Jim Januzzi

Selective in vitro enhancement of cardiac myosin motor function and myofilament force generation by danicamtiv prompted clinical evaluation. A short course of danicamtiv was generally well tolerated in participants with #DCM https://bit.ly/4mE3vcM

#HFSA2025 #JACC #cvGenetics @jimjanuzzi.bsky.social

The Short and Sweet on Sodium–Glucose Cotransporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure Heart failure (HF) affects 6 million people in the US, and type 2 diabetes (T2D) is a significant risk factor for HF. Since 2008, regulatory agencies have required cardiovascular safety trials

Short & sweet! Check out our review of #SGLT2i & #GLP1RA in #HeartFailure! Great work Jose Lopez & team! @ucsfcardiology.bsky.social @amitgoyalmd.bsky.social @robmentz.bsky.social @dranulala.bsky.social @jimjanuzzi.bsky.social @sjgreene-md.bsky.social

www.uscjournal.com/articles/sho...

Great presentation by @jimjanuzzi.bsky.social at #ACCAsia in Singapore on optimizing decongestion using diuretics and GDMT in patients with HF. Access more HF resources in the @accintouch.bsky.social Guidelines Hub: acc.org/guidelines

Get to Know Your Leaders | Leading With Purpose:
Meet Chris Kramer, MD, FACC
@chriskramermd.bsky.social
#CardiologyMagazine
#CardioSky
www.acc.org/Latest-in-Ca...
@accintouch.bsky.social @jaccjournals.bsky.social @jimjanuzzi.bsky.social @drmarthagulati.bsky.social @vietheartpa.bsky.social

The weekend cannot come fast enough.

Imbria secures $57.5m to advance ninerafaxstat through Phase IIb trial Imbria has secured $57.5m in a Series B funding round to support the progression of ninerafaxstat through a Phase IIb trial in nHCM.

Hope for tx of nHCM:

According to the company, this partial fatty acid oxidation (pFOX) inhibitor is an oral compound that promotes a shift in the heart’s preference from fatty acids to glucose, resulting in energy generation by the mitochondria.

#HCM #CardioSky #Cardiomyopathy #Cardiology

Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure

#EJHF @escardio.bsky.social
#CardioSky @shelleyzieroth.bsky.social @jimjanuzzi.bsky.social @drmarthagulati.bsky.social @cardioobdoc.bsky.social

When I see something like this, I promise the patient that with the effort of initiating and titrating #GDMTworks, they can expect a bounce in their LVEF. In this case--since she's naive to therapy--likely a lot.

Back to the Garden with @julijanuzzi.bsky.social

@celticsnba.bsky.social

I am so incredibly grateful to the @accintouch.bsky.social for the honor of being named the 2025 Distinguished Clinical Researcher.

I am blessed to have stood on the shoulders of giants during my career and am thankful to @mgbresearch.bsky.social and #BaimInstitute for support.

Congratulations @jimjanuzzi.bsky.social
Very well deserved 👏👏

Thank you so much @dradastefanescu.bsky.social!

Congratulations @jimjanuzzi.bsky.social on your @accintouch.bsky.social Distinguished Scientist Award!! #ACC25

Congratulations to new #ACCPresident Christopher M. Kramer, MD, FACC! Inspired by a movie classic, he shared: “Today I want to talk to you about two Fantastic Voyage-Related themes: innovation and mentorship.”

💬 bit.ly/41RJlF6 @ChrisKramerMD #ACC25 #ACCLeadership

FRESH-UP Trial #ACC25 #medsky

RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF

🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction

www.nature.com/articles/s41...

Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial - Nature Medicine While fluid restriction is typically recommended for patients with chronic heart failure, this randomized clinical trial showed no difference in health status, as assessed by patient-reported outcomes...

Fluid restriction associated with trend to worse QoL and greater thirst in stable outpatients with HF. No difference in safety.
www.nature.com/articles/s41...

Terrific @accintouch.bsky.social @acc25 session on the intersection of heart failure and imaging. Great job @purviparwani.bsky.social @michaelsalerno.bsky.social moderating the interesting case-based discussions @jimjanuzzi.bsky.social

Opening day for the @redsox.com

Let’s go

#MLB2025 #DirtyWater

@heartbobh.bsky.social

Happy birthday to a person who makes the world more beautiful.

Walking the beach where just a few months ago our buddy was having the time of his life. Glad to share the moment together.

There are blue skies beyond this.

Happiest of birthdays, RSJ.

@robertasensen.bsky.social

I did not have habitually watching eaglets on my 2025 bingo card but we are completely here for #JackieandShadow and their babies.

#FOBBV #eagles @robertasensen.bsky.social

No idea--as hard as it was for me to do it with 18K+ followers, I suspect it'd be harder for him with half a million...

I haven't posted there in basically months and was using it largely to lurk and check news/scores. At the end of the day--definitely not worth it.

Enough is enough.

I have deleted my Twitter account.

Not worth it anymore.

75thgala - American College of Cardiology The ACC Foundation Anniversary Gala will unite our members, friends and partners to celebrate the remarkable achievements of the past 75 years and raise funds to continue advancing our Mission.

One more day to purchase tickets!

www.acc.org/75thGala

#cardiosky

thanks Rick! These days, finding the happy moments is more important than ever.

Courtside @thebostonceltics.bsky.social with @robertasensen.bsky.social and the fam.

In pts undergoing 99mTc PYP imaging for suspected #ATTR, hs-cTnT & NT-proBNP can effectively rule out diagnosis, although in a small subset of patients

#CardioSky
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @vietheartpa.bsky.social @load-dependent.bsky.social @jimjanuzzi.bsky.social

a broken clock is correct twice a day...but it's still broken.

Game time, Courtside with @julijanuzzi.bsky.social @thebostonceltics.bsky.social

a man with a beard and mustache is smiling and says `` do it '' . ALT: a man with a beard and mustache is smiling and says `` do it '' .

Send me an email--come on, do it.