Joe Grove

Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄

A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think.

Our at-scale AI structure prediction gave a complementary perspective on viral evolution.

www.nature.com/articles/s41...

National flu and COVID-19 surveillance report: 30 October 2025 (week 44)

Always fun when the word "unusually" turns up in a UKHSA doc: "influenza activity increased, particularly among children, and is now above baseline. This is an unusually early start of the influenza season." www.gov.uk/government/s...

Announcement of the “Expert insights” online seminar series by the ACHIEVE Academy. Talk by Dr. Timothy Soh from the Leibniz Institute of Virology on “AlphaFold & HerpesFolds.” Date: Tuesday, October 7, 2025, at 2:00 PM. The series takes place every first Tuesday of the month.

🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...

Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!

I only just managed it 6 months ago...

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

Viral AlphaFold Database (VAD) is live in Science Advances

~27,000 predicted viral protein monomers & homodimers

Conserved folds across bacteria, archaea & eukaryotic viruses

New toxin–antitoxin system KreTA uncovered

Vast “functional darkness” remains uncharted

www.science.org/doi/10.1126/...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.

Check out this work co-led with @benadler.bsky.social here:

www.nature.com/articles/s41...

A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3 Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...

New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab!

We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!

A plastic sign with a logogram of two people in conversation alongisde text that reads "There are no lone geniuses"

Our new "There are no lone geniuses" sign mounted on the door to the lab.

I made a sign for the lab with our informal lab motto, inspired by this convo between @itaiyanai.bsky.social and Martin Lercher: nightscience.buzzsprout.com/1744020/epis.... A good reminder that talking is among the best forms of thinking!

These 99 'lab hacks' will make your scientific work easier Nature asked contributors, editors and working researchers to share their best advice for scientists.

Over the last year, Nature’s Careers team has been tapping into its global community of readers, writers, friends and colleagues to compile a list of laboratory hacks to help make scientists’ working lives easier. Here’s a list of 99 of those hacks. #Academicsky 🧪

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬

Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social

www.embopress.org/doi/full/10....

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

www.embopress.org/doi/full/10....

PhD position in my team!

Join me in the new Graduate School ACME (www.mhh.de/en/institute...). 65% TVL 13 for 4 years integrated into the Hannover Medical School; the ACME program starts in April 2026, but joining us earlier is possible.
1/3

@gesvirologie.bsky.social
@infect-net.bsky.social

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

AussiERV 2025 AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!

Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔

Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️

Abstracts due 1st October!

events.humanitix.com/aussierv-2025

#ERV #retrovirus

Congratulations to @ulad-litvin.bsky.social for this! He performed the vast majority of data curation and analysis, made the majority of figures for the manuscript AND drafted the text. An AMAZING effort!

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵

📑 Paper doi.org/10.1038/s443...
🔭 Explore virosphere viro3d.cvr.gla.ac.uk

Researchers launch world’s most comprehensive human virus protein database A look at new Foundation-funded research by Dr Joe Grove and his team at the MRC-University of Glasgow Centre for Virus Research.

Our ELP winner @grovearmada.bsky.social and his team have launched Viro3D, an AI-powered virus protein database, which will help scientists understand and combat emerging viral threats more efficiently.

Read more here: https://bit.ly/3IIfND1

@cvrinfo.bsky.social @uofglasgow.bsky.social

Team effort from @uofgmvls.bsky.social @cvrinfo.bsky.social

Science: @ulad-litvin.bsky.social @spyroslytras.bsky.social @davidlrobertson.bsky.social and @bljog.bsky.social

Website: Alexander Jack

Funding: @medresfdn.bsky.social @ukri.org @wellcometrust.bsky.social @royalsociety.org

THIS RESOURCE WILL ACCELERATE:

🔬 Discovery in molecular virology

🧬 Studies of virus origins and evolution

💊 Structure-informed vaccine/therapy design

viro3d.cvr.gla.ac.uk - feedback welcome as we continue developing Viro3D!

Protein structures of class-I fusion proteins, color coded by structural conservation

KEY DISCOVERIES:

🗺️ Mapped evolutionary relationships across the virosphere

🔍 Found unexpected class-I fusion glycoproteins in herpesviruses

🧬 Revealed potential origins of coronavirus spike proteins through ancient genetic exchange

Paper: www.embopress.org/doi/full/10....

WHY THIS MATTERS:

🦠 Viruses are underrepresented in existing protein structure databases such as the PDB and AlphaFold Database

🤖 We combined AlphaFold2-ColabFold and ESMFold to predict proteome level structures for >4,400 human & animal viruses

💻 Searchable and browsable at: viro3d.cvr.gla.ac.uk

🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.

🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....

@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠

iFold, sorry, SimpleFold, by Apple

arxiv.org/html/2509.18...

Thank you Sis ❤️. I could watch (through my fingers and without company of other humans).

See our ELP winner Dr Joe Grove discussing his work with Dr Chris van Tulleken at 9pm tonight on BBC2, or right now on BBC iPlayer: bbc.in/47WjAXM

Joe and his team at @cvrinfo.bsky.social @uofglasgow.bsky.social are using #AI to better understand how viruses evolve and function.

Three jobs in our shiny new building:

Check out this new BBC documentary on Disease X and pandemic preparedness, broadcast tonight (22/09) and on BBC iPlayer.

It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖

It was a real pleasure working with Chris VT and the team. Thank you!

Meet us at Genopolys , Montpellier for a France-Japan virology workshop ! 9-10 october 2025 ! 2 exciting days with many viruses! Co-organized with @systemsvirology.bsky.social Kei Sato and Monsef Benkirane @igmm-montpel.bsky.social @cnrsbiologie.bsky.social @umontpellier.bsky.social

GPU-accelerated homology search with MMseqs2 - Nature Methods Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com