IVDP-Hamburg

Utilization and Costs of Laboratory Monitoring in Biological and Non-Biological Psoriasis Treatment - Large-Scale Claims Data Analysis - PubMed Biologic therapies for psoriasis induce considerably higher monitoring costs than non-biological systemic drugs. Age and CCI were main predictors for higher utilization of laboratory services, indicat...

🎯In 8,018 people with #psoriasis, biologic therapies required higher lab monitoring costs driven by age and comorbidities, yet these remain low relative to drug expenses. Initiation at specialized centers involves costly tests, while follow-up is far cheaper.

👉 pubmed.ncbi.nlm.nih.gov/40785802/

Burden of Disease in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Scoping Review - Applied Health Economics and Health Policy Objective Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious chronic and complex multi-system disease characterised by symptoms such as post-exertional malaise, fatigue, cognitive impairment and pain. Diagnosis is based on international consensus criteria, and no curative treatment is available. In the USA, its prevalence is estimated at 0.42% among adults, with women affected three times as often as men. Prevalence is expected to increase due to the COVID-19 pandemic. In addition to its severe symptoms, ME/CFS has a substantial economic impact. This scoping review aimed to systematically examine the global health, social and economic burden of ME/CFS. Methods We conducted a systematic literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) guidelines in six databases and supplemented it with a citation search. We assessed study quality using a modified version of the Mixed Methods Appraisal Tool. Results We included 20 studies that assessed costs (n = 16), disability-adjusted life years (DALYs) (n = 3), employment rates (n = 1), and school attendance (n = 1) as indicators of disease burden. Reported costs per patient ranged from USD 2,916 to USD 119,611, with indirect costs accounting for the largest proportion. DALYs reported for the USA ranged from 0.714 million in 2016 to 5.77 million in 2022. Conclusion ME/CFS imposes a substantial health, social and economic burden of disease. Discrepancies in estimates are probably due to differences in study samples, methodologies, cost components, and healthcare systems. Because ME/CFS is assumed to be underdiagnosed, its true burden may be even higher.

Our new systematic review shows that #MEcfs has significant economic consequences. None of the studies describe how many severely ill patients were included – probably very few. Therefore, the studies are likely to underestimate the burden.
link.springer.com/article/10.1...

How to Interpret Quality of Life Assessment of Patients With Chronic Wounds Using the Wound-QoL - PubMed The Wound-QoL assesses patients' health-related quality of life. Quick and valid interpretation of the results is crucial, but no thresholds have yet been established. Additionally, counting top box r...

New guidance on interpreting quality of life data in wound care!
We present:
👉 thresholds for the Wound-QoL questionnaire
👉 a quick-and-easy way to determine scores by counting top-box responses
🔗 pubmed.ncbi.nlm.nih.gov/40898606/

#wounds #ChronicWounds #HRQoL #QoL

@blomechristine.bsky.social

Are Systemic Drug Choices for Psoriasis by Dermatologists Compatible with Psoriatic Arthritis? Data from the German National Psoriasis Registry PsoBest - PubMed Early and effective treatment of PsA is crucial to prevent persistent damage of the joints. Although most patients received recommended systemic treatment for PSO+PsA, there is a small number of patie...

In Germany over 90% of patients with psoriatic arthritis received appropriate agents by dermatologists. Our analysis of 17,310 patients from the national psoriasis registry PsoBest underscores the need for targeted therapies addressing the systemic inflammation.
📌 pubmed.ncbi.nlm.nih.gov/40463331/

Exploring the relationship between dietary factors and structural brain alterations in a partial least squares correlation analysis - PubMed Across all dietary patterns, vegetables and fruits were the food groups with consistent associations with preserved brain structure, indicating the importance of these foods for neurological health. T...

How does diet affect brain structure?
📌In a cohort conducted by the HCHS of 2652 adults, higher intake of vegetables, fruits and whole grains was linked to a healthier brain structure. The MIND diet, which focusses on brain health, showed the strongest association. pubmed.ncbi.nlm.nih.gov/40683131/

Patient-reported well-being in value-based care using tildrakizumab in a real-world setting: protocol of a multinational, phase IV, 1-cohort prospective observational study (the POSITIVE study) - PubM... ClinicalTrials.gov Identifier: NCT04823247 (Pre-results).

