Blue feeding experimental device with nose poke clogged

@kravitzlab.com 😭😭 this is the active port, luckily there is evidence of pellets having been dispensed overnight. The inactive port was clear of bedding.

Hippocampal ensembles regulate circuit-induced relapse of extinguished fear Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear

🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Why are women twice as likely to get Alzheimer’s disease? Explore the complexities of Alzheimer's disease and its disproportionate impact on women, influenced by hormonal and societal factors.

Fantastic new article by Dr. Christy Niemeyer on the disproportionate burden of Alzheimer's disease on women. @csniemeyerphd.bsky.social

sciencerabbit.org/2025/04/04/w...

Opinion | The Tech Fantasy That Powers A.I. Is Running on Fumes (Gift Article) A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.

This piece from @tressiemcphd.bsky.social starts with a bang and just gets better and better. Gift link.

Amid NIH upheaval, how to keep sex as a biological variable Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.

I wrote a piece for @thetransmitter.bsky.social www.thetransmitter.org/sex-differen... With the fate of NIH-funded research uncertain, it is extra important that the work we do now is most likely to benefit everyone. Adhering to SABV in the lab and in grant & paper review is the right thing to do.

@aoc.bsky.social and @sanders.senate.gov anti-oligarchy rally in Denver, CO!

Thank you @sanders.senate.gov and @aoc.bsky.social for rallying us together, and not dividing us apart! #denver #fightoligarchy

New review from the lab!
Do #microglia metabolize #fructose in #Alzheimers Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻‍🔬💪🏻

Why would a commercial software use 0's for missing values????

More than ever we need to talk about the importance of our "basic research" in public and political forums. Kudos to #AnnaliseSturno and @neurohassell.bsky.social for getting out there and sharing their work on fructose metabolism and Alzheimers Disease at #Denver #Capitol

Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social

Title of the brochure is STEM poster day at the capitol. Text below reads, Colorado scientists will be presenting their research to legislators and members of the public. The event is open to everyone, and we invite you to atrend! When, March 11th, 2025 9:30 am- 12:00 pm, where, Colorado state capitol, wedt foyer, who, ooen to the public!

@lindseyforco.bsky.social & @shannonbird4co.bsky.social I live in y'alls district and will be talking about the link between sugar on the 🧠 and Alzheimer's in @drkimberleybruce.bsky.social 's lab at @cuanschutz.bsky.social with @projbridgeco.bsky.social. Hope to see y'all there!

I continue to be blown away by the sub-cellular resolution that our new #Nanolive 3D explorer allows. Look at these #microglia go!

Flyer for stand up for science--more information available at www.standupforscience2025.org

TODAY IS THE DAY! 🧪☀️⬇️

Join us at the Lincoln Memorial or your local site to Stand Up for Science!

Your lab scissors are actually a parafilmase - a highly specialized enzyme that catalyzes the precise cutting of parafilm through a metal-dependent mechanism

Join our monthly Getting Started on the OSF webinar every 2nd Monday at 11 AM ET!

Learn how OSF supports open science and streamlines research workflows

🌟 Highlights:
✔ Guided feature tour
✔ Use case exploration
✔ Live Q&A

🔗 Register: cos-io.zoom.us/webin...

A Black woman named Aliyah was struggling to find work. So, she catfished herself and made a fake profile on LinkedIn named "Emily." Emily had the same qualifications as Aliyah but received 57.9% of interview invites while Aliyah received 8.9%

This is what we mean when we say racism is systemic.

Purple PCB laying on black bench top facing up. FED3.1 version 7.1. Solder and resistors in background.

I think I finally got the hang of surface mount resistors. Version 7.1 is a different piecing together project for sure.

Blue circuit board sitting atop a lab bench. Showing the back side of the board with the resistors poking through.

Back at it again! @csniemeyerphd.bsky.social @kravitzlab.com

The ATP sensor looks super cool! Thanks for the heads up!

Yes! Could I also get the recipe?

Really cool work! I wonder if the BLA-Nac projectors were feed-forward inhibiting or stimulating Nac. Same with CeA. Also wonder if this is restraint specific or if other stressor modalities would piggy back this same circuit? Thinking Pacak Palkovits 2001.

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...

I have done a rhodamine Phalloidin stain on cultured microglia without perm and have had success. Though recently it has been inconsistent and have been down a rabbit hole as to why it even works in the first place. I switched to glyoxal fixation and it doesn’t work at all.

Question for science Bluesky. Does 4% PFA during cell fixation permeabilize cell membranes?

Nature paper article with title and abstract

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)

Read it here: www.nature.com/articles/s41...

Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain

#CUAnschutz researchers are among the first to recognize how Herpes simplex virus type 1 infiltrates the brain, leading to a better understanding of how it may trigger neurological diseases. The study was recently published in the Journal of Virology. ⬇️🧠

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…

xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...

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