Adeel 阿德

Taiwanese Innovators Pushing the Boundaries of Advanced Cell Manufacturing Technologies Since 2020, YJ Biotechnology has been transforming regenerative medicine with its cost-efficient, internationally-certified and decentralized one-stop cell manufacturing platform supporting industrial...

#Biotechnology #GeneticEngineering #Taiwan
Taiwanese Innovators Pushing the Boundaries of Advanced Cell Manufacturing Technologies
www.latimes.com/specialsuppl...

Since 2020, YJ Biotechnology has been transforming regenerative medicine with ...

Protocol for the isolation and characterization of murine hematopoietic stem and progenitor cell-derived extracellular vesicles Hematopoietic stem cells (HSCs) maintain their self-renewal capacity in an autocrine manner through hematopoietic stem and progenitor cell (HSPC)-derived extracellular vesicles (EVs). Here, we present a protocol for the isolation and characterization of EVs from HSPCs starting from an in vivo murine model. We describe steps for murine bone marrow isolation, HSPC staining and sorting, HSPC-derived EV isolation, size and concentration characterization, and EV visualization and marker description. ...

Protocol for the isolation and characterization of murine hematopoietic stem and progenitor cell-derived extracellular vesicles #protocol #starprotocols #cellpress

SERS Sensor for Acetylcholine Detection Based on Covalent Organic Framework Hybridized Gold Nanoparticles As Nanozymes http://dx.doi.org/10.1021/acs.analchem.4c02471

Open Access UCL Research: Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine-Learning for Tumor Therapy discovery.ucl.ac.uk/id/eprint/10...

My synthesis is not synthes-ing today, so hereby a throwback to a synthesis that did work out 🧪👩‍🔬

I have used these CeO2-nanoparticles both for ROS scavenging and NO releasing purposes.
doi.org/10.1021/acsa...
doi.org/10.1016/j.co...

#ChemSky #AcademicSky #QueerInSTEM #Nanozymes #HBOCs

Check out our new collaborative work with Dr. Kam Leong @columbiauniversity.bsky.social now out in Advanced Functional Materials! We developed oral nanoparticles to help mitigate hematopoietic acute radiation syndrome, especially in cases of deep space exploration:

t.co/1jQwcU1pDB

Watched last week’s TissueTalk with Prof. Irv Weissman (@StanfordMed, US)🧪

Was especially interested to hear the origin of the ‘don’t eat me/eat me’ signaling of CD47, which is something we wanted to explore with our membrane-coated HBOC NPs as well (1/2).

Online: www.youtube.com/watch?v=dKnA...

Safety Landscape of Therapeutic Nanozymes and Future Research Directions

A simplified hybrid capture approach retains high specificity and enables PCR-free workflow Hybrid capture is a critical technology for selective enrichment of genomic regions of interest, enabling cost-effective focused sequencing in both clinical and research applications. We present a sim...

A preprint by @elembio.bsky.social on an on flowcell simplified hybrid capture approach that retains high specificity and enables PCR-free workflow www.biorxiv.org/content/10.1...

One of the more exciting milk extracellular vesicles pre-prints I’ve had the pleasure of reading lately!
Well done to the Tiny Cargo company for taking it to the next level 🙌👏
Milk EVs are the future of nanotherapeutics 👌

Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases Noninvasive blood detection of brain-derived vesicles enables early and precise diagnosis of brain diseases.

Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases
Science Advances
www.science.org/doi/10.1126/...

Engineered extracellular vesicles as a next-generation vaccine platform EV vaccines can be engineered to be loaded with antigenic proteins and antigen-encoding RNAs by genetic engineering of parental cells or direct engineering of EVs. Due to possessing many of the key immunostimulatory properties of donor cells, EVs are capable of activating immune responses for vaccination against infectious diseases and cancers by direct antigen-presentation, semi-direct antigen-presentation, and indirect antigen-presentation pathways.

Engineered extracellular vesicles (EVs) are emerging as next-gen vaccines.

Safe and efficient, they target cancers and infectious diseases by delivering antigens and boosting immune response.

A promising leap in vaccine technology.

www.cell.com/matter/abstr...

Journal of Cell Science poster, ‘Extracellular vesicles and nanoparticles at a glance’ from Dennis Jeppesen, Qin Zhang and Robert Coffey.

In their Cell Science at a Glance article and associated poster, Dennis Jeppesen, Qin Zhang and Robert Coffey review the diversity and heterogeneity of extracellular vesicles and nanoparticles, including some recently identified examples.

journals.biologists.com/jcs/article/...

Clinical Applications of Circulating Tumor DNA Profiling in GI Cancers ascopubs.org/doi/pdf/10.1... @acochran12733.bsky.social @ethicsdoctorp.bsky.social @fumikochino.bsky.social @oncoalert.bsky.social

Interesting #GIonc read on #IO in #crcsm with #ctDNA 🩸🧬

#ctDNA helps detects #MRD for #dMMR stage III #crcsm it can guide treatment shifts:
ineffective chemo ➡️ #immunotherapy 🟰 ⬆️ outcomes

🔗: www.tandfonline.com/doi/full/10....

What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...

Hi add me there