How does tildrakizumab impact the well-being of people with #psoriasis and their families?
The POSITIVE study gathered real-world evidence in 9 European countries, showing its successful contribution to value-based long-term care for moderate-to-severe psoriasis.

pubmed.ncbi.nlm.nih.gov/36792337/

Evolution of Drug Supply for Psoriasis from 2010 to 2022 - Real-World Claims Data Analysis in Germany - PubMed In more than a decade, the use of innovative systemic drugs, especially biologicals, in Germany has increased substantially. Despite their high cost, biologic expenses per person have slightly decreas...

How has #psoriasis treatment changed for people living with the condition in Germany?
Between 2010–2022, biological agent use rose by 450%❗, while per-person costs declined slightly. This shows how new treatments continue to reshape long-term psoriasis care.

👉 pubmed.ncbi.nlm.nih.gov/40600112/

Our new mixed-methods study reveals major barriers to #healthcare for patients with #alopecia areata in Germany: lack of reimbursement, limited access to systemic treatment, and gender and regional disparities.

Read our recommendations for action here:
👉 pubmed.ncbi.nlm.nih.gov/40447440/

Benefits and Satisfaction with Apremilast Treatment in Patients with Psoriasis Affecting the Genital Area: Secondary Analysis of the APPRECIATE Study - PubMed The APPRECIATE study was registered at https://clinicaltrials.gov/ with the number NCT02740218.

🔬 APPRECIATE study: A real-world analysis of #psoriasis patients evaluated the effects of apremilast, a phosphodiesterase-4 inhibitor, including those with genital involvement.
📌 Results showed improvements in disease severity and #QoL gains across all groups.

pubmed.ncbi.nlm.nih.gov/39969771/

Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report - PubMed Linear psoriasis (LP) represents a rare variant of psoriasis. The clinical presentation includes erythematous plaques distributed along the Blaschko lines, reflecting the presence of embryological mos...

📝A recent case report describes the use of Ixekizumab, an IL-17A antagonist, in a patient with linear #psoriasis. The patient showed major improvement over 16 weeks. It highlights histological confirmation and explores IL-17 blockade as a therapeutic approach.

pubmed.ncbi.nlm.nih.gov/39866910/

[Effects of high thermal stress on health-a nationwide analysis based on statutory health insurance routine data between 2012 and 2021] - PubMed The article shows that associations between thermal stress and morbidity can also be found in routine SHI data. Against the background of an increase in high thermal stress due to climate change, this...

👉💡New study links rising temperatures with increased heat-related #health issues in Germany. An analysis of health insurance data (2012-2021) shows Heat-related diagnosis spike in hotter months, highlighting urgent need for adaptation measures.
📌 #Climate #Heat

👉 pubmed.ncbi.nlm.nih.gov/39446174/

Patient-reported outcome measures for post-COVID-19 condition: a systematic review of instruments and measurement properties - PubMed CRD42023391238.

📝👉Measuring the #patient perspective in Long COVID!

👏Many thanks to the Institute of Social Medicine and Health Systems Research in #Magdeburg, for inviting us to participate in this project!
#longcovid #Covid #SARS-CoV-2 #Research

@blomechristine.bsky.social

👉 pubmed.ncbi.nlm.nih.gov/39806627/

Healthcare of patients with atopic dermatitis by general practitioners - a nationwide survey in Germany - PubMed A considerable proportion of patients with AD in GP care shows poor outcomes, as has been observed in dermatological care - possibly due to the lack of use of modern systemic therapy.

