David Y.T. Chen

@ascocancer.bsky.social #GU26 Day 3–it’s kidney day!

K-M curves of ctDNA result

K-M curves of ctDNA as dynamic biomarker

ctDNA predicts extravesical not local disease

Summary of conclusions

@ascocancer.bsky.social #GU26 the key findings:
#blcsm

Dr. Ghatalia giving talk of LBA at general session

The protocol schema for ph2 single-arm RETAIN-2 trial

@ascocancer.bsky.social A major late breaking abstract from Fox Chase: ctDNA informing outcome and prognosis for MIBC post-NAT and is a key parameter for risk-adapted management
An amazing presentation by Dr. Ghatalia, worth reviewing the recording again
#blcsm

Recurrence following EV/P v Cis/Gem

OS results for EV/P v Cis/Gem

#GU26 @ascocancer.bsky.social
Keynote-B15 results—significantly improves RFS/OS compared to Gem/Cis
#blcsm

Galsky at the podium at GU ASCO Day 2

Keynote-B15 Protocol schema

Protocol pathway and results

#GU26 @ascocancer.bsky.social
Starting off with practice changing presentation of Keynote-B15:

Galsky reporting the unprecedented response surpassing Cis-Platin for NeoAdjuvant Treatment, this will cement EV/P as SOC for all MIBC
#blcsm

#ASCO #GU26
Day 2 —it’s urothelial cancer day!
#UroSome

#ASCO #GU26
Barocas highlights idea of
Regret=Expectations - Outcome

Probably more accurate to be in the opposite order:
Regret=Outcome - Expectations

➡️when expectations are higher than outcome, regret is a net negative result

Figure of functional change after treatment, between open RP and 2-D RT. https://www.nejm.org/doi/full/10.1056/NEJMoa1209978

#ASCO #GU26
Session on localized #ProstateCancer
Dr. Ron Chen highlights functional impacts, comparing RP v RT
*Emphasizes for PCOS that was much less sophisticated radiation

I would add that was much less sophisticated surgery (open RRP) #pcsm

#ASCO #GU26
You can tell the make up for the meeting’s attendees at the afternoon #prostatecancer general session on localized disease

Lots of empty seats (not a criticism of the speakers)
—Dr. Barocas shows slides on anatomy, not Kaplan-Meyer curves—Not much of a draw if you are a med onc 🤷🏻‍♂️

Find a Prostate Cancer Screening | Relax, It’s a Blood Test The first step in prostate cancer screening could be a simple blood test. Learn more about prostate cancer risk factors and find a screening site near you.

#ASCO #GU26
Re: comment from the audience:
I appreciate the patient advocate sharing he has a new #prostatecancer diagnosis stemming from his getting a #PSA spurred by the Super Bowl Ad!
#ScreeningSavesLives

www.relaxitsabloodtest.com?site=GK10010...
#pcsm

a man in a suit and tie is smoking a cigarette while sitting at a table . ALT: a man in a suit and tie is smoking a cigarette while sitting at a table .

🔜 #GU26 @ascocancer.bsky.social

How to approach a vast meeting w/so much data?

Look beyond data that repackages known truths but do NOT really advance understanding

Common examples:

1. Less cancer is better than more cancer

2. Responders do better

3. More treatments vs. less improves PFS

#ASCO #GU26
My comment on POSEIDON
Looking at ADT w/PORT (=post-op RT)
—for adding ADT, it recs apply for PSA >0.5, not PSA <0.5

**As surgeons we shouldn’t be seeing that high a PSA BCR, should get PORT before such “high” levels.

And there is prob benefit for ADT in BCR with very short PSA DT

#ASCO #GU26
Day 1 of the GU cancer symposium in SF—it’s prostate day!

