Fitz-James Lab

Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488 We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Heterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular Biology Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.

Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4

www.nature.com/articles/s41...

WE ARE RECRUITING PHD STUDENTS!!!

We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.

#Drosophila #Evolution #Immunity #SelfishGene #Aphids

Thread with links below 🧵 1/4

It’s been a big month for the lab! We’ve gone from just me to six in as many weeks. I’m so excited to embark on this new chapter with these wonderful people, and I’m looking forward to the exciting science 🧪we’ll be doing together in the new Life and Mind Building @biology.ox.ac.uk
#epigenetics

Excited to be presenting my work today at @biochemsoc.bsky.social event Transcription and Chromatin UK!

Would love to be added as well please!

Last day of #SMBE2025 in Beijing!
It was a real pleasure to talk about epimutation on Tuesday and to get to know lots of new researchers and their exciting work!

Traveling to Beijing for @official-smbe.bsky.social #SMBE 2025. I have both a talk and a poster on Tuesday on different aspects of epigenetic inheritance. Stop by if you’re there!

🚨Fantastic PhD opportunity for Autumn 2025 with our colleague Rebekah Tillotson @uoe-igc.bsky.social, asking whether ATRX syndrome is treatable:
sidb.org.uk/phds/tillots...
Please share 🙏
#epigenetics #raregeneticdisease #chromatinopathies

Transcription and Chromatin UK Manchester, UK 17-19 September 2025 Earlybird deadline: 17 July 2025

Taking place on 17-19 September 2025, Transcription and Chromatin UK will showcase cutting-edge research and is a ‘mustattend’ for anyone within the transcription and epigenetics community🧪. Register now: www.eventsforce.net/biochemsoc/2...

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Great opportunity in a fun lab / cool city!

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal.

We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers
🧪 #AcademicSky

www.nature.com/articles/d41...

Clarifying the public misrepresentation of transgenerational epigenetic inheritance - Theoretical Medicine and Bioethics Theoretical Medicine and Bioethics -

A nice short reminder to be wary of the press overstating scientific claims

link.springer.com/article/10.1...

🚨Job Alert🚨

We are looking for a technician to join us in Oxford @biology.ox.ac.uk to study epigenetics and vibration-sensing:

my.corehr.com/pls/uoxrecru...

The work will be varied:
Arthropod culture 🕷️🪰
Lab work (DNA/RNA extraction, sequencing library preparation…)

Apply by Mon 23 June
🧪

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

Very cool paper combining two of my favourite things: phylogeny and genome organisation

Fly Open access research on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination

Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.

Our new review in @cp-trendscellbio.bsky.social is now online! We discuss the connection between the epigenome, 3D genome folding, gene expression and cellular memory, specifically in loop extrusion-independent contexts.

Postdoctoral Research Associate at University of Oxford Discover Postdoctoral Research Associate jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

TWO postdoc positions in Computational Microbiology and/or biochemistry. Join our interdisciplinary group in the new Life and Mind Building @OxfordBiology, @UniofOxford, @IneosOxford
Please apply and share this post:
www.jobs.ac.uk/job/DMP641/p...

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

Something to ponder when considering which journal to submit to. Society owned journals are an important source of income for the community.

10/10 Very happy to have this paper out and for the wonderful work done with Peter and our students Poppy and Chris!

9/10 While we can’t fully explain this effect, this downregulation of Pho, with potential downstream effects on Polycomb targets, may be something to keep in mind when using Sb as a marker in future.

8/10 In following up on this unexpected result, we found that mutation of Sb has an effect on expression of Pho, a recruiter of the PRC2 complex responsible for depositing H3K27me3.

7/10 As controls for our sRNA pathway mutants we used some well-known marker mutations on the same chromosome. One of these, mutation in the gene Stubble (Sb) which is well-known to Drosophila enthusiasts, had a clear effect on eye colour, making it more red.

6/10 Next, we tested an array of mutants in sRNA pathways. Again, we found no effect of the mutations on eye colour, arguing against a role for sRNAs in eye colour. However, a surprising result involving one of our controls jumped out at us…

5/10 We decided to investigate whether sRNAs were contributing to Fab2L eye colour and its inheritance. First, we sequenced sRNAs in a variety of Fab2L lines with epigenetic and phenotypic differences. But we found no sRNAs mapping to the eye colour gene.

4/10 In many organisms (C. elegans, plants…) small non-coding RNAs are known to be passed through the germline and are often considered the true directly inherited signal, with other epigenetic signals being derived from them.

3/10 But is H3K27me3 the only epigenetic information involved? Epigenetic signals often work together, making it hard to tell if a particular signal is truly inherited, or simply reconstructed in each generation based on another inherited signal.