Jonathan Slaughter MD

Whole-Body Hypothermia for Neonatal Encephalopathy This randomized clinical trial investigates if hypothermia initiated at less than 6 hours after birth reduces the probability of death or disability at 18 to 22 months’ corrected age in infants 33 to ...

Preterm cooling trial published, previously presented at PAS 2023.

No difference in primary outcome. Bayesian analysis suggests 87% probability of increased risk of death with hypothermia. Practice changing for those who are cooling this population?

#neobluesky

jamanetwork.com/journals/jam...

I guess it's not surprising that our organizations and journals must lag a bit in adoption of a new platform, but they are an important part of the conversation. Let's encourage whatever we're affiliated with to take the leap. We can log them here (currently pretty sparse)

go.bsky.app/DwfZqQF

Updated meta-regression by Prof Lex Doyle et al. in JAMA Pediatrics examines how potential benefit from Dexamethasone and Hydrocortisone changes with baseline risk of BPD among included trials. #neoEBM #neosky #EBNEOalerts
buff.ly/3CNa6Ae

Definitely some great references for research writing and reviewing. I recommend this for all clinical and epidemiological research learners out there. Thanks for posting Sara!

Important article on Dexamethasone: Doyle LW, Mainzer R, Cheong JLY. Systemic Postnatal Corticosteroids, Bronchopulmonary Dysplasia, and Survival Free of Cerebral Palsy. JAMA Pediatr. Published online November 18, 2024. doi:10.1001/jamapediatrics.2024.4575

jamanetwork.com/journals/jam...

Time to regroup and like a phoenix, rising from the ashes, reunite here where the skies are so beautifully blue
go.bsky.app/5GFC5VL
#NeoSky

Prophylactic Acid-suppression Medication to Prevent Anastomotic Strictures After Oesophageal Atresia Surgery: A Systematic Review and Meta-analysis Anastomotic stricture is a common postoperative complication of oesophageal atresia ± tracheoesophageal fistula (OA/TOF) repair. Acid gastro-oesophage…

A friendly reminder to #NeoSky on a pet topic:
PPIs have very little evidence of benefit in neonates and potential for harm.
We did a systematic review of acid suppression after TOF/OA (EA/TEF) repair and found no benefit: www.sciencedirect.com/science/arti...

To start things off - we'll share a couple of our recent #ebneoalerts.

Results of the PLUSS trial led by @drbretty.bsky.social published in JAMA.

Paper: buff.ly/48Kmhtz
Editorial: buff.ly/40HxadL

#neoEBM #EBNEOAlerts #neoSky