NIK-OI 🦬

📝 A new Nature study from Lippincott-Schwartz group at Howard Hughes Medical Institute reveals that secretome mRNAs are translated at specialized sites.

🔎 This uncovers a new spatial layer in how cells make secreted proteins with broad implications.

📖 Read more: https://go.nature.com/43zRK0t

From MBoC: Wallace F. Marshall (UCSF) and team profile the giant ciliate Stentor pyriformis—symbiotic algae in microtubule baskets, symbiont-dependent phototaxis, and a standard genetic code. Paper: www.molbiolcell.org/doi/10.1091/... #CellBiology

Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7

The Research Council of Finland funds cutting edge research at Åbo Akademi University with €4.5 million Researchers at Åbo Akademi University have been granted nearly €4.5 million by the Research Council of Finland. The funding supports high-level research in fields such as cancer biology…

Delighted to start my next scientific adventure with Cecilia, Kari and Taija looking at lymphatic immune interfaces. Many thanks to the research council of Finland to fund our Center of Excellence www.abo.fi/en/news/the-...

Fall in Corrèze

Tomorrow Wednesday 29th at 11am, lesson #3 of @neilshubin.bsky.social guest Professor @college-de-france.fr on ‘The evolutionary origin of bones and teeth’. The second lesson is available @ www.youtube.com/watch?v=0B6y... . No registration, Free access, dentures accepted.

Image captured at 4X on a fluorescence microscope showing a tissue section through the mouse prefrontal cortex where neurons that project to the locus coeruleus in the brainstem are virally labeled in red and neurons that are activated are labeled with Fos in green.

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem

www.nature.com/articles/s41...

Tenure-track Position in Biophysics at Carnegie Mellon University, Department of Physics Location: Pittsburgh, PA Open Date: Sep 19, 2025 Description The Department of Physics at Carnegie Mellon University invites applications for a tenure-track faculty position in biophysics. The appointment is intended to be at the Assistant Professor level, but exceptional candidates at a higher level may also be considered. We seek outstanding candidates with a strong record in cellular and subcellular biophysics. Topics of particular interest include, but are not limited to, uncovering how key characteristics of living systems arise from the interplay between supramolecular cellular structures, how the emergent cellular circuitry defines goals and enables robust decision making, and how metabolic resources are allocated. This encompasses understanding of how information is learned, stored, transduced, and processed across subcellular structures. Applicants with theoretical, data science, or experimental backgrounds within biological physics are encouraged to apply. The ideal candidate will strengthen and extend research programs of current biophysics faculty in the Department of Physics and collaborate with broader life science activities across many departments at CMU and the wider Pittsburgh area. More details on Interfolio: https://apply.interfolio.com/174360

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪

Interfolio link: apply.interfolio.com/174360

PLEASE, share widely across the blue skies!

Let me briefly explain what we're looking for:

1/10

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

A restricted subset of gut-innervating neurons that express the neuropeptide myosuppressin (Ms) innervate the crop, a stomach-like structure of the fly intestine. This figure shows co-expression between the Ms protein reporter (green) and Ms peptide (red) in the nervous system, and in neuronal projections towards the gut (blue).

If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025

This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field 💪

🎉 Our discovery opens up exciting new research avenues for supporting healthy brain aging, and treating other metabolic brain disorders. 3/3 #raredisease #mitochondria #neuronalenergy #fattyacids #beta-oxidation #HSP #SPG #metabolism #lipids

💊 Loss of DDHD2-fatty acid pathway causes hereditary spastic paraplegia (HSP54), a childhood-onset neurodegenerative disorder. Excitingly, we found that a combination of activated fatty acids restored neuronal energy and function in HSP54-model neurons, identifying a potential therapy for HSP54. 2/3

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻 #neuron #energy #metabolism #fattyacid #raredisease #HSP #mitochondria #betaoxidation #brain #health #neurodegeneration Read more here: rdcu.be/eIQA0 🧠 🔬

The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université) This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...

Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...

Feeding Frenzy: Protein syntaxin-2 regulates phagocytosis (gobbling up & ingesting waste material) by macrophages

📷 Suman Samanta et al, Indian Institute of Science Education and Research Kolkata in
@jcellsci.bsky.social

➡️ bpod.org.uk/archive/2025... with Lux Fatimathas

Image showing three covers of Journal of Cell Science

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social)
that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more.
For details, visit: journals.biologists.com/jcs/pages/re...

🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

Chicken balancing for #3DThursday!🐔 These utricle hair cells sense gravity & straight-line motion. We segmented them with #CellposeSAM in #syGlass.

🥼: Stefan Heller Group
🏛️: Stanford @stanfordmedicine.bsky.social
🎬: syGlass.io v2.4.0, out now!

#Neuroanatomy #Microscopy #3DVisualization #SciComm

Yesterday I collected some samples from a local Texas pond and was happy to see a bunch of Nauptili. I thought y'all might appreciate this video of one of them -- apologies for a messy condenser --- that gets cleaned this weekend!

#microscope #Iteachbiology #edusky #nature #microscopy #Science

Trying the @zeiss-microscopy.bsky.social LSM 980 with lightfield at my core. I’m very curious about the performance of the lightfield 👀

#microscopy #bioimaging

We're thrilled to announce our participation in the World Expo 2025 in Osaka, Japan! 🎉🗾 With our collaboration partner Magnificent Matter, we are ready to blend the worlds of science and art in a performance at the German Pavilion next week.
#WorldExpo2025 #Osaka #GermanPavilion #TheInvisibleMatters

Microtubules (orange; α-tubulin) and nuclei (blue; DAPI) are shown in two adipocytes, imaged by confocal microscopy.

For #FluorescenceFriday, microtubule networks are shown in two adipocytes 🔬 #CellBiology #Microscopy

🔬 What can the #CrestOptics X-Light V3 #SpinningDisk #Confocal or DeepSIM #SuperResolution #SIM system do for your imaging?

🧠 This image compares widefield, the X-Light V3, and DeepSIM for imaging of a mouse hippocampal coronal section.

🔗 Learn more: bit.ly/3JEOiu6

#NikonMicroscopy #Microscopy

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.