Ioana Genescu

Happy to see this out, go check it 🤩 !!!Congrats to all 🎉

📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑‍🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!

Vision Restored Using Prosthetic Retinal Implant The device could help a million people with a severe form of macular degeneration to be able to see enough to read.

For the first time, researchers have restored some vision to people with a common eye disease by using a prosthetic retinal implant. The treatment could improve the lives of an estimated one million people in the U.S. who lose their vision to the condition if it's approved for broader use.

We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.

tinyurl.com/2jxezabw

Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro

#multiomics
#singlecell
#physiology

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇

Early lineage divergence segregates sensory and non-sensory thalamic circuits The thalamus integrates sensory, motor, and associative functions via distinct nuclei, yet the developmental principles driving their specification remain unclear. Here, we generate a spatiotemporal s...

Excited to share our new preprint on #thalamus development! 🧠 We reveal how sensory and non-sensory circuits are specified in embryogenesis #mutiomics, #spatialtranscriptomics, #lineagetracing. @neuroalc.bsky.social @glb-lab.bsky.social @jplopez-atalaya.bsky.social www.biorxiv.org/content/10.1...

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵

www.biorxiv.org/content/10.1...

Amazing comic @brainotopia.bsky.social !!🤩

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

🚨 New Paper Alert! 🚨

I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.

Link below 👇
www.cell.com/cell/fulltex...

@cellpress.bsky.social @marinlab.bsky.social

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

ATLAS: a rationally designed anterograde transsynaptic tracer - Nature Methods ATLAS is a tool for circuit tracing, demonstrated here in rodents. It allows anterograde transsynaptic tracing, starting from genetically defined neurons.

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on
@addgene.bsky.social
addgene nature.com/articles/s41...

Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...

New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

The beginning of a beautiful collaboration 🤩 curious about what the result will be !

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!

Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏

Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!

Scenes from the incredible turnout today at Berkeley's @standupforscience.bsky.social rally. @tedmiguel.bsky.social, @jenniferdoudna.bsky.social, and dozens of researchers, elected officials, and citizens defended science and the jobs, health benefits, and progress it creates for all Americans.

Super proud of this massive work led by Mar Anibal from the lab. Early rescaling of barrel maps is possible and thanks to a transcriptional switch in thalamic neurons! Check it out!
@neuroalc.bsky.social

Dynamic regulation of cortical interneuron wiring Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…

Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...

NEW: updated long-run gap in voting between young men and women in Germany:

Gender divide continues to widen, but contrary to what is often assumed, young men continue to vote roughly in line with the overall population, while young women have swung sharply left.

www.ft.com/content/29fd...