bioRxiv Biochemistry

Modulation of serotonergic, dopaminergic and tubulin-associated pathways by tannin-free natural products in Caenorhabditis elegans reveals effective anthelmintic drug targets https://www.biorxiv.org/content/10.1101/2025.10.05.679051v1

Quantitative Substrate Kinetics Screening: One-Pot LC/MS Based Approach to Map Protease Specificity https://www.biorxiv.org/content/10.1101/2025.10.06.680748v1

Mapping Structural Constraints and Adaptive Potential in a Capsule-Degrading Phage Tailspike Protein https://www.biorxiv.org/content/10.1101/2025.10.06.680778v1

Structurally Informed Fitness Landscapes for Surveillance of Emerging PRRSV Variants https://www.biorxiv.org/content/10.1101/2025.10.06.680729v1

The structure of the full catalytic cycle of Vibrio cholerae NFeoB https://www.biorxiv.org/content/10.1101/2025.10.06.680749v1

Geographical Origin and Variety Differentiation of Kava (Piper methysticum) using Artificial Neural Network with FTIR Spectroscopy: A Novel Method https://www.biorxiv.org/content/10.1101/2025.10.05.679113v1

Metal speciation in blood plasma https://www.biorxiv.org/content/10.1101/2025.10.04.680475v1

Myoglobin leaching into the serum of IDA mice is driven by the high activation of sGC under anemic conditions which induces myoglobin expression https://www.biorxiv.org/content/10.1101/2025.10.03.680120v1

RNA sequence design and protein-DNA specificity prediction with NA-MPNN https://www.biorxiv.org/content/10.1101/2025.10.03.679414v1

Glutamine-Dependent Slc25a39-Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment https://www.biorxiv.org/content/10.1101/2025.10.02.680066v1

Cryo-EM structure of the FtsH periplasmic domain reveals functional dynamics https://www.biorxiv.org/content/10.1101/2025.10.03.679995v1

Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events https://www.biorxiv.org/content/10.1101/2025.10.03.680315v1

Clinically observed RASA1 missense mutants exhibit diverse RasGAP protein behaviors https://www.biorxiv.org/content/10.1101/2025.10.03.680326v1

Biochemical assessment of α-α-subunit interactions of Nav1.5 in a heterologous expression system https://www.biorxiv.org/content/10.1101/2025.10.02.679760v1

Quantitative Prevalence, Chemical Speciation, and ECM-Embedded Networks of Biogenic Silicon in Animal Tissues Revealed by Refined Analytical Methods https://www.biorxiv.org/content/10.1101/2025.10.02.679922v1

A Covalent PFKL Activator Suppresses Tumor Growth https://www.biorxiv.org/content/10.1101/2025.10.02.680014v1

Cathepsin K as a Key SARS-CoV-2 Cell Entry Protease and Dual-Inhibition Target https://www.biorxiv.org/content/10.1101/2025.10.03.680348v1

Spatially Organized DNA-templated Silver Nanoclusters as Potent Antimicrobial Agents for ESKAPE Infections https://www.biorxiv.org/content/10.1101/2025.10.02.680010v1

The importance of UBQLN2 ubiquitylation for its turnover and localization https://www.biorxiv.org/content/10.1101/2025.10.02.679934v1

Coordination of Anle138b to Silver Results in Selective Reduction of a C-terminal truncated Alpha-synuclein Protein and Increased Aggregate Size https://www.biorxiv.org/content/10.1101/2025.10.01.679869v1

Ethanol consumption mediates parasitoid resistance via effects on host metabolism https://www.biorxiv.org/content/10.1101/2025.10.01.679850v1

DnaJB1 chaperone inhibits tau aggregation by recognizing its N-terminus https://www.biorxiv.org/content/10.1101/2025.10.02.680111v1

Ribosomal frameshifting is a carefully tuned modifier of proteins https://www.biorxiv.org/content/10.1101/2025.10.02.679949v1

De novo design of RNA and nucleoprotein complexes https://www.biorxiv.org/content/10.1101/2025.10.01.679929v1

CXCR1 and CXCR2 display receptor bias for shared chemokine agonists https://www.biorxiv.org/content/10.1101/2025.09.30.679682v1

Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7 https://www.biorxiv.org/content/10.1101/2025.10.01.679551v1

Assembly and substrate engagement mechanism of the bacterial proteasome activator Boa https://www.biorxiv.org/content/10.1101/2025.10.01.679806v1

Improved T cell surfaceomics by depleting intracellularly labelled dead cells https://www.biorxiv.org/content/10.1101/2025.09.30.679609v1

The Drosophila PDGF/VEGF signaling pathway regulates host immunometabolism in response to parasitoid infection https://www.biorxiv.org/content/10.1101/2025.10.01.679819v1

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase https://www.biorxiv.org/content/10.1101/2025.09.30.679521v1