Paul Huggan

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Whaaingaroa whaanau hoe. Picture’s worth 1000 words.

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Dr. Anthony Fauci urges Americans not to accept "Normalization of Untruths".

The first #Communicable & #Breakpoints collaboration episode drops Mon 5 May! Hosts @angelahuttner.bsky.social
& @erinmccreary.bsky.social interview SNAP trial investigators, @steventong.bsky.social & Joshua Davis, on the results shared at #ESCMIDGlobal 2025. #IDSky #clinmicro
@sidpharm.bsky.social

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📉 Political decisions threaten academic freedom & data access in science. US policy changes impact global health funding & communication, risking healthcare equity & infectious disease response.

#idsky

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Also very low mortality (<5%) in the confirmed bacterial infection group. Crude mortality in our red flag sepsis cohort is around 20%.

In a study of 600 patients with sepsis, mortality amongst patients with suspected bacterial sepsis was only 4.5%, meaning they probably didn’t have sepsis. Will need to read the full text on this one.

Pretty unfair to criticize broad spectrum antibiotic use in retrospect- you go broad if you don’t have investigations/micro. US problem seems to be defaulting to pseudo and MRSA cover up front. Similar rates of resistance here but we recommend fluclox/gent’ for undifferentiated sepsis.

Dr Joshua Davis presents data on Cefazolin vs (Flu)cloxacillin for MSSA.

1. Cefazolin is non-inferior.
2. Less AKI with Cefazolin.
#ESCMIDGlobal

Novel outbreak of (x) related to French Horn mouthpiece sharing at Infectious Disease conference. Vienna, 2025.

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

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A multi-site, international laboratory study to assess the performance of penicillin susceptibility testing of Staphylococcus aureus There is clinical uncertainty over the optimal treatment for penicillin-susceptible Staphylococcus aureus (PSSA) infections. Furthermore, there is concern that phenotypic penicillin susceptibility tes...

13%–57% of invasive S.aureus isolates. Labs need to be confident with manual testing. pmc.ncbi.nlm.nih.gov/articles/PMC...

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The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries The recent Editorial by The Lancet Microbe, titled Rethinking blood culture, highlights the blood culture bottle shortage in the USA and the overreliance on single manufacturers.1 The shortages of blo...

If you can't afford to use a diagnostic test, then its relative performance characteristics become irrelevant.

Important issue raised re blood cultures 👇 @lancetmicrobe.bsky.social
#ClinMicro #IDSky #AMR
www.thelancet.com/journals/lan...

This is utterly horrific. The person who will be conducting the wasteful HHS study of the nonexistent link between vaccines and autism is David Geier. This man is a fraud, having been disciplined for practicing medicine without a license a decade ago. You’ve probably never heard of him, but he and…

I am thankful to people like you who lay it on the line when things are wrong. This whole administration is beyond mediocre--it is dreadful.

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A lot of global academic conferencing is centered around the US, and US academic orgs have to be thinking very seriously now. You cannot continue to carry on with in person conferencing as if foreign scholars have no impediments to travel.
I know we like to pretend everything is "normal" again but..