Dr Jacinta Kalisch-Smith

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)

Exciting news! Dr Jacinta Kalisch-Smith, @jkalism.bsky.social, has been awarded a BHF fellowship to explore how placental blood vessels support fetal growth and development.

Her research could change how we detect and prevent complications during pregnancy.

🔗 Read more: shorturl.at/OVzqq

Figure 3: Human villous feto–placental blood vessel development.

Feto-placental blood vessel development

In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field:
doi.org/10.1242/dev....

Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!

@evborg.bsky.social @anzpra1.bsky.social

This Review discusses placental vascular progenitors and derivatives (with their molecular markers), genetic knockouts, trophoblast-endothelial signalling, co-occurrence with embryonic heart defects, genetic tools and pathologies that are impacted by placental vascular defects.

I hope it will be a good reference for the community and will help inspire other vascular and placental biologists to investigate the placental vasculature.

@socdevbio.bsky.social @bsdb.bsky.social @navbo.bsky.social @oxforddpag.bsky.social @ox.ac.uk @biologists.bsky.social

Feto-placental blood vessel development Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.

Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.

journals.biologists.com/dev/article/...

@idrm.ox.ac.uk Funded by the @thebhf.bsky.social

Moment of heart’s formation captured in images for first time Time-lapse footage reveals cardiac cells in a mouse embryo begin to organise themselves during early development

Nice highlight on this recent @embojournal.org paper!
www.theguardian.com/science/2025...

I had a some great news this week, being awarded an independent @thebhf.bsky.social fellowship. Thanks to the support from @idrm.ox.ac.uk @oxforddpag.bsky.social @ox.ac.uk colleagues past and present. Looking forward to the next few years investigating placental vascular development.

Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...

✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨

A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract

tinyurl.com/LECspec

Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.

Limit on human embryo research should be extended to 28 days, says UK regulator Experts say increasing law from 14 days could lead to breakthroughs in understand of miscarriages

Here in the UK, the HFEA is recommending changing the 14-day rule on human embryo research to allow culture up to 28 days. This will open up new avenues of research into previously inaccessible stages of development, and potentially provide new understanding of the causes of early pregnancy failure.

After 3,000 years of science, the embryo is very different | Aeon Essays For 3,000 years, humans have struggled to understand the embryo. Now there is a revolution underway

Side-hustle activated. Stoked to have this popular science piece out in Aeon Magazine:

aeon.co/essays/after...

@oxforddpag.bsky.social
@idrmoxford.bsky.social

Sorry to hear this Tom, hope someone can help you get some feedback. I certainly wouldn't have progressed without it.

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

Nice to see our latest review published in
@natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social

www.nature.com/articles/s41...