tomogram contains two closely appressed cells, and thus, two plasma membranes with cell walls between. B) Mitochondrial fission event with ER membrane interactions. Segmented classes: mitochondrial membranes (dark red), ATP synthase (royal blue), 80S ribosomes (orange), thylakoid membranes (green), PSII (bright yellow), cell wall (grey), ER (purple), fission site containing filamentous structures perpendicular to the mitochondrial long axis (pale yellow). C) Ciliary transition zone between basal body and axoneme, including assembling IFT train and stellate structure77. Segmented classes: microtubule doublets (light blue), central microtubule pair (light green), stellate structure (pale red), IFT train (yellow). D) Pyrenoid tubule extending from the thylakoids into the phase-separated Rubisco matrix of the pyrenoid. Minitubules originate from thylakoid membranes82. Segmented classes: thylakoid membranes (dark green), PSII (yellow), pyrenoid tubule (lime green), Rubisco (lavender blue), minitubules (orange). Scale bars in A-D: 100 nm. Related to Fig. 2C-H.

To all #TeamTomo #CryoET and #Chlamydomonas aficionados: we have updated EMPIAR-11830 with a bug fix concerning some cryo-CARE denoised tomos as well as additional files and metadata! 🎉👩🏽‍💻

www.ebi.ac.uk/empiar/EMPIA...

A little thread about what's new... 🧵 1/n

Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling Building predictive models of the cell requires systematically mapping how perturbations reshape each cell’s state, function, and behavior. Here, we present Tahoe-100M , a giga-scale single-cell atlas...

#scRNAseq to the next level: www.biorxiv.org/content/bior.... Mindbogglingly 100M cell large dataset involving 50 cancer cell lines and 1,100 molecule perturbations 🤩 — an absolute feast for the data-hungry ML/AI field, poised to advance cell understanding and modeling.

📢 Postdoc Opening – Metabolism & Cancer! 📢
Looking for a motivated postdoc to explore how metabolism regulates tumor initiation at Roswell Park in Buffalo, NY! Join us to tackle big questions with cool science in a collaborative environment.
Interested? DM me! #PostdocJobs #CancerMetabolism

1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the consequences of compromised mitochondria in metabolic tissues are often unclear. Here, we report that dysfunctiona...

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science www.science.org/doi/10.1126/...

Registration and abstract submissions are open for the Third Annual SoCal Metabolism Symposium at USC. Go to gero.usc.edu/event/third-... The abstract and early bird price deadlines are Feb 28th

"Adaptations of #neutrophils in #cancer"

Ng et al, 2025

A great new review on these fascinating immune cells!

In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩

@cp-immunity.bsky.social

www.cell.com/immunity/iss...

www.cell.com/immunity/abs...

Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Delighted for my first Bluesky post to be in celebration of the work of Ronnie (@nightscientist.bsky.social) — can’t say enough about his talent & creativity! If you’re interested in the link between dietary fructose and cancer, check out his paper.
#metabolomics

www.nature.com/articles/s41...

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

"Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer"

Congrats to @gjpattij.bsky.social & team

www.nature.com/articles/s41...

Hi everyone, really enjoy the fresh air here and meeting new people! Thanks to @colemanlab.bsky.social for the nudge! We study everything related to mitochondria. Hope to form more connections and conversations! Some blue sky pics from a fantastic nature conference on mito and immunity in September.