Can confirm

A Cornell urology residency alum presenting the Keynote address for Philly Urologic (PUS)

Two old guys who trained together in urology starting at the end of the last century

Great to see Jaspeet Sandhu @mskcancercenter.bsky.social in town to give the Philadelphia Urologic Society B.A. Thomas lecture—a leader in urology cancer survivorship. Has it really been over 25 yrs since we were at The Brady? #CornellMafia
#UroSoMe #UroSky

Screenshot of the article. Two more royal colleges join the X exodus—why medical leaders are refusing to tweet The RCP and the RCGP are stepping back from Elon Musk’s social media platform, citing abuse and hatred. Three other medical organisations have left, and two are reviewing their activity. Chris Stokel-Walker reports

Second page. Excerpt here: Grok, the AI image generator, brings concerns to a head Once Musk had taken over Twitter and then renamed it X in 2023, he reshaped it by removing guardrails and firing the trust and safety staff who were meant to monitor users’ behaviour and the content posted, to help keep the app a pleasant place. As a result, abuse and harmful content thrived. Things came to a head over Christmas 2025 when users began weaponising X’s AI image generator, Grok, to harass women by posting nude or scantily clothed images of them. Ofcom, the UK’s communications regulator, opened an investigation into the platform after the technology minister, Liz Kendall, raised concerns in parliament. Matt Navarra, a social media expert, says, “I think the royal colleges, operating in tightly regulated sectors like healthcare, can’t afford to be seen sharing space with platforms that are under investigation for failing to prevent harm. And that’s a compliance risk, not just a PR risk.”

From the @bmj.com this week - some commentary on the exodus of medical leaders from X that used to be Twitter.

It’s sad, but I think it’s the right thing to move away from that platform.

#MedSky

Link here:
www.bmj.com/content/392/...

Image of post from that other site giving details on upcoming information open house hosted by the PDs of 3 leading GURS training programs.

FYI—this unique opportunity is next week, to meet PDs of the premier GURS fellowship programs in one setting.

Feb 5–

One Zoom – Don't miss it!

Register: tinyurl.com/Gursopenhouse

@SocietyGURS @urorecon @jsimhan @TempleUrology @FCUroOnc @caseurology #GURS #UrologyFellowship
#UroEd

Hey, let’s get you over here. Maybe double post here and that other place and see if we can increase the traffic to a critical mass. #UroSoMe

Reposting from that other site, the announcement about FCCC virtual open house on our SUO fellowship

Inviting interested candidates to the FCCC Uro Onc fellowship virtual open house
Link here to register:

forms.office.com/pages/respon...
#SurgEd #FCCCProud #PhillysCancerCenter

Temple Urology Residency Program Open House Wednesday 9/3/25, 7-8 PM Eastern time

Link to sign up:

forms.gle/A2TAPpecRuyw...

Announcing an open house information session about the Urology Residency at the Fox Chase-Temple Urologic Institute

Reposting here:
#UroEd #SoMe

Jon Stewart responded to CBS bowing down to Trump and canceling Colbert

AC United Predators —U18 Challenge Cup winners

How it finished:
#EPYSA Challenge Cup winners

Challenge Cup U-18 Finals

Warming up at WSFS fields

Countdown to last game of high school career

Focused Ultrasound Matches Prostatectomy for Intermediate-Risk Prostate Cancer Numerically fewer cases of treatment failure with focal ablation, fewer complications

"We've gone from being a fringe option to being recognized as a level of treatment on par with surgery and radiation." -- @dytcmd.bsky.social, of Fox Chase Cancer Center, discussing focused ultrasound ablation for operable #prostatecancer. #AUA2025
www.medpagetoday.com/meetingcover...

The big moment!

So this just happened!
And congrats to all the grads of Class of 2025!
#ProudDad #GoOwls #CST @temple.edu

Wordle 1,391 1/6*

🟩🟩🟩🟩🟩

This won’t ever happen again

Former FDA Commissioner under Trump 1.0:

@scottgottliebmd.bsky.social

It’s weird* that the president can just decide to put a huge tax on American businesses without congress even being a little bit involved.

* very unconstitutional