Shefali

Finding Fruit in Flies: Therapy for rare diseases #MetabolismMondays - the Node Emerging perspectives in metabolism. This week we’ll meet Dr. Holly Thorpe.

On this #raredisease day sharing some amazing work done in #Drosophila uncovering genetic modifiers and therapeutic targets for rare diseases from @clementychow.bsky.social lab @uofubiochem.bsky.social

@the-node.bsky.social

Today is #rarediseaseday and in the @araujolabub.bsky.social @geneticsub.bsky.social @biologiaub.bsky.social @ibub-ub.bsky.social we’re using Drosophila melanogaster as a powerful model to study rare diseases.
Small flies, big insights! 🪰#RareDiseaseResearch #Drosophila #Science

Is there a relationship between kinship in parents and aging?

New research in #GENETICS describes the influence of parental kinship on global methylation and #epigenetic age, which may decelerate aging in #deermice offspring. 🐁
buff.ly/PK2h2bk

a woman says " i cannot relax at all " while wearing a black shirt ALT: a woman says " i cannot relax at all " while wearing a black shirt

Saturday morning be like -

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation - Nature Communications During morphogenesis patterned contractility drives tissue shape changes. Here they show that GPCR signaling and integrin activation give rise to a dynamically translocating gradient of contractility ...

New paper out! In this project, we focused on the question how tissue mechanics is spatially controlled during development. We show that the GPCR ligand Fog acts as a “mechanogen” during Drosophila gastrulation, driving a self-organized wave of tissue invagination:
www.nature.com/articles/s41...

@annaryba.bsky.social's paper on the neural underpinnings of intraspecific behavioral variation is now out in @currentbiology.bsky.social

Highly recommend! -> Paper identifies neural substrate for variation in promiscuity among Drosophila melanogaster strains🧪

www.sciencedirect.com/science/arti...

🥹🥹🥹

ShineGAL4 FLP-out clones

#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social

@dev-journal.bsky.social
tinyurl.com/4jpw9jd6

This initiative could not have been possible without the support of current and past #Flyboard presidents @lucksmith.bsky.social, Sally Horne-badovinac and @harmitmalik.bsky.social. Huge thanks to @genetics-gsa.bsky.social for all the program advertising emails 😊

See you all at #Dros26

(4/n)

Huge shout out to the #FlyCROSS committee chaired by me and Laurel Raftery; and our current committee members including @shyama13.bsky.social @jocmcdonald.bsky.social @frankmac.bsky.social @armstrongflylab.bsky.social and Jonathan Andrews - who all have put in tremendous amount of work. (3/n)

We had a total of 122 mentors who volunteered for this cycle including #posdocs, #pretenure #faculty. Below are the mentor demographics and their response summary. We are beyond grateful to the mentors for their commitment and participation. (2/n)

#Drosophila #FlyCROSS 2025-26 updates -
84 mentor-mentee matches were made ✅
Out of which 90 % of mentees were matched to one of their preferred mentors.
Keep and eye for the future program notifications. See you all at #Dros26
Below are the mentee demographics and response summary.
(1/n)

Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...

INTERESTED IN SINGLE-CELL LINEAGE TRACING?

Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉

nature.com/articles/s41...

With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis.

Read link: rdcu.be/e50gy

If you want a science cleanse today, read and celebrate the accomplishments of these amazing young scientists

Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucos…

"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa"

Nobody can predict what can happen with your work.

www.sciencedirect.com/science/arti...

You are the best - Thank you 🥹
See you next week ☺️

#Dros26

#Dros26

In addition to all the well-documented stresses on the system, reviewer fatigue/saturation drives worse reviews which in turn promotes more journal shopping by authors which leads to paper recirculation and, yes, you guessed it, more reviewer fatigue 😵‍💫

@reviewcommons.org @asapbio.bsky.social

Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

'Here we trace the historical roots of how Mendelian classical genetics departed from the biometric school to create the current predominant paradigm in genetics, despite fundamentally unresolved issues'

Congratulations to Judith Kimble on her Thomas Hunt Morgan Medal!

#celegans #womeninSTEM

🧬 Edward Novitski Prize: Mike O’Connor, University of Minnesota
🏅 GSA Medal: @schacherer.bsky.social, @unistra.fr
🧑‍🏫 GSA Mentorship Award: @irinakitop@bsky.social, @fredhutch.org

3/3🧵

🏫 Elizabeth W. Jones Award for Excellence in Education: Brian Donovan
🎓 GSA Early Career Medal: @mexpositoalonso.bsky.social, @ucberkeleyofficial.bsky.social
🌎 Thomas Hunt Morgan Medal: Judith Kimble, @uwbiochem.bsky.social
🔬 George W. Beadle Award: Aaron Mitchell, @universityofga.bsky.social

2/3🧵

Congrats to our 2026 GSA Award recipients! They have made significant contributions to science, including scientific discoveries, mentoring, creation of community resources, and education. Learn more about them: buff.ly/6zAwQQ1

Join us in celebrating their accomplishments.👏

1/3🧵⬇️

I use zotero all the time and it's so good. It's so far my favorite citation app.

@embl.org at its best: collaborative, open, transformative, and just the right amount of crazy. Dreaming of mechanistic cell biology *in the natural environment*? Dream no more, rent the AML.

www.biorxiv.org/content/10.6...

www.youtube.com/watch?v=jepb...

#WeFreezeOnTheBeach #ProtistsOnSky 🦠🌍🧪

a woman is sitting at a table eating a piece of cake . ALT: a woman is sitting at a table eating a piece of cake .

Experiment not experimenting
And brain not braining
Only stress eating 😭

Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London on FindAPhD.com PhD Project - Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London, listed on FindAPhD.com

Fully Funded PhD Studentship Opportunity (4 years) at Queen Mary, University of London

Why is gum disease a risk factor for dementia? Come and help us find out!

🗓 Application deadline: 15th May 2026
Apply here: tinyurl.com/4xvdzpjs

Please share! #Microbiome #Dementia #neuroskyence 🧪
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A card announcing the call for papers stating 'Special Issue: The Integrative Biology of Reproduction Guest Editors: Etya Amsalem, Tony D. Williams and Kathryn Wilsterman. Submission deadline: 30 June 2026' with the Journal of Experimental Biology logo and the logo for the Special Issue containing an egg cell surrounded by eight sperm cells. The eighth sperm, on the top right, is penetrating the egg.

We are calling for Reviews, Commentaries or research papers for our upcoming Special Issue: The Integrative Biology of Reproduction, covering the entire reproductive process, from mate selection, mating and egg-laying or pregnancy through to parental care

bit.ly/3ZT42hY