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@brumbaugh-lab.bsky.social

84 Followers  |  73 Following  |  11 Posts  |  Joined: 09.01.2025
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I am a member of the Global Workforce Development Working Group. Learn more.

(2/2) Our goal is to identify workforce needs and develop actionable recommendations to support career development in stem cell biology & regenerative medicine. Stay tuned for a survey that will help us evaluate challenges and opportunities across the field.

Learn more here: invt.io/1lxbkk3mjye

11.02.2026 04:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The @isscr.org and @stemcellnetwork.ca have launched a working group on Global Workforce Development in Stem Cell Research and Regenerative Medicine. I'm excited to co-chair this initiative with Dr. Danielle Spice and to work with an impressive set of trainees and early-career investigators. (1/2)

11.02.2026 04:41 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Cool study from the @efapostolou29.bsky.social looking at plasticity in B cells. Check it out!

03.01.2026 15:32 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

The @isscr.org and @stemcellnetwork.ca have launched an important initiative to understand the needs of both employers and the future workforce. Check out the information below and consider applying to join the working group or nominate someone that you feel could provide good perspective!

15.11.2025 04:22 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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There are many ways to make your voice heard and participate in all that the #ISSCR2026 Annual Meeting has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1lxby1coomp @isscr.org

04.11.2025 01:41 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Fun project with @distefanolab.bsky.social looking at RNA regulation in cell fate decisions. Check out the great summary below and see the full work in @natbiotech.nature.com: www.nature.com/articles/s41...

29.10.2025 02:45 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

28.10.2025 18:50 β€” πŸ‘ 45    πŸ” 14    πŸ’¬ 2    πŸ“Œ 1

Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.

13.05.2025 03:12 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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I am a 2025 ISSCR Public Service Award Honoree. Learn more

Thanks to @isscr.org for this wonderful recognition! And thanks to my colleagues and ISSCR for thoughtfully and carefully working on important policy and regulatory matters. Read more about the award and my fellow honorees. invt.io/1bxbk540w9k @isscr.org

27.03.2025 01:00 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thanks to @cp-cellchembiol.bsky.social, @iamzico.bsky.social and Ramesh Shivdasani for this thoughtful discussion of our work!

27.03.2025 00:54 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...

Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells

13.03.2025 20:41 β€” πŸ‘ 14    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...

πŸ’«NEW: @brumbaugh-lab.bsky.social, Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in #regeneration.
πŸ‘‰πŸΏhttps://rdcu.be/eayN3
www.nature.com/articles/s41...

19.02.2025 21:35 β€” πŸ‘ 20    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

πŸ₯‚Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration.
rdcu.be/d8awu
www.nature.com/articles/s41...

31.01.2025 13:49 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
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Biomolecular condensates in immune cell fate - Nature Reviews Immunology Recent studies suggest that biomolecular condensates β€” membrane-less assemblies of proteins and nucleic acids β€” are involved in regulating gene expression to ensure proper immune cell development. Thi...

1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

28.01.2025 16:39 β€” πŸ‘ 40    πŸ” 16    πŸ’¬ 2    πŸ“Œ 2

Thanks!

11.01.2025 02:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thank you!

11.01.2025 02:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

10.01.2025 05:22 β€” πŸ‘ 24    πŸ” 9    πŸ’¬ 1    πŸ“Œ 2