That's just one way lenacapavir can stop the virus. It's so effective as a therapeutic & prophylactic because it targets multiple stages of the HIV life cycle. Others have shown that it also stops the capsid from entering the nucleus, & disrupts assembly of new capsids.
13.12.2024 11:17 — 👍 0 🔁 0 💬 0 📌 0
Super cool to see @science.org named anti-HIV drug lenacapavir as Breakthrough of the Year. 🧪This breakthrough is underpinned by a wealth of basic research. Our contribution is to show how the drug cracks the protective HIV capsid 👇https://doi.org/10.7554/elife.83605
13.12.2024 11:17 — 👍 9 🔁 4 💬 2 📌 0
Thanks for pointing this out. New link: www.nature.com/articles/s41...
26.11.2024 05:02 — 👍 1 🔁 0 💬 1 📌 0
Hi Johannes, could you please add us?
18.11.2024 09:07 — 👍 1 🔁 0 💬 1 📌 0
Artistic depiction of the HIV capsid disguised as a host chaperone protein
The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature.
@singmolsci.bsky.social #UNSWSBMS
🔗 nature.com/articles/s41...
🎨: Jon Berengut
25.01.2024 00:27 — 👍 14 🔁 6 💬 1 📌 0
We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023
🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52...
28.11.2023 05:55 — 👍 6 🔁 4 💬 0 📌 0
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
🚨preprint @biorxivpreprint.bsky.social
We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...
28.11.2023 05:50 — 👍 1 🔁 1 💬 0 📌 0
Ariel photo of UNSW's main campus located near close to beaches
🚨Join us at UNSW Sydney!
We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠.
#SingleMolecule #microscopy🔬
Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics
08.11.2023 06:11 — 👍 6 🔁 2 💬 0 📌 2
Investigating viruses, using pipettes, #AI and coffee.
Learn more at the lab website: https://grovelab.github.io/
Check out our database of viral protein structure predictions: https://viro3d.cvr.gla.ac.uk/
Based at: @cvrinfo.bsky.social
Structural virology group leader at Umeå University, Sweden.
Emeritus Professor at Fred Hutch in Seattle. My lab studied HIV and other viruses. My main account is on Mastodon: @memerman@mstdn.science where I post about virology, hiking, biking and gardening. Here, mostly to follow virologists and other friends.
The Nynke Dekker Lab at the University of Oxford
https://nynkedekkerlab.web.ox.ac.uk
single-molecule biophysics, biochemistry, DNA replication, chromatin, fluorescence, tweezers, and more!
Virologist | Professor of Sneezy Diseases | studies influenza @ MRC-University of Glasgow Centre for Virus Research | occasionally draws things | (he/him)
https://www.gla.ac.uk/schools/infectionimmunity/staff/edwardhutchinson/
forever virologist, researcher, PCR guy. past lab manager. husband. dad. reader. writer. fixer. bad typist. learner. australian.
#MasksWork
https://virologydownunder.com/
professor at UCSF, engineer turned cell biologist, wants to know how cells solve geometry problems
Official Account for the Lorne Protein Meeting, Australia.
lorneproteins.org
Molecular cell biology, electron microscopy. Endocytosis, caveolae, lipid droplets, nanoparticles. Cultured cells, zebrafish, tardigrades.
Biophysicist and big fan of fluorescent microscopy, microfluidics, and pore forming proteins 🔬Postdoc Boecking group UNSW, previously Postdoc candidate Van Oijen/Spenkelink group UOW
Synthetic organic chemistry at the University of Groningen and the Stratingh Institute for Chemistry | #ChemNobel 2016 | Making smart molecules & forging stereocenters since '88
https://benferinga.com
ARC Future Fellow leading the Viruses and Innate Immunity Lab in Meanjin/Brisbane, Australia. Interested in all things influenza, innate immunity and inflammation. Macrophages are our favourites but we love endothelial cells and epithelial cells too.
All views and opinions expressed are my own.
Senior Research Fellow @UOW | single molecules | DNA replication | protein evolution | views are my own | she/her
https://scholars.uow.edu.au/lisanne-spenkelink
Professor of single protein and single cell biophysics . Utilizing machine learning for quantitative analysis of live cell imaging and single particle tracking
https://www.hatzakislab.com
orcid.org/0000-0003-4202-0328
Building microscopes at #umich to measure chemistry, physics, and biology one #singlemolecule at a time (she/her)
https://sites.lsa.umich.edu/biteen-lab/
Group Leader and Lecturer at the Australian National University | researching bacterial thiol redox pathways and virulence factors | community builder | storyteller | views my own | she/her
The Global Academy is a network of researchers around the world who are working to help us meet the UN Sustainable Development Goals by 2030.
#SDGs #Postdoc #PhDchat #ResearchForTheGoals
Structural biologist studying proteins that move things from A to B. University of Queensland, Institute for Molecular Bioscience. Centre for Cell Biology of Chronic Disease.
He/Him.
https://imb.uq.edu.au/research-groups/collins
