Glenn Masson

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

Wonderful to be part of this study with Stefan et al.!

Bumper year...

The mitotic stopwatch limits the proliferation of whole genome doubled cells Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...

Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.

Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek

www.biorxiv.org/content/10.1...

at another conference but was extremely keen to go to that one too...keep us posted!

It's August

How does nutrient-responsive #mTORC1 sense the key amino acid #glutamine?
Gianluca Figlia, Aurelio Teleman et al @telemanlab.bsky.social identify a combination of GCN2-dependent processes triggered by secondary depletion of asparagine in glutamine-starved cells
www.embopress.org/doi/full/10....

Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibition CDK4/6 inhibitors (CDK4/6i) arrest the cell cycle in G1 leading to cellular overgrowth and p53-dependent senescence. They are used to treat metastatic HR+/HER2-breast cancer, but resistance is common,...

Check out our latest work on cell cycle inhibitors, which has implications for how cancer cells could become resistant to these drugs
#senescence #cellcycle #cancer 🧪

www.biorxiv.org/content/10.1...

That wonderful feeling of coming home to Scotland after a week's holiday in Ireland only to realise you left your suitcase back in Ireland. Along with your washbag. And your laptop. Outside. In the rain.

Self inflicted stupidity like this is a luxury afforded by civilized society. There's still a safety net of healthcare and the forgiving tolerance of learned ignorance of affluent population - if and when those buffers fall away, it'll all come tumbling down...

We've just posted a new preprint:

"A GCN1-independent activator of the kinase GCN2"

Paradoxical Activation of GCN2 by ATP-competitive inhibitors via allosteric activation and autophosphorylation Recently it has been found that General Control Non-derepressible 2 (GCN2) can be activated by an array of small molecule ATP-competitive inhibitors, including clinically relevant compounds such as Po...

Congratulations to Graham Neill who passed his PhD Viva today! 👏🎉👏🎉First PhD from the lab! Many thanks to Tony Ly from Dundee SLS and @antoncalabrese.bsky.social from Leeds for grilling Graham on all things kinases + hdx-ms. Read about Graham's Research on GCN2 here: www.biorxiv.org/content/10.1...

.. will use the same pathway to produce that result each time? It feels at this point that there's some sort of chaos theory going on here - or it's similar to meteorology where we can be predict broad trends but we will never get to a truly get to a granular model

Went to sleep ruminating about this. At what point do we say that the eukaryotic cell is a black box? We can frequently predict the result of an input (eg adding insulin to a cell) but the emergent phenotype may be the result of wildly different processes. Can we even say that the same cell ..

PostDoc Position (m/f/d) in Structural Biology of Membrane Protein Complexes

Main focus of the job will be Cryo-EM of membrane protein comolexes as well as protein/nucleic acid complexes involved in innate immunity.

For more information, check this:

www.mpi-dortmund.mpg.de/news/jobs/po...

I'm not going to be able to drive in Wales without thinking this now, thanks for that

Very happy to present some of our research on HDX-MS at the Royal Society/ Japanese Society Promotion of Science joint meeting in London today. Incredibly interesting meeting on a very broad array of topics.

A birthday treat for me and the wee one. Caught a bucket full of trout and cod, the seas were very choppy but glad to report my son has an iron stomach (which couldn't be said for some of our fellow fishers). Son delighted and ate his own cod for supper.

Delighted to share research on ISR kinase & Parkinson's target HRI, with help from @mrcppu.bsky.social's Miratual Muqit, spearheaded by MSc student Shivani. Recently, I presented this (far too quickly) at @ukproteostasis.bsky.social- if you wanted more details, here they are! tinyurl.com/5n7ptvju

Congrats Melissa!

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor - Nature Communications Gammons et al. describe how the clustering of the Wnt receptor complex in clathrin-coated locales allows Axin and GSK3 to dock at adjacent tails of the LRP6 co-receptor to assemble a signalosome that ...

Excited to share our recent paper on the Wnt signalosome www.nature.com/articles/s41...

The swifts have returned and are ruling the skies of Leuchars once more

Cryo-EM structure of CASTOR1-GATOR2 complex

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Congratulations to Miratul and the team, wonderful project to be privy to. www.science.org/doi/10.1126/...

Telling my 5 y.o. son that the cuckoos we here are from Africa, and he just flat out doesn't believe me. "They flew here" "Maybe from London, or Edinburgh, but not Africa"

I grew up in westerham and loved visiting it...good day to visit Quebec house too!

Efficient, Zero Scrambling Fragmentation of Deuterium Labeled Peptides on the ZenoToF 7600 Electron Activated Dissociation Platform Hydrogen–deuterium exchange (HDX) mass spectrometry (MS) has become an increasingly important tool in protein research, with large-scale applications in biopharmaceutical development and manufacturing...

Ok folks, here it is: Joe Anacleto (with some help from his friends) demonstrates zero sensitivity loss, zero scrambling site specific HDX. Next up: Site specific HDX-MS profiles of drug candidates in *real-world* drug development... And after that? High throughput!

pubs.acs.org/doi/abs/10.1...

Well, I really didn't think Gcn2 bound to the ribosome there, or in that state of ribosomal stress. Like all good papers, this answers some questions but asks many too!

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