Theresa Ramalho

What Rosalind Franklin truly contributed to the discovery of DNA’s structure Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science

www.nature.com/articles/d41...

James Watson, dead at 97, was a scientific legend and a pariah among his peers James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.

"he didn’t know when to get off the stage". So many Watsons around current science still 🤯 www.statnews.com/2025/11/07/j...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease www.nature.com/articles/s41...

Physical activity and risk of Alzheimer's disease.
In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition
@naturemedicine.bsky.social
nature.com/articles/s41...

Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of...

📣 NEW STUDY 📣 @cp-immunity.bsky.social by Maria Lafaille's lab shows how long-lived IgE-producing plasma cells survive & sustain allergy without continued allergen exposure: maturing in spleen & bone marrow with a unique survival program that resists cell-death signals 🧐 www.cell.com/immunity/abs...

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://

www.sciencedirect.com/science/article/abs/pii/S1097276525008196

Congratulations @bensahralab.bsky.social !!

Migo, traduz, porfafor 🙏

🙏

Preprint: nucleolar stress-induced accumulation of cytosolic ribo-RNA-DNA hybrids that prime innate immunity
www.researchsquare.com/article/rs-7...

Biological Laboratory | LEGO® Ideas This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...

Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied stra...

Read the latest #SMIMemberPaper by Stephanie Eisenbarth and colleagues in Science Magazine on how leukotrienes in the intestine control Food Allergy responses. Read more: www.science.org/doi/10.1126/...

Minha amiga Thiaga

What happens if pregnant women stop taking Tylenol? Nature - Untreated fevers during pregnancy can cause more harm than taking paracetamol will, scientists say.

Avoiding Tylenol when needed could place women and their fetus at great risk

go.nature.com/3Ikpjfz

Equity in science is a beautiful lie — and I’m done pretending Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system.

Agreed www.nature.com/articles/d41...

Sim

O Agente Secreto é o filme escolhido para representar o Brasil na categoria Melhor Filme Internacional no Oscar 2026! Em busca do Bi!

ICYMI: New content online: A call for a multidisciplinary intervention to address severe insulin resistance during pregnancy

This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

ICYMI: New online! Dementia research in low-income and middle-income countries — a view from Latin America

Great initiative!

Is Social Media More Like Cigarettes or Junk Food? Lawmakers attempting to regulate children’s access to social media must decide whether bans or warning labels are the optimal route for keeping kids safe.

In recent years, experts have been warning that social media harms children. Should it be banned for younger users, like cigarettes, or regulated, like junk food?

Immigrant–native pay gap driven by lack of access to high-paying jobs - Nature Data from nine European and North American countries reveal that the disparity in earnings between immigrants and natives is largely a result of segregation of immigrant workers into lower-paying jobs.

Nature research paper: Immigrant–native pay gap driven by lack of access to high-paying jobs

go.nature.com/40ripuF

It looks like a joint in his mouth 🐰

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable a unique form of ubiquitination-independent proteolysis. This study also unveils midnolin downregulation as a key driver of multiple myeloma through the aberrant stabilization of IRF4.

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Why women experience Alzheimer’s disease differently from men Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.

Two out of every three people with Alzheimer’s are women, and the greatest risk factor after old age is being a woman. A Nature Outlook article shows how a decade of research studying the effects of sex and gender on the disease is starting to bear fruit. #medsky #alzsky 🧪

Warming of +1.5 °C is too high for polar ice sheets - Communications Earth & Environment Warming of +1.5 °C above pre-industrial levels is too high for the Greenland and Antarctic ice sheets, and even the current climate forcing of +1.2 °C is likely to lead to several meters of sea-level rise, meaning that only a return to +1 °C or lower will avoid extensive loss and damage to coastal populations, according to a synthesis of recent evidence.

Warming of +1.5 °C above pre-industrial levels is too high for the Greenland and Antarctic ice sheets, and even the current climate forcing of +1.2 °C is likely to lead to several meters of sea-level rise, according to a study in Communications Earth & Environment. 🧪

nesta casa defendemos e aclamamos kleber mendonça filho

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on codon optimality and conserved across species, establishes direct feedback coupling the translation of new proteins with the stability of the mRNA that encodes for them.

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay

Personalized Gene Editing to Treat an Inborn Error of Metabolism www.nejm.org/doi/full/10....
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease @ahrensnicklas.bsky.social @kiranmusunuru.bsky.social
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....