bioRxiv Immunology

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis https://www.biorxiv.org/content/10.1101/2025.10.06.680736v1

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions https://www.biorxiv.org/content/10.1101/2025.10.02.680083v1

Molecular signature of neutrophils in antiphospholipid syndrome based on epigenomic and transcriptome analysis https://www.biorxiv.org/content/10.1101/2025.10.03.680196v1

Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains https://www.biorxiv.org/content/10.1101/2025.10.03.679858v1

Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1

Pre-division TCF1 drop determines long-term CD8 T cell fates https://www.biorxiv.org/content/10.1101/2025.10.06.680655v1

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design https://www.biorxiv.org/content/10.1101/2025.10.06.680687v1

Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation. https://www.biorxiv.org/content/10.1101/2025.10.06.680668v1

Site-specific genome engineering of primary human natural killer cells for programmable anti-tumor function https://www.biorxiv.org/content/10.1101/2025.10.05.680386v1

UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome https://www.biorxiv.org/content/10.1101/2025.10.06.680650v1

Adenovirus-based vaccines transduce and activate human Langerhans cells https://www.biorxiv.org/content/10.1101/2025.10.06.680090v1

A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice https://www.biorxiv.org/content/10.1101/2025.10.06.680344v1

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy https://www.biorxiv.org/content/10.1101/2025.10.05.680562v1

Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection https://www.biorxiv.org/content/10.1101/2025.10.03.680384v1

Immunomodulatory Effects of a Cell Processing Device: Insights from Single Cell RNA Sequencing and Gene Set Enrichment Analysis https://www.biorxiv.org/content/10.1101/2025.10.03.680363v1

Complement activation in maternal and placental pathology of preeclampsia https://www.biorxiv.org/content/10.1101/2025.10.03.680407v1

Progenitor T cells drive chronic pulmonary type 2 inflammation https://www.biorxiv.org/content/10.1101/2025.10.03.680133v1

Targeting a macrophage stemness factor to mitigate diseases post respiratory viral infection https://www.biorxiv.org/content/10.1101/2025.10.03.680366v1

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1

Methionine regulates antitumor function of CD8⁺ T cells through polyamine synthesis https://www.biorxiv.org/content/10.1101/2025.10.03.680201v1

Dynamics of memory B cells and plasmablasts in healthy individuals https://www.biorxiv.org/content/10.1101/2025.10.03.680203v1

Human immune response to primary cryptosporidiosis parallels murine infection models https://www.biorxiv.org/content/10.1101/2025.10.03.680261v1

Mucosal vaccine immunity induced by a new auxotrophic Pseudomonas aeruginosa strain is linked to Th17 and IgA responses https://www.biorxiv.org/content/10.1101/2025.10.03.679932v1

Mechanisms of Differential Signal Transduction by IFNLR1 Variants https://www.biorxiv.org/content/10.1101/2025.10.03.677101v1

ETV4 restrains the formation of CD74+ cytotoxic exhausted CD8+ T cells https://www.biorxiv.org/content/10.1101/2025.10.02.677509v1

Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages https://www.biorxiv.org/content/10.1101/2025.10.02.679826v1

Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing Myogenesis https://www.biorxiv.org/content/10.1101/2025.10.02.679938v1

Immune Cell Dysfunction of SARS-CoV-2: Mathematical Modeling of the Within-Host Immune Dynamics https://www.biorxiv.org/content/10.1101/2025.10.03.680253v1

Discovery of rare antigen-specific TCRs via replicate profiling https://www.biorxiv.org/content/10.1101/2025.09.30.675572v1

Synthetic signaling platform uncovers and rewires cellular responses to PD-1 perturbation https://www.biorxiv.org/content/10.1101/2025.10.01.679874v1