Karreth Lab

From the biology on melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 to learn the latest in the pigment cell field (and escape the cold) at the Annual Meeting of the Pan-American Society for Pigment Cell Research

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma Chadourne et al. identify CDH3-AS1 as a downregulated antisense RNA in melanoma that enhances P-cadherin translation through a SINEUP-like mechanism. CDH3-AS1 overexpression suppresses melanoma growth...

Interested in anti sense #RNA functions and their contribution to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports www.cell.com/cell-reports...

taste of science An event series and festival for grown ups in your favorite places. Come feed your curiosity!

Maybe there are some ideas here: tasteofscience.org

Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Yes. 6th percentile. I haven't given up hope, council is next month. But I've already submitted it as a new app again

With the NCI payline lowered to 4th percentile, this unfortunately did not age well

Fundable R01 score 🥳

Another preprint from our group. Here we show that FRA1 is a potent driver of #melanoma metastasis and inhibiting some of FRA1's transcriptional targets diminishes dissemination

Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity

Indeed, fucked we are

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

Gave a talk at the University of Louisville a few weeks ago and received this thank you gift in the mail today. My first Louisville Slugger - so cool!

We wrapped up our final day of #AMC25 on Saturday!
Four days of insightful discussions, collaboration, & cutting-edge research. Grateful to everyone who joined us in DR to share insights, engage in conversations & foster collaborations. Until next time!🐭☀️🌴

Not far at all! If you're down here and tired of cooking lemme know and Gina and I will take you to dinner

I much prefer looking at food pics than reading the news these days, so thank you 😁

I’ll be in DC March 7th at the StandUpForScience rally. See you there! If you can’t make it to DC there will be a StandUpForScience rally in a city near you. @standupforscience.bsky.social

Aren't mice obligated nasal breathers? How would CPR work in that case?

Anyone else use 'please' and 'thank you' when entering AI prompts? I hope my life will be spared when AI takes over...

Some study sections seemed to have happened this week - one ND (R01) and a 7%ile (R21). But are June council meetings going to be on?

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

4 papers submitted - a busy start to the year. Let's hope 2025 won't be the year of rejections 😁

More work is needed, but asRNA appear to be key regulators of mRNA translation, potentially to deal with secondary structures in the mRNA 5'UTRs.

Ribosome profiling confirmed the effects of CDH3-AS1 on P-cad translation but also uncovered a global effect of asRNAs: transcripts, especially those with longer 5'UTR, that have an asRNA overlapping with the 5'UTR, are translated more efficiently.

CDH3-AS1 increases P-cadherin without affecting CDH3 transcription, splicing, localization, or stability. CDH3 harbors secondary structures in its 5'region that reduce translation. CDH3-AS1 overlaps with this region and enhances P-cadherin translation.

Like CDH3, CDH3-AS1 acts as a tumor suppressor, and we show the TS effects of CDH3-AS1 require CDH3/P-cadherin expression. CDH3-AS1 interacts with CDH3, preferntially when expressed in cis from a common locus.

We profiled deregulated noncoding RNAs in melanoma cells and found hundreds of asRNAs. CDH3-AS1, the most downregulated asRNA, overlaps CDH3, which encodes P-cadherin and which is also robustly reduced in melanoma. Both CDH3-AS1 and CDH3 are suppressed my MAPK signaling.

New preprint from the lab just posted to bioRxiv. Our first foray into antisense RNAs, led by postdoc Manon Chadourne, with implications for mRNA translation. Great collab with Alex Jaeger and his lab!

We are recruiting a postdoc to join our team (myself, Boris Bastian, and Iwei Yeh) at UCSF to develop a pre-cancer atlas of skin cancer -- part of the Human Tumor Atlas Network (#HTAN). #CancerEvolution #Bioinformatics. Interested? Email resume and cover letter to me.