📌📝A study (2019-2021) with patients diagnosed with atopic dermatitis and undergoing GP treatment reveals that many patients experience poor outcomes. This could be due to both the rare use of modern therapies and the lack of participation in training programmes.
👉 pubmed.ncbi.nlm.nih.gov/39226528/

Palmate Erythema With Pruritus Following Contact With Lime Juice, a Variant of "Margarita Photodermatitis" - PubMed Palmate Erythema With Pruritus Following Contact With Lime Juice, a Variant of "Margarita Photodermatitis"

👉Lime-induced phytophotodermatitis, triggered by lime juice and sun exposure, presents with #erythema, #pruritis, and #bullae. In our case report, despite treatment, residual hyperpigmentation persisted, emphasizing the importance of recognizing sensitizing agents.
pubmed.ncbi.nlm.nih.gov/39673137/

Systemic Therapy of Psoriasis in Children-Proposal of an Algorithm for Interdisciplinary Teamwork - PubMed <span><b>Background/Objectives:</b> Children and adolescents with psoriasis can have severe and long-lasting disease requiring early and effective therapy. The range of associated comorbidities is com...

👉 Children with #psoriasis have different needs and less options for medical therapies than adults. Close #collaboration with pediatricians and other specialties for systemic therapies are crucial for a well-managed #health care and compliance. pubmed.ncbi.nlm.nih.gov/39518448/
#PediatricPsoriasis

👏📊Prof. Dr. Kristian Reich has earned the title of Highly Cited Researcher by #Clarivate_Analytics, ranking him among the top 1% of his field from 2013 to 2023. His influential research on inflammatory #skin diseases and emerging treatment strategies is driving innovation in #dermatological #care.💪

Preferences of melanoma patients to accept adjuvant therapy and toxicity - a qualitative substudy of the GerMelaTox-A project - PubMed Patients in our study indicate high willingness to undergo adjuvant therapy, even when facing toxicity. The evaluation of potential side effects and prospects of treatment benefit is highly individual...

Preferences of patients with #malignant_melanoma to accept adjuvant therapy are based on treatment efficacy, side effects, and quality of life. Personalised approaches are essential for shared #decision-making.
👇🏽📄
pubmed.ncbi.nlm.nih.gov/39627632/

🔍Wissenschaftliche:r Angestellte:r Junior (all genders) – Schwerpunkt "Statistik und Methodik" am UKE gesucht! 🔍

Werden Sie Teil unseres Teams!
👉 Bewerben Sie sich bis 27.01.2025!
👉 Details: uke.jobs/3961.

👉 #New: We developed and validated the Patient Benefit Index (PBI) for #Epilepsy - a novel tool measuring patients’ need, treatment benefits and challenges in epilepsy #care.
👉🏻📝 pubmed.ncbi.nlm.nih.gov/39612628/

Need for individualized counseling regarding psoriasis systemic therapy in women of childbearing age: analysis of the PsoFem study at the University Medical Center Hamburg - PubMed For WoCBA with childbearing wishes, tumor necrosis factor alpha blockers were most frequently prescribed, in accordance with current guidelines/recommendations. Decision-making for continuing or chang...

👉🏼Managing moderate-to-severe #psoriasis in women planning #pregnancy is challenging. Our study shows that TNF-alpha blockers are more often chosen following guidelines for treatment. Family planning needs communication between patient and doctor for decision-making. pubmed.ncbi.nlm.nih.gov/39555230/

Epidemiology and Healthcare of Juvenile and Late-Onset Acne: Claims Data Analysis - PubMed Acne affects a relevant proportion of the German population not only in adolescence, and management of this inflammatory skin disease does not naturally follow medical guidelines or specialist recomme...

👉🏻📊Our large-scale data on late-onset #acne (acne tarda) in #Germany shows a relevant prevalence after adolescence, in particular in #women, resulting in about 950,000 involved. Specialised knowledge and health care for acne tarda and its comorbidities is needed📝
pubmed.ncbi.nlm.nih.gov/39422854/

Predictors and mechanisms of self-stigma in five chronic skin diseases: A systematic review - PubMed Findings from the present review revealed several psychosocial variables that are malleable and potentially suitable as intervention targets. Those variables such as acceptance should be targeted in e...

📝People with visible skin conditions like #dermatitis, #psoriasis, #vitiligo, and #alopecia often face social and self-stigma. A new review explores factors behind this burden and highlights targets for psychosocial interventions.
#HealthAwareness 📄👇🏻
pubmed.ncbi.nlm.nih.gov/39